Results 31 to 40 of about 14,414 (179)

The Role of Flagellin B in Vibrio anguillarum-Induced Intestinal Immunity and Functional Domain Identification

Frontiers in Immunology, 2021
Vibrio anguillarum, an opportunistic pathogen of aquatic animals, moves using a filament comprised of polymerised flagellin proteins. Flagellins are essential virulence factors for V. anguillarum infection.
Quanxin Gao, Shaokui Yi, Yang Li, Jinping Luo, Qianqian Xing, Xia Yang, Ming Zhao, Minghua Min, Qian Wang, Yabing Wang, Lingbo Ma, Shiming Peng   +11 more
doaj   +1 more source

Salmonella flagella confer anti-tumor immunological effect via activating Flagellin/TLR5 signalling within tumor microenvironment

Acta Pharmaceutica Sinica B, 2021
Salmonella: mediated cancer therapy has achieved remarkable anti-tumor effects in experimental animal models, but the detailed mechanism remains unsolved. In this report, the active involvement of the host immune response in this process was confirmed by
Jianxiang Chen, Yiting Qiao, Guo Chen, Cunjie Chang, Heng Dong, Bo Tang, Xiawei Cheng, Xiufeng Liu, Zichun Hua   +8 more
doaj   +1 more source

CXCR1, TLR4, and CXCL8: Key Mediators of Pseudomonas aeruginosa Virulence in Wound and Burn Infections

Медицинская иммунология
Pseudomonas aeruginosa, an opportunistic pathogen of considerable clinical import, presents a formidable challenge to susceptible individuals, particularly within the confines of nosocomial settings.
Muslim Idan Mohsin, Hydar Muhsin Khalfa, Samer A. M. H. Al-Hilali, Israa Mahmood Kadhim Al-Zubaidy, Mahmood Shaker Jabbar, Karrar S. Zayed, Mohammed Jasim Al-Shamarti   +6 more
doaj   +1 more source

Common TLR5 Mutations Control Cancer Progression

Cancer Cell, 2015
The mechanisms regulating tumor-associated inflammation are incompletely understood. In this issue of Cancer Cell, Rutkowski and colleagues indicate that TLR5 signaling deficiency, which occurs in ∼10% of the population, changes interactions with commensal microbiota and deregulates a cascade of inflammatory events that can suppress or accelerate ...
Pfirschke, Christina, Garris, Christopher, Pittet, Mikaël   +2 more
openaire   +3 more sources

TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury

eLife, 2020
Lung disease causes significant morbidity and mortality, and is exacerbated by environmental injury, for example through lipopolysaccharide (LPS) or ozone (O3). Toll-like receptors (TLRs) orchestrate immune responses to injury by recognizing pathogen- or
Salik Hussain, Collin G Johnson, Joseph Sciurba, Xianglin Meng, Vandy P Stober, Caini Liu, Jaime M Cyphert-Daly, Katarzyna Bulek, Wen Qian, Alma Solis, Yosuke Sakamachi, Carol S Trempus, Jim J Aloor, Kym M Gowdy, W Michael Foster, John W Hollingsworth, Robert M Tighe, Xiaoxia Li, Michael B Fessler, Stavros Garantziotis   +19 more
doaj   +1 more source

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

TLR5 Activation Exacerbates Airway Inflammation in Asthma

Lung, 2020
Innate immune activation through exposure to indoor and outdoor pollutants is emerging as an important determinant of asthma severity. For example, household levels of the bacterial product lipopolysaccharide (LPS) are associated with increased asthma severity.
G. S. Whitehead, S. Hussain, R. Fannin, C. S. Trempus, C. L. Innes, S. H. Schurman, D. N. Cook, S. Garantziotis   +7 more
openaire   +3 more sources

Flagellin-independent effects of a Toll-like receptor 5 polymorphism in the inflammatory response to Burkholderia pseudomallei.

PLoS Neglected Tropical Diseases, 2019
BackgroundToll-like receptors (TLRs) are sentinel receptors of the innate immune system. TLR4 detects bacterial lipopolysaccharide (LPS) and TLR5 detects bacterial flagellin.
Amy K Dickey, Narisara Chantratita, Sarunporn Tandhavanant, Deirdre Ducken, Lara Lovelace-Macon, Sudeshna Seal, Johanna Robertson, Nicolle D Myers, Sandra Schwarz, Mark M Wurfel, Susanna Kosamo, T Eoin West   +11 more
doaj   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source

RETRACTED: Tlr5 deficiency exacerbates lupus-like disease in the MRL/lpr mouse model

Frontiers in Immunology
IntroductionLeaky gut has been linked to autoimmune disorders including lupus. We previously reported upregulation of anti-flagellin antibodies in the blood of lupus patients and lupus-prone mice, which led to our hypothesis that a leaky gut drives lupus
Razan M. Alajoleen, David N. Oakland, Rana Estaleen, Aida Shakeri, Ran Lu, Michael Appiah, Sha Sun, Jonathan Neumann, Shimako Kawauchi, Thomas E. Cecere, Ryan P. McMillan, Christopher M. Reilly, Xin M. Luo   +12 more
doaj   +1 more source