Results 91 to 100 of about 16,392 (208)

Recombinant TLR5 agonist CBLB502 promotes NK cell-mediated anti-CMV immunity in mice. [PDF]

PLoS ONE, 2014
Prior work using allogeneic bone marrow transplantation (allo-BMT) models showed that peritransplant administration of flagellin, a toll-like receptor 5 (TLR5) agonist protected murine allo-BMT recipients from CMV infection while limiting graft-vs-host ...
Mohammad S Hossain, Sampath Ramachandiran, Andrew T Gewirtz, Edmund K Waller   +3 more
doaj   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, Volume 2, Issue 2, Page 236-279, June 2026.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

RV suppresses TLR2 or TLR5 ligands-elicited IL-8 production without affecting TLR2 or TLR5 expression.

, 2012
(A) BEAS-2B cells were infected with RV39 or sham as described under figure 2 and then treated with Pam3CSK4 (TLR2 agonist), or flagellin (TLR5 agonist) and incubated for 6 h. IL-8 protein levels in the cell culture supernatants were determined by ELISA.
Benjamin L. Unger (130418), Andrea N. Faris (130419), Umadevi S. Sajjan (130425), Marc B. Hershenson (130424), Adam T. Comstock (130423), Shyamala Ganesan (130421)   +5 more
core   +1 more source

Colorectal Precancerous Lesions: Molecular Mechanisms, Research Tools, and Natural Product‐Based Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting‐edge research tools like multi‐omics and organoids, and highlights the potential and prospects of natural products such as berberine, resveratrol, and curcumin in preventing and intervening in colorectal carcinogenesis by modulating ...
Shunji Liu, Chujuan Cui, Lingdong Kong, Qiang Xu, Haibo Cheng, Lisha Zhou, Yang Sun   +6 more
wiley   +1 more source

Functional expression of TLR5 of different vertebrate species and diversification in intestinal pathogen recognition [PDF]

, 2018
Toll-like receptor 5 (TLR5) is activated by bacterial flagellins and plays a crucial role in the first-line defence against pathogenic bacteria and in immune homeostasis, and is highly conserved in vertebrate species.
Faber, Eugenia, Speidel, Yvonne, Brinkmann, Melanie M., Brinkmann, Melanie M, Tedin, Karsten, Josenhans, Christine   +5 more
core   +1 more source

Data_Sheet_1_Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella.pdf

, 2022
Leptospira (L.) interrogans are invasive bacteria responsible for leptospirosis, a worldwide zoonosis. They possess two periplasmic endoflagellae that allow their motility. L. interrogans are stealth pathogens that escape the innate immune recognition of
Albert I. Ko (90448), Laurence Fiette (421449), Julie Cagliero (133793), Martine Fanton d’Andon (4667083), Mathieu Picardeau (32310), Dirk Werling (119375), Frédérique Vernel-Pauillac (367975), Mariko Matsui (2806645), Catherine Werts (62319), Sophia Bortolussi (9227531), Marion Holzapfel (5877686), Cyrille Goarant (103331), Delphine Bonhomme (3742084), Ivo G. Boneca (9227534), Elsio A. Wunder (1348863)   +14 more
core   +1 more source

Vaginal Microbiota and Ovarian Cancer: A New Frontier in Immunomodulation and Diagnosis

Immunology, Volume 178, Issue 2, Page 209-217, June 2026.
Microbial imbalance, dysbiosis, plays a role in ovarian carcinogenesis by interacting with the immune system and altering inflammatory pathways, notably Th17 pathways. In contrast, eubiosis, characterised by Lactobacillus dominance, protects against infections and maintains hormone metabolism.
Wafa Babay, Mariem Garci, Ahmed Baligh Laaribi, Nabil Mathlouthi, Imene Ouzari   +4 more
wiley   +1 more source

The Outcome of Intracellular Selenomonas sputigena and its Impact on Gingival Keratinocytes

Molecular Oral Microbiology, Volume 41, Issue 3, Page 131-144, June 2026.
ABSTRACT Selenomonas sputigena is an understudied oral pathobiont associated with periodontitis and dental caries. We recently demonstrated that S. sputigena binds to gingival epithelial cells (GECs), where afterwards the bacterium causes robust in vitro pro‐inflammatory cytokine production and migration of monocytes and neutrophils.
Colin G. Hawkes, Travis J. Chiarelli, Doaa N. Abdallah, Grayson Way, Huiping Zhou, Jason A. Carlyon, Daniel P. Miller   +6 more
wiley   +1 more source

Controlling 3D Contractility via Engineered Fibrous Hydrogel Composites

Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.
A tunable composite contractile assembly (CCA) is developed that can permit or resist contraction without changing cell‐adhesion and density, unlike collagen whose inherent coupling of these ECM cues limits its use as a platform in contractility studies.
Karen L. Xu, Yuqi Zhang, Alysse DeFoe, Georgios Kotsaris, Brendan Stoeckl, Matthew D. Davidson, Jason A. Burdick, Robert L. Mauck   +7 more
wiley   +1 more source

Fish TLR5 develops a taste for viral RNA

EMBO reports, 2022
These days not only humans but also freshwater fish battle with infections by RNA viruses (Zou & Nie, 2017). This observation prompted Liao et al to turn their attention to viral recognition in Grass carp (Ctenopharyngodon idella), the most important cultivated freshwater fish with 5.7 million tons and 13 billion USD in fishery exports per year (FAO ...
openaire   +2 more sources