Results 61 to 70 of about 14,414 (179)

Adaptive evolution of Toll-like receptor 5 in domesticated mammals

BMC Evolutionary Biology, 2012
Background Previous studies have proposed that mammalian toll like receptors (TLRs) have evolved under diversifying selection due to their role in pathogen detection.
Smith Sarah A, Jann Oliver C, Haig David, Russell George C, Werling Dirk, Glass Elizabeth J, Emes Richard D   +6 more
doaj   +1 more source

Recombinant TLR5 agonist CBLB502 promotes NK cell-mediated anti-CMV immunity in mice. [PDF]

PLoS ONE, 2014
Prior work using allogeneic bone marrow transplantation (allo-BMT) models showed that peritransplant administration of flagellin, a toll-like receptor 5 (TLR5) agonist protected murine allo-BMT recipients from CMV infection while limiting graft-vs-host ...
Mohammad S Hossain, Sampath Ramachandiran, Andrew T Gewirtz, Edmund K Waller   +3 more
doaj   +1 more source

MyD88‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions

Immunology, EarlyView.
MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Seshu Vardhan Pothabathula, Saurabh Mishra, Pugazhendhi Kannan, Annette Bellar, Amy Attaway, Nicole Welch, Srinivasan Dasarathy   +6 more
wiley   +1 more source

A conserved TLR5 binding and activation hot spot on flagellin [PDF]

Scientific Reports, 2017
AbstractFlagellin is a bacterial protein that polymerizes into the flagellar filament and is essential for bacterial motility. When flagellated bacteria invade the host, flagellin is recognized by Toll-like receptor 5 (TLR5) as a pathogen invasion signal and eventually evokes the innate immune response. Here, we provide a conserved structural mechanism
Song, Wan Seok, Jeon, Ye Ji, Namgung, Byeol, Hong, Minsun, Yoon, Sung-il   +4 more
openaire   +3 more sources

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Signaling through TLR5 mitigates lethal radiation damage by neutrophil-dependent release of MMP-9

Cell Death Discovery, 2021
Acute radiation syndrome (ARS) is a major cause of lethality following radiation disasters. A TLR5 agonist, entolimod, is among the most powerful experimental radiation countermeasures and shows efficacy in rodents and non-human primates as a ...
Craig M. Brackett, Kellee F. Greene, Alyssa R. Aldrich, Nicholas H. Trageser, Srabani Pal, Ivan Molodtsov, Bojidar M. Kandar, Lyudmila G. Burdelya, Scott I. Abrams, Andrei V. Gudkov   +9 more
doaj   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

A TLR5 Agonist Inhibits Acute Renal Ischemic Failure [PDF]

The Journal of Immunology, 2011
Abstract Reperfusion of ischemic organs induces a potent inflammatory response initiated by the generation of reactive oxygen species that directly damage tissue and promote leukocyte infiltration and activation that also mediate tissue injury.
Nobuyuki, Fukuzawa, Marianne, Petro, William M, Baldwin, Andrei V, Gudkov, Robert L, Fairchild   +4 more
openaire   +2 more sources

HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia

Cell Reports, 2016
Infectious and sterile inflammatory diseases are correlated with increased levels of high mobility group box 1 (HMGB1) in tissues and serum. Extracellular HMGB1 is known to activate Toll-like receptors (TLRs) 2 and 4 and RAGE (receptor for advanced ...
Nabanita Das, Varun Dewan, Peter M. Grace, Robin J. Gunn, Ryo Tamura, Netanel Tzarum, Linda R. Watkins, Ian A. Wilson, Hang Yin   +8 more
doaj   +1 more source

Molecular Characterization and Evolution Analysis of Two Forms of TLR5 and TLR13 Genes Base on Larimichthys crocea Genome Data

International Journal of Genomics, 2020
TLRs (Toll-like receptors) are essential in host defense against pathogens. There are two types of TLR5, namely, membrane form of TLR5 (TLR5M) and soluble form of TLR5 (TLR5S), both of which perform a crucial role in flagellin response.
Lihua Jiang, Liyi Pei, Ping Wang, Liqin Liu, Gong Li, Binjian Liu, Zhenming Lǚ, Tabata Hiromasa, Hao Pan, Atsushi Ogura   +9 more
doaj   +1 more source