Results 81 to 90 of about 16,392 (208)
, 2008 Cystic fibrosis (CF) lung disease is characterized by infection with Pseudomonas aeruginosa and a sustained accumulation of neutrophils. In this study, we analyzed 1) the expression of MyD88-dependent TLRs on circulating and airway neutrophils in P ...
Kappler, Matthias +10 more
core +1 more source
, 2023 Objective: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in both men and women. Toll-like receptor 5 (TLR5), an autoimmune signaling receptor that plays a role in cancer, can be exploited for the suppression of human colon ...
Biswas, Sourav +4 more
core +1 more source
Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases
Obesity Reviews, EarlyView.ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar +4 more
wiley +1 more source
A non-synonymous coding variant (L616F) in the TLR5 gene is potentially associated with Crohn's disease and influences responses to bacterial flagellin. [PDF]
PLoS ONE, 2013 Although numerous studies have implicated TLR5, or its ligands, bacterial flagellins, in the pathogenesis of Crohn's disease (CD), genome-wide association studies (GWAS) have not reported associations with the TLR5 gene.
Jared Sheridan +7 more
doaj +1 more source
Histiocytes: Multifaceted Regulators of Health and Disease
Veterinary Clinical Pathology, EarlyView.ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley +1 more source
A TLR5 Agonist Inhibits Acute Renal Ischemic Failure [PDF]
The Journal of Immunology, 2011 Abstract Reperfusion of ischemic organs induces a potent inflammatory response initiated by the generation of reactive oxygen species that directly damage tissue and promote leukocyte infiltration and activation that also mediate tissue injury.
Nobuyuki, Fukuzawa +4 more
openaire +2 more sources
Structural correlates of the amino acid residue 615 on TLR5.
, 2013 Protein homology modeling of TLR5 suggests a possible contribution of the 616L/F residue to dimerization. (a) Representation of the 3D structure of TLR5 extracellular domain (ECD) model; (b) Surface of the residues around F616; (c) Superimposition of the
David R. Mack (234842) +7 more
core +1 more source
Role of Gram‐Negative Bacterial Infections in Acute‐On‐Chronic Liver Failure
Liver International, Volume 46, Issue 7, July 2026.ABSTRACT Acute‐on‐chronic liver failure (ACLF) is a systemic disease characterised by an acute clinical deterioration of pre‐existing liver cirrhosis leading to multiple organ failure due to systemic inflammation. It may be triggered by the translocation of bacteria and bacterial compounds across the gut barrier.
Camilla Cadoli +5 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 11, 15 June 2026.Legionella pneumophila infection leads to the release of pathogen‐associated molecular patterns, which recruits the adaptor protein MYD88, initiating both activating (e.g., NF‐κB) and inhibitory (e.g., PI3K/AKT) signaling pathways that regulate IL‐12 gene expression.
Kara Vasilew +12 more
wiley +1 more source
Adaptive evolution of Toll-like receptor 5 in domesticated mammals
BMC Evolutionary Biology, 2012 Background Previous studies have proposed that mammalian toll like receptors (TLRs) have evolved under diversifying selection due to their role in pathogen detection.
Smith Sarah A +6 more
doaj +1 more source