Results 31 to 40 of about 37,257 (258)

CNS damage biomarkers in cerebrospinal fluid and other findings from a patient cohort enriched for suspected autoimmune psychiatric disease

Journal of Affective Disorders Reports, 2023
Objective: To describe the prevalence of central nervous system (CNS) pathology in a psychiatric patient cohort enriched for clinical red flags of suspected autoimmune psychiatric disease, we explored associations between CNS damage biomarkers in ...
Janet Cunningham, Mikaela Syk, Emma Tornvind, Maike Gallwitz, David Fällmar, Åsa Amandusson, Holger Rothkegel, Torsten Danfors, Måns Thulin, Annica J. Rasmusson, Simon Cervenka, 1, Tom Pollack, Ludger Tebartz van Elst, Dominique Endres, Robert Bodén, Björn M. Nilsson, Joachim Burman   +16 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The Language of the Sea: Flags and Identities in Early Modern Dutch Marine Painting

Early Modern Low Countries, 2020
This article investigates the convergence between early modern Dutch marine painting and contemporaneous political identities and diplomatic conventions.
David Onnekink
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Lower the Flag: A Qualitative Analysis of Behavioral Alerts in the Electronic Health Record

Health Equity
Background: Behavioral alerts (BAs) are electronic health record communication tools used to notify clinicians and staff about patient behavioral incidents. Despite their widespread presence, limited research exists on the content and use of BAs. Methods:
Zoë Kopp, Irina Kryzhanovskaya, Maria E. Garcia   +2 more
doaj   +1 more source

Identifying Compiler and Optimization Level in Binary Code From Multiple Architectures

IEEE Access, 2021
While compiling a native application, different compiler flags or optimization levels can be configured. This choice depends on the different requirements.
Davide Pizzolotto, Katsuro Inoue
doaj   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Comparable efficacy of counselling, equine-assisted learning and nature-based interventions in family support

Academia Mental Health & Well-Being
This study presents findings from an analysis of the impact of three different intervention types referred to as part of the Supporting Families Program in England (SFP), which supports families experiencing multiple challenges, including ...
S. Kezia Sullivan, Ann Hemingway
doaj   +1 more source