Results 111 to 120 of about 787,641 (342)

Stationary solutions and asymptotic flatness I

, 2013
In this article and its sequel we discuss the asymptotic structure of space-times representing isolated bodies in General Relativity. Such space-times are usually required to be asymptotically flat (AF), and thus to have a prescribed type of asymptotic ...
Reiris, Martin
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Experimental Study on Surface Roughness and Flatness in Lapping of AISI 52100 Steel [PDF]

International Journal of Advanced Design and Manufacturing Technology, 2016
Lapping is one of the most important polishing processes which can be used to fabricate flat and smooth surfaces. In this paper, the effect of lapping characteristics and mesh number of abrasive particles are studied on the surface roughness and flatness
Masoud Farahnakian, H. ُُShahrajabian
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Theoretical Study of Asymmetric Bending Force on Metal Deformation in Cold Rolling

Metals
A three-dimensional elastic–plastic finite element model of a six-roll cold rolling mill has been developed using the finite element software ABAQUS. The actual parameters of the rolling mill have been incorporated into the finite element model, with the
Zhuwen Yan, Shuaizhen Pan, Yingxin Tang, Wenjun Cao   +3 more
doaj   +1 more source

Flat Parallelization

CoRR, 2017
There are two intertwined factors that affect performance of concurrent data structures: the ability of processes to access the data in parallel and the cost of synchronization. It has been observed that for a large class of "concurrency-unfriendly" data structures, fine-grained parallelization does not pay off: an implementation based on a single ...
Vitaly Aksenov, Petr Kuznetsov
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Cluster analysis of strip flatness characteristics for ultra-wide cold rolling mills

工程科学学报, 2016
In order to master the flatness characteristics of strips with different widths for ultra-wide tandem cold rolling mills, taking the sufficient flatness detection data of 1900 mm strips from 2180 mm cold rolling mills as a research object and considering
LI Hong-bo, BAO Ren-ren, ZHANG Jie, JIA Sheng-hui, CHU Yu-gang, LIU Hai-jun   +5 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source