Results 71 to 80 of about 670 (133)

Molecular Characterization and Evolution Analysis of Two Forms of TLR5 and TLR13 Genes Base on Larimichthys crocea Genome Data

International Journal of Genomics, 2020
TLRs (Toll-like receptors) are essential in host defense against pathogens. There are two types of TLR5, namely, membrane form of TLR5 (TLR5M) and soluble form of TLR5 (TLR5S), both of which perform a crucial role in flagellin response.
Lihua Jiang, Liyi Pei, Ping Wang, Liqin Liu, Gong Li, Binjian Liu, Zhenming Lǚ, Tabata Hiromasa, Hao Pan, Atsushi Ogura   +9 more
doaj   +1 more source

Evolutionary Response Patterns of the Rodent TLR Genes to Climatic Factors

Ecology and Evolution, Volume 16, Issue 9, September 2026.
This study systematically investigates the associations between climatic factors and the evolutionary dynamics of Toll‐like receptor (TLR) genes across 42 rodent species. Our findings demonstrate that temperature‐related climatic variables (Annual Mean Temperature, Mean Diurnal Range, and Max Temperature of Warmest Month) may modulate the evolutionary ...
Chao Zhao, Tian Xia, Guangshuai Liu, Zhao Liu, Xinglei Ding, Shuo Dai, Honghai Zhang   +6 more
wiley   +1 more source

Bile acid metabolism and signaling in human and animal health: A One Health perspective

iMetaOmics, Volume 3, Issue 3, September 2026.
Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li, Shuai Liu, Zhijun Cao, Yangchun Cao, Shengru Wu, Lu Deng, Junhu Yao, Jun Zhang   +7 more
wiley   +1 more source

Effect of Weight-Reduction in Obese Mice Lacking Toll-Like Receptor 5 and C57BL/6 Mice Fed a Low-Fat Diet

Mediators of Inflammation, 2015
Background. This study aims to investigate the effect of feeding low-fat diet (LFD) to diet-induced obesity (DIO) mice lacking TLR5 (TLR5−/−), which have a tendency to develop glucose intolerance with increased adiposity, compared to that in C57BL/6 mice.
Shao-Chun Wu, Cheng-Shyuan Rau, Tsu-Hsiang Lu, Siou-Ling Tzeng, Yi-Chan Wu, Chia-Jung Wu, Chia-Wei Lin, Ching-Hua Hsieh   +7 more
doaj   +1 more source

Microbiome—pancreatic cancer crosstalk: From tumor biology to therapeutic intervention

iMetaOmics, Volume 3, Issue 3, September 2026.
The intratumoral microbiome acts as a critical regulator in pancreatic cancer progression and therapeutic resistance. This comprehensive review delineates the origins of pancreatic microbes, elucidates their multifaceted mechanisms in driving immune suppression, metabolic reprogramming, and stromal desmoplasia, and highlights the clinical potential of ...
Yuqin Xie, Jingyuan Ye, Sheng Wang, Maoyun Liu, Fengsheng Dai, Mingzhen Bai, Yi Wang, Athena Savoji, Yu Wang, Phillip B. Hylemon, Huiping Zhou, Hui Li, Dewei Li   +12 more
wiley   +1 more source

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source

Pseudomonas evades immune recognition of flagellin in both mammals and plants.

PLoS Pathogens, 2011
The building blocks of bacterial flagella, flagellin monomers, are potent stimulators of host innate immune systems. Recognition of flagellin monomers occurs by flagellin-specific pattern-recognition receptors, such as Toll-like receptor 5 (TLR5) in ...
Bart W Bardoel, Sjoerd van der Ent, Michiel J C Pel, Jan Tommassen, Corné M J Pieterse, Kok P M van Kessel, Jos A G van Strijp   +6 more
doaj   +1 more source

Metabolic Syndrome: From Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 9, September 2026.
A comprehensive overview of molecular mechanisms delves into the potential disease mechanisms of metabolic syndrome, including complex mechanisms such as insulin resistance, chronic low‐grade inflammation, oxidative stress, and epigenetic modifications, and how these mechanisms contribute to the development of metabolic syndrome. Here, the relationship
Mengyao Yan, Qian Xiang
wiley   +1 more source

Microbial Signals in Cancer: Dissecting Host–Microbiota–Tumor Interactions and Potential Therapeutic Strategy

MedComm, Volume 7, Issue 9, September 2026.
Microbial signals from gut and tumor‐resident bacteria, fungi, viruses, and bacteriophages reshape immune and metabolic networks within the tumor microenvironment, thereby influencing cancer progression, treatment response. Therapeutic modulations, including dietary interventions, probiotics, antibiotics, fecal microbiota transplantation, engineered ...
Juan Lu, Mengjuan Xuan, Liang Yu, Zhongyang Xie, Qingfei Chu, Shihui Wei, Tuokai Wang, Chen Xue, Lanjuan Li   +8 more
wiley   +1 more source

Research Progress on Alleviating Inflammatory Responses by Regulating Macrophage Polarization Using Medicinal and Edible Homologous Traditional Chinese Medicines

Phytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.
This review summarizes that medicinal and edible homologous TCMs—such as Mongolian milkvetch root, common turmeric rhizome, and Angelica—alleviate chronic inflammatory diseases (IBD, RA, and AS) by inhibiting M1 and promoting M2 macrophage polarization, providing a theoretical basis for inflammation therapy and daily dietary intervention.
Cheng Zhang, Xinyi Liu, Wenlin Chen, Weilin Song, Junjie Cai, Cheng Liang, Jun Shen, Ruoxuan Liu, Yiming Xu, Chunhui Li, Chenghong Li, Yuyuan Wu, Xinyi Li, Chuwen Li, Hongxun Tao, Yuanye Dang   +15 more
wiley   +1 more source