Essential Role of CFAP53 in Sperm Flagellum Biogenesis
Frontiers in Cell and Developmental Biology, 2021 The sperm flagellum is essential for male fertility. Despite vigorous research progress toward understanding the pathogenesis of flagellum-related diseases, much remains unknown about the mechanisms underlying the flagellum biogenesis itself.
Bingbing Wu +33 more
doaj +2 more sources
Structures of the stator complex that drives rotation of the bacterial flagellum
Nature Microbiology, 2020 The bacterial flagellum is the prototypical protein nanomachine and comprises a rotating helical propeller attached to a membrane-embedded motor complex.
Justin C Deme +2 more
exaly +3 more sources
Giant FAZ10 is required for flagellum attachment zone stabilization and furrow positioning in Trypanosoma brucei [PDF]
Journal of Cell Science, 2017 The flagellum and flagellum attachment zone (FAZ) are important cytoskeletal structures in trypanosomatids, being required for motility, cell division and cell morphogenesis.
Baqui, Munira M.A. +3 more
core +2 more sources
An orphan kinesin controls trypanosome morphology transitions by targeting FLAM3 to the flagellum.
PLoS Pathogens, 2018 Trypanosoma brucei undergoes life cycle form transitions from trypomastigotes to epimastigotes in the insect vector by re-positioning the mitochondrial genome and re-locating the flagellum and flagellum-associated cytoskeletal structures.
Tai An, Ziyin Li
doaj +2 more sources
APEX2 Proximity Proteomics Resolves Flagellum Subdomains and Identifies Flagellum Tip-Specific Proteins in Trypanosoma brucei [PDF]
mSphere, 2020 Sleeping sickness is a neglected tropical disease caused by the protozoan parasite Trypanosoma brucei. The disease disrupts the sleep-wake cycle, leading to coma and death if left untreated. T.
D. E. Vélez-Ramírez +9 more
semanticscholar +6 more sources
The Role of the Bacterial Flagellum in Adhesion and Virulence
Biology, 2013 The bacterial flagellum is a complex apparatus assembled of more than 20 different proteins. The flagellar basal body traverses the cell wall, whereas the curved hook connects the basal body to the whip-like flagellar filament that protrudes several µm ...
Benita Westerlund-Wikström
exaly +2 more sources
Flagellum-driven cargoes: Influence of cargo size and the flagellum-cargo attachment geometry
PLOS ONE, 2023 The beating of cilia and flagella, which relies on an efficient conversion of energy from ATP-hydrolysis into mechanical work, offers a promising way to propel synthetic cargoes. Recent experimental realizations of such micro-swimmers, in which micron-sized beads are propelled by isolated and demembranated flagella from the green algae Chlamydomonas ...
Albert Bae +4 more
openalex +8 more sources
Structural Insights into Type III Secretion Systems of the Bacterial Flagellum and Injectisome.
Annual Review of Microbiology, 2023 Two of the most fascinating bacterial nanomachines-the broadly disseminated rotary flagellum at the heart of cellular motility and the eukaryotic cell-puncturing injectisome essential to specific pathogenic species-utilize at their core a conserved ...
L. Worrall, D. D. Majewski, N. Strynadka
semanticscholar +1 more source
Ccdc38 is required for sperm flagellum biogenesis and male fertility in mice.
Development, 2022 The sperm flagellum is essential for male fertility, and defects in flagellum biogenesis are associated with male infertility. Deficiency of CCDC42 is specifically associated with malformation of mouse sperm flagella.
Ruidan Zhang +12 more
semanticscholar +1 more source
Basal body positioning is controlled by flagellum formation in Trypanosoma brucei. [PDF]
PLoS ONE, 2007 To perform their multiple functions, cilia and flagella are precisely positioned at the cell surface by mechanisms that remain poorly understood. The protist Trypanosoma brucei possesses a single flagellum that adheres to the cell body where a specific ...
Sabrina Absalon +9 more
doaj +1 more source