Flagellin - Open Access .click

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Bacterial Flagellin as an Antigen and Immunogen

1972
The ability to recognize “foreignness” seems to have been a very early development in phylogeny. It has been shown that discrimination can occur even with single-cell organisms. It is only in vertebrates, however, that the ability has been highly developed as regards both specificity and variety in the level of discrimination.
Gordon Ada, Christopher R. Parish
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Flagellin Takes Its Toll

Science Signaling, 2012
Bacterially derived flagellin binds to an innate immune receptor to form a tail-to-tail heterodimeric signaling complex.
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The Bacterial Flagella and the Flagellar Protein Flagellin

Angewandte Chemie International Edition in English, 1973
AbstractIn comparison with the relatively complicated flagella of all nucleated organisms, most of the actively motile bacteria have very much simpler locomotion organelles. These flagella are long thin filaments with a helical superstructure, anchored at one end in the cell membrane. Helical waves pass along the flagella in the distal direction during
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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5