Results 31 to 40 of about 16,392 (208)
The role of Toll-like receptors in chemoradiotherapy-induced gastrointestinal mucositis
口腔疾病防治, 2021 Mucositis is a common gastrointestinal complication in cancer patients undergoing chemoradiotherapy, including oral mucositis and gastrointestinal mucositis, with clinical manifestations of oral ulcers, vomiting, diarrhea and pain that seriously reduce ...
JI Ling +3 more
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TRIF Modulates TLR5-dependent Responses by Inducing Proteolytic Degradation of TLR5 [PDF]
Journal of Biological Chemistry, 2010 Proteolytic modification of pattern recognition receptors and their signaling adaptor molecules has recently emerged as an essential cellular event to regulate immune and inflammatory responses. Here we show that the TIR domain containing adaptor-inducing interferon-beta (TRIF), an adaptor molecule mediating TLR3 signaling and MyD88-independent ...
Yoon Jeong, Choi +3 more
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Toll-like receptor 5-mediated signaling enhances liver regeneration in mice
Military Medical Research, 2021 Background Toll-like receptor 5 (TLR5)-mediated pathways play critical roles in regulating the hepatic immune response and show hepatoprotective effects in mouse models of hepatic diseases.
Wen Zhang +14 more
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TLR5 Stops Commensals in Their Tracks [PDF]
Cell Host & Microbe, 2013 IgA antibodies help maintain intestinal immune homeostasis with resident commensal species; however, the precise mechanisms regulating IgA induction and the epitopes recognized by these antibodies remain incompletely understood. In this issue of Cell Host & Microbe, Tyler et al.
Koch, Meghan A., Barton, Gregory M.
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Regulation of Toll-like receptor 5 gene expression and function on mucosal dendritic cells. [PDF]
PLoS ONE, 2012 Toll-like receptor (TLR) 5 has been shown to maintain intestinal homeostasis and regulate host defense against enterobacterial infection. However, how TLR5 expression is regulated and its function in the intestine have not been fully elucidated.
Ting Feng +3 more
doaj +1 more source
Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation
BMJ Open Gastroenterology, 2023 Objective Stellate cells are responsible for liver and pancreas fibrosis and strictly correlate with tumourigenesis. Although their activation is reversible, an exacerbated signalling triggers chronic fibrosis.
Malte Buchholz +6 more
doaj +1 more source
PLoS ONE, 2021 The toll-like receptor 5 (TLR5) is the most conserved important pattern recognition receptors (PRRs) often stimulated by bacterial flagellins and plays a major role in the first-line defense against invading pathogenic bacteria and in immune homeostasis.
Ajaya Kumar Rout +8 more
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Deglycosylation of eukaryotic-expressed flagellin restores adjuvanticity
npj Vaccines, 2023 Flagellin, the TLR5 agonist, shows potent adjuvant activities in diverse vaccines and immunotherapies. Vibrio vulnificus flagellin B expressed in eukaryotic cells (eFlaB) could not stimulate TLR5 signaling. Enzymatic deglycosylation restored eFlaB’s TLR5
Koemchhoy Khim +7 more
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Journal of Immunology Research, 2021 Enterogenous infection is a major cause of death during traumatic hemorrhagic shock (THS). It has been reported that Toll-like receptor 5 (TLR5) plays an integral role in regulating mucosal immunity and intestinal homeostasis of the microbiota.
Yun Zhang +10 more
doaj +1 more source
TLR5 risk-associated haplotype for canine inflammatory bowel disease confers hyper-responsiveness to flagellin. [PDF]
PLoS ONE, 2012 Single nucleotide polymorphisms (SNP) in the TLR5 gene have been associated with human inflammatory bowel disease (IBD) and animal models of this disease.
Aarti Kathrani +6 more
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