Direct Regulation of TLR5 Expression by Caveolin-1
Molecules and Cells, 2015 Toll-like receptor 5 (TLR5) is a specific receptor for microbial flagellin and is one of the most well-known receptors in the TLR family. We reported previously that TLR5 signaling is well maintained during aging and that caveolin-1 may be involved in TLR5 signaling in aged macrophages through direct interactions.
Lim, Jae Sung +5 more
openaire +4 more sources
Regulation and Molecular Mechanism of TLR5 on Resistance to Escherichia coli F18 in Weaned Piglets
Animals, 2019 Toll-like receptor 5 (TLR5) plays an important role in immune system. In this study, we performed transcriptome analysis of the duodenum in E. coli F18-resistant and -sensitive Sutai weaned piglets and analyzed the differential expression of TLR5.
Chaohui Dai +5 more
doaj +2 more sources
Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella [PDF]
Frontiers in Immunology, 2020 Leptospira (L.) interrogans are invasive bacteria responsible for leptospirosis, a worldwide zoonosis. They possess two periplasmic endoflagellae that allow their motility. L. interrogans are stealth pathogens that escape the innate immune recognition of
Marion Holzapfel +31 more
doaj +2 more sources
Genome-wide identification and characterization of toll-like receptor 5 (TLR5) in fishes [PDF]
Frontiers in Genetics, 2023 Toll-like receptors 5 (TLR5), a member of the toll-like receptors (TLRs) family, is a class of pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs).
Kai Zhang +10 more
doaj +2 more sources
RETRACTED: Tlr5 deficiency exacerbates lupus-like disease in the MRL/lpr mouse model [PDF]
Frontiers in ImmunologyIntroductionLeaky gut has been linked to autoimmune disorders including lupus. We previously reported upregulation of anti-flagellin antibodies in the blood of lupus patients and lupus-prone mice, which led to our hypothesis that a leaky gut drives lupus
Razan M. Alajoleen +12 more
doaj +2 more sources
Mucosal TLR5 activation controls healthspan and longevity [PDF]
Nature CommunicationsAbstractAddressing age-related immunological defects through therapeutic interventions is essential for healthy aging, as the immune system plays a crucial role in controlling infections, malignancies, and in supporting tissue homeostasis and repair. In our study, we show that stimulating toll-like receptor 5 (TLR5) via mucosal delivery of a flagellin ...
Jae Sung Lim +28 more
openaire +5 more sources
Host species adaptation of TLR5 signalling and flagellin recognition [PDF]
Scientific Reports, 2017 AbstractToll-like receptor 5 (TLR5) recognition of flagellin instigates inflammatory signalling. Significant sequence variation in TLR5 exists between animal species but its impact on activity is less well understood. Building on our previous research that bovine TLR5 (bTLR5) is functional, we compared human and bovine TLR5 activity and signalling in ...
Amin Tahoun +7 more
openaire +5 more sources
Charge-dependent localization of Toll-like receptor 5 at the plasma membrane [PDF]
Molecules and Cells: Proper subcellular localization of Toll-like receptors (TLRs) is essential for initiating appropriate innate immune responses against pathogens while avoiding self-reactivity.
Ji-Won Huh +4 more
doaj +2 more sources
HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia
Cell Reports, 2016 Infectious and sterile inflammatory diseases are correlated with increased levels of high mobility group box 1 (HMGB1) in tissues and serum. Extracellular HMGB1 is known to activate Toll-like receptors (TLRs) 2 and 4 and RAGE (receptor for advanced ...
Nabanita Das +8 more
doaj +3 more sources
TLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model [PDF]
Frontiers in ImmunologyIntroductionThe incidence of the autoimmune disease, type 1 diabetes (T1D), has been increasing worldwide and recent studies have shown that the gut microbiota are associated with modulating susceptibility to T1D.
James Alexander Pearson +5 more
doaj +2 more sources