Results 101 to 110 of about 16,392 (208)

Molecular Characterization and Evolution Analysis of Two Forms of TLR5 and TLR13 Genes Base on Larimichthys crocea Genome Data

International Journal of Genomics, 2020
TLRs (Toll-like receptors) are essential in host defense against pathogens. There are two types of TLR5, namely, membrane form of TLR5 (TLR5M) and soluble form of TLR5 (TLR5S), both of which perform a crucial role in flagellin response.
Lihua Jiang, Liyi Pei, Ping Wang, Liqin Liu, Gong Li, Binjian Liu, Zhenming Lǚ, Tabata Hiromasa, Hao Pan, Atsushi Ogura   +9 more
doaj   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, Volume 13, Issue 29, 22 May 2026.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Effect of Weight-Reduction in Obese Mice Lacking Toll-Like Receptor 5 and C57BL/6 Mice Fed a Low-Fat Diet

Mediators of Inflammation, 2015
Background. This study aims to investigate the effect of feeding low-fat diet (LFD) to diet-induced obesity (DIO) mice lacking TLR5 (TLR5−/−), which have a tendency to develop glucose intolerance with increased adiposity, compared to that in C57BL/6 mice.
Shao-Chun Wu, Cheng-Shyuan Rau, Tsu-Hsiang Lu, Siou-Ling Tzeng, Yi-Chan Wu, Chia-Jung Wu, Chia-Wei Lin, Ching-Hua Hsieh   +7 more
doaj   +1 more source

Expression, purification, and functional characterisation of flagellin, a TLR5-ligand.

Veterinaria italiana, 2013
Flagellin, a Toll-like receptor 5 (TLR5)-ligand, is known for its activities like adjuvant, induction of pro-inflammatory cytokines and innate immunity. In this context, fliC gene of Salmonella Typhimurium was cloned into pET32a expression plasmid using in-house designed gene specific primers.
Irshad Ahmed Hajam, Pervaiz Ahmed Dar, Shanmugam Chandra Sekar, Rajakishore Nanda, Subodh Kishore, Veerakyathappa Bhanuprakash, Kondabattula Ganesh   +6 more
openaire   +3 more sources

Microbially Driven TLR5-Dependent Signaling Governs Distal Malignant Progression through Tumor-Promoting Inflammation [PDF]

, 2015
SummaryThe dominant TLR5R392X polymorphism abrogates flagellin responses in >7% of humans. We report that TLR5-dependent commensal bacteria drive malignant progression at extramucosal locations by increasing systemic IL-6, which drives mobilization of ...
Brencicova, Eva, Perales-Puchalt, Alfredo, Conejo Garcia, Jose R., Escovar Fadul, Ximena, Nguyen, Jenny M., Rabinovich, Gabriel A., Salatino, Mariana, Escovar-Fadul, Ximena, Perales Puchalt, Alfredo, Allegrezza, Michael J., Stephen, Tom L., Zhang, Rugang, Conejo-Garcia, Jose R., Svoronos, Nikolaos, Rabinovich, Gabriel Adrián, Cadungog, Mark G., Rutkowski, Melanie R., Tesone, Amelia J., Tchou, Julia   +18 more
core   +1 more source

Image1_Genome-wide identification and characterization of toll-like receptor 5 (TLR5) in fishes.PDF

, 2023
Toll-like receptors 5 (TLR5), a member of the toll-like receptors (TLRs) family, is a class of pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs).
Hongyan Kou (14335728), Li Lin (111038), Ming Chen (115604), Kai Zhang (102844), Haobin He (14335725), Rishen Liang (14335731)   +5 more
core   +1 more source

Pseudomonas evades immune recognition of flagellin in both mammals and plants.

PLoS Pathogens, 2011
The building blocks of bacterial flagella, flagellin monomers, are potent stimulators of host innate immune systems. Recognition of flagellin monomers occurs by flagellin-specific pattern-recognition receptors, such as Toll-like receptor 5 (TLR5) in ...
Bart W Bardoel, Sjoerd van der Ent, Michiel J C Pel, Jan Tommassen, Corné M J Pieterse, Kok P M van Kessel, Jos A G van Strijp   +6 more
doaj   +1 more source

DataSheet1_Genome-wide identification and characterization of toll-like receptor 5 (TLR5) in fishes.PDF

, 2023
Toll-like receptors 5 (TLR5), a member of the toll-like receptors (TLRs) family, is a class of pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs).
Hongyan Kou (14335728), Li Lin (111038), Ming Chen (115604), Kai Zhang (102844), Haobin He (14335725), Rishen Liang (14335731)   +5 more
core   +1 more source

Exploring the mechanism of intestinal bacterial translocation after severe acute pancreatitis: the role of Toll-like receptor 5

Gut Microbes
Severe acute pancreatitis (SAP)-induced intestinal bacterial translocation and enterogenic infection are among the leading causes of mortality in patients.
Cheng Zhang, Shiyin Chen, Zhien Wang, Jian Zhang, Wenqiao Yu, Yanshuai Wang, Weiwei Si, Yuwei Zhang, Yun Zhang, Tingbo Liang   +9 more
doaj   +1 more source

Expression of toll-like receptors in non-endemic nasopharyngeal carcinoma

BMC Cancer, 2019
Background Nasopharyngeal carcinoma (NPC) is a malignant disease with an enigmatic etiology. NPC associates with Epstein-Barr virus (EBV) and human papillomaviruses (HPVs), while immunological factors also play a role in carcinogenesis.
Miia Ruuskanen, Ilmo Leivo, Heikki Minn, Tero Vahlberg, Caj Haglund, Jaana Hagström, Heikki Irjala   +6 more
doaj   +1 more source