Results 101 to 110 of about 670 (133)

Activation of TLR5 induces podocyte apoptosis

Cell Biochemistry and Function, 2016
The apoptosis plays a critical role in a number of inflammatory disorders. Bacterial infection is one of the causes inducing apoptosis. This study aims to investigate the mechanism by which activation of TLR5 induces podocyte apoptosis. In this study, a podocyte cell line was cultured in RPMI1640 medium. The expression of TLR5 was assessed by real‐time
Xu, Lin, Haiting, Huang, Yanwu, You, Chunrong, Tang, Xiangjun, Gu, Meiying, Huang, Junhua, Tan, Jie, Wang   +7 more
openaire   +2 more sources

The flagellin-TLR5 axis: Therapeutic opportunities

Drug News & Perspectives, 2002
Motile bacteria synthesize large-sized surface structures known as flagella through the ordered polymerization of protein subunits. Flagellin, a protein of 40-60 kDa, is the principal constituent of the flagellum; each flagellum consists of approximately 20,000 flagellin molecules.
Liaudet, L., Deb, A., Pacher, P., Mabley, Jon, Murthy, K.G.K., Salzman, A.L., Szabo, C.   +6 more
openaire   +2 more sources

TLR5 takes aim at bacterial propeller

Nature Immunology, 2003
The Toll-like receptor (TLR) family targets pathogen-derived molecules in regions unlikely to change under selection pressures. For TLR5, which recognizes the protein flagellin, the function of the targeting motif is key.
openaire   +1 more source

TLR5 is not required for flagellin-mediated exacerbation of DSS colitis

Inflammatory Bowel Diseases, 2010
The two forms of human inflammatory bowel disease, Crohn's disease (CD) and ulcerative colitis (UC), are both associated with loss of tolerance to gut microbial antigens. The dominant antigen recognized by antibody and T-cell responses in patients with CD is bacterial flagellin. Flagellin is also the only known ligand for Toll-like receptor 5 (TLR5), a
Sabine M, Ivison, Megan E, Himmel, Gijs, Hardenberg, Paige A J, Wark, Arnawaz, Kifayet, Megan K, Levings, Theodore S, Steiner   +6 more
openaire   +2 more sources

Cyprinid‐specific duplicated membrane TLR5 senses dsRNA as functional homodimeric receptors

EMBO Reports, 2022
Jianguo Su, Jianguo Su, Yong-An Zhang
exaly  

TLR5

2012
Shaikh M. Atif, Stephen J. McSorley
openaire   +1 more source

Roseburia intestinalis and Its Metabolite Butyrate Inhibit Colitis and Upregulate TLR5 through the SP3 Signaling Pathway

Nutrients, 2022
Yanling Wei, Linling Lv, Yuting Tian
exaly  

Convergent Losses of TLR5 Suggest Altered Extracellular Flagellin Detection in Four Mammalian Lineages

Molecular Biology and Evolution, 2020
Heiko Stuckas, Nikolai Hecker, Michael Hiller   +2 more
exaly  

Consider TLR5 for new therapeutic development against COVID‐19

Journal of Medical Virology, 2020
Sang Soo Lee, Manojit Bhattacharya, Chiranjib Chakraborty   +2 more
exaly  

TLR5

2018
openaire   +1 more source