TLR5 risk-associated haplotype for canine inflammatory bowel disease confers hyper-responsiveness to flagellin. [PDF]
PLoS ONE, 2012 Single nucleotide polymorphisms (SNP) in the TLR5 gene have been associated with human inflammatory bowel disease (IBD) and animal models of this disease.
Aarti Kathrani +6 more
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Acta Neuropathologica Communications, 2020 Microglia are the primary immune-competent cells of the central nervous system (CNS) and sense both pathogen- and host-derived factors through several receptor systems including the Toll-like receptor (TLR) family.
Masataka Ifuku +11 more
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Regulation and Molecular Mechanism of TLR5 on Resistance to Escherichia coli F18 in Weaned Piglets
Animals, 2019 Toll-like receptor 5 (TLR5) plays an important role in immune system. In this study, we performed transcriptome analysis of the duodenum in E. coli F18-resistant and -sensitive Sutai weaned piglets and analyzed the differential expression of TLR5.
Chaohui Dai +5 more
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Genome-wide identification and characterization of toll-like receptor 5 (TLR5) in fishes
Frontiers in Genetics, 2023 Toll-like receptors 5 (TLR5), a member of the toll-like receptors (TLRs) family, is a class of pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs).
Kai Zhang +10 more
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The N‐terminal D1 domain of Treponema pallidum flagellin binding to TLR5 is required but not sufficient in activation of TLR5 [PDF]
Journal of Cellular and Molecular Medicine, 2019 AbstractSyphilis is a chronic bacterial infection caused by Treponema pallidum (T pallidum) and the pathogenesis that T pallidum infection induces immunopathological damages in skin and other tissues remains unclear. We have previously reported that recombinant flagellins of T pallidum can elicit IL‐6 and IL‐8 transcriptions via TLR5 pathway.
Man Xu +8 more
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Impaired TLR5 Functionality Is Associated with Survival in Melioidosis [PDF]
The Journal of Immunology, 2013 Abstract Melioidosis is infection caused by the flagellated saprophyte Burkholderia pseudomallei. TLR5 is a pathogen recognition receptor activated by bacterial flagellin. We studied a genetic variant that encodes a defective TLR5 protein, TLR51174C>T, to elucidate the role of TLR5 in melioidosis.
West, T +10 more
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Deletion of TLR5 results in spontaneous colitis in mice [PDF]
Journal of Clinical Investigation, 2007 Activation of TLRs by bacterial products results in rapid activation of genes encoding products designed to protect the host from perturbing microbes. In the intestine, which is colonized by a large and diverse population of commensal bacteria, TLR signaling may not function in a simple on/off mode. Here, we show that the flagellin receptor TLR5 has an
Matam, Vijay-Kumar +10 more
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The role of the C-terminal D0 domain of flagellin in activation of Toll like receptor 5. [PDF]
PLoS Pathogens, 2017 Flagellin is a wide-spread bacterial virulence factor sensed by the membrane-bound Toll-like receptor 5 (TLR5) and by the intracellular NAIP5/NLRC4 inflammasome receptor.
Vida Forstnerič +4 more
doaj +1 more source
TLR5 Signaling in the Regulation of Intestinal Mucosal Immunity
Journal of Inflammation Research, 2023 Toll-like receptor 5 (TLR5) is a pattern recognition receptor that specifically recognizes flagellin and consequently plays a crucial role in the control of intestinal homeostasis by activating innate and adaptive immune responses. TLR5 overexpression, on the other hand, might disrupt the intestinal mucosal barrier, which serves as the first line of ...
Feng,Shuyan +5 more
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TLR5 signaling enhances the proliferation of human allogeneic CD40-activated B cell induced CD4hiCD25+ regulatory T cells. [PDF]
PLoS ONE, 2013 Although diverse functions of different toll-like receptors (TLR) on human natural regulatory T cells have been demonstrated recently, the role of TLR-related signals on human induced regulatory T cells remain elusive.
Ping-Lung Chan +9 more
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