Results 71 to 80 of about 16,392 (208)

Expression of TLR5 in Different Types of Non-small Cell Lung Cancer Cell Lines and its Activation Mechanism

Chinese Journal of Lung Cancer, 2015
Background and objective It has been proven that toll-like receptor 5 (TLR5) plaied an important role in the development of tumor. In our previous study, we found that the expression of TLR5 was remarkably higher in non-small cell lung cancer (NSCLC ...
Hui ZHOU, Mei LUO, Yige WEN, Andi MA, Yongzhong LUO, Qing YI, Jianhua CHEN, Ling XIAO   +7 more
doaj   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

Role of Toll-Like Receptor 5 (TLR5) in Experimental Melioidosis

, 2019
The Gram-negative intracellular pathogen Burkholderia pseudomallei is the causative agent of melioidosis, an important cause of sepsis in Southeast Asia. Recognition of pathogen-associated molecular patterns by Toll-like receptors (TLRs) is essential for
Birnie, Emma, de Vos, Alex F., Lankelma, Jacqueline M., Koh, Gavin C. K. W., van Lieshout, Miriam H. P., Roelofs, Joris J. T. H., Weehuizen, Tassili A. F., Wiersinga, W. Joost, van der Poll, Tom, Budding, Andries E., de Jong, Hanna K.   +10 more
core   +1 more source

Analysis of substitution rates showed that TLR5 is evolving at different rates among mammalian groups

BMC Evolutionary Biology, 2019
Background Toll-like receptors (TLRs) are the most widely studied innate immunity receptors responsible for recognition of invading pathogens. Among the TLR family, TLR5 is the only that senses and recognizes flagellin, the major protein of bacterial ...
Ana Pinheiro, Ana Águeda-Pinto, José Melo-Ferreira, Fabiana Neves, Joana Abrantes, Pedro J. Esteves   +5 more
doaj   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Expression of TLR5 by cultured cardiomyocytes and whole heart tissue.

, 2013
A, RT-PCR analysis of tlr5 transcription on H9c2 total RNA. C-, negative control (no RNA); C+, positive control. Sizes of the amplified fragments: 310 bp (C+); 381 bp (TLR)5. B, TLR5 protein expression in H9c2 cells.
Jianhui Li (361790), Lucas Liaudet (361794), Pal Pacher (85730), François Feihl (361792), Bernard Waeber (79715), Joelle Rolli (361788), Nathalie Rosenblatt-Velin (361789), Sandra Levrand (361791), Noureddine Loukili (246582), Patrick Ruchat (361793)   +9 more
core   +1 more source

To Move or Not to Move: When and How Bacteria Suppress Flagellar Motility

Molecular Microbiology, EarlyView.
Motility cessation in bacteria is a key regulatory strategy that provides multiple survival advantages including enhanced community cooperation, niche adaptation and evasion of host immune responses. This process is controlled by associated mechanisms such as post‐translational modifications and second messenger signalling that stabilise non‐motile ...
Fatemeh Mohagegh, Jacob Scadden, Matthew A. B. Baker   +2 more
wiley   +1 more source

A conserved TLR5 binding and activation hot spot on flagellin [PDF]

Scientific Reports, 2017
AbstractFlagellin is a bacterial protein that polymerizes into the flagellar filament and is essential for bacterial motility. When flagellated bacteria invade the host, flagellin is recognized by Toll-like receptor 5 (TLR5) as a pathogen invasion signal and eventually evokes the innate immune response. Here, we provide a conserved structural mechanism
Song, Wan Seok, Jeon, Ye Ji, Namgung, Byeol, Hong, Minsun, Yoon, Sung-il   +4 more
openaire   +3 more sources

Upregulation of TLR5 indicates a favorable prognosis in prostate cancer

The Prostate, 2023
AbstractBackgroundToll‐like receptors (TLRs) are the key sensors of innate immunity for triggering immune responses against infections. TLRs are well known to be expressed and activated in innate immune cells, such as macrophage and dendritic cells, but we and others have found that some TLRs are also functional in epithelial cells.
Hongbin Liang, Lin Zhang, Ziying Liu, Bettina Hoden, David DeRubeis, Yifan Zhang, Fen Wang, Dekai Zhang   +7 more
openaire   +2 more sources