Seasonal Changes in the Tetrodotoxin Content of the Flatworm Planocera multitentaculata
Marine Drugs, 2017 Tetrodotoxin (TTX) is a potent neurotoxin that acts specifically on voltage-gated sodium channels on excitable membranes of muscle and nerve tissues. The biosynthetic process for TTX is unclear, although marine bacteria are generally thought to be the ...
Shiro Itoi
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Profiling G protein-coupled receptors of Fasciola hepatica identifies orphan rhodopsins unique to phylum Platyhelminthes [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2018 G protein-coupled receptors (GPCRs) are established drug targets. Despite their considerable appeal as targets for next-generation anthelmintics, poor understanding of their diversity and function in parasitic helminths has thwarted progress towards GPCR-
Paul McVeigh +8 more
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The exceptional stem cell system of
Frontiers in Zoology, 2007 Background Flatworms are characterized by an outstanding stem cell system. These stem cells (neoblasts) can give rise to all cell types including germ cells and power the exceptional regenerative capacity of many flatworm species.
Eichberger Paul +8 more
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Genome and transcriptome of the regeneration-competent flatworm, Macrostomum lignano [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 The free-living flatworm, Macrostomum lignano has an impressive regenerative capacity. Following injury, it can regenerate almost an entirely new organism because of the presence of an abundant somatic stem cell population, the neoblasts.
James Gurtowski +2 more
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Toxic Flatworm Egg Plates Serve as a Possible Source of Tetrodotoxin for Pufferfish
Toxins, 2019 The pufferfish Takifugu niphobles (at present Takifugu alboplumbeus) possesses highly concentrated tetrodotoxin (TTX), an extremely potent neurotoxin that provides effective protection from predators, at least at the larval stages. However, the source of
Taiki Okabe, Rei Suo, Haruo Sugita
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TTX-Bearing Planocerid Flatworm (Platyhelminthes: Acotylea) in the Ryukyu Islands, Japan
Marine Drugs, 2018 Polyclad flatworms comprise a highly diverse and cosmopolitan group of marine turbellarians. Although some species of the genera Planocera and Stylochoplana are known to be tetrodotoxin (TTX)-bearing, there are few new reports.
Shiro Itoi, Haruo Sugita
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Tracking karyotype dynamics by flow cytometry reveals de novo chromosome duplications in laboratory cultures of Macrostomum lignano [PDF]
Biology OpenStijn Mouton +2 more
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Microbiology Spectrum, 2022 Because parasites have an inextricable relationship with their host, they have the potential to serve as viral reservoirs or facilitate virus host shifts.
Nolwenn M. Dheilly +3 more
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Animals, 2021 Fasciolosis caused by Fasciola hepatica is a major global disease of livestock and an important neglected helminthiasis of humans. Infection arises when encysted metacercariae are ingested by the mammalian host. Within the intestine, the parasite excysts
Tara Barbour +4 more
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First Detection of Tetrodotoxins in the Cotylean Flatworm Prosthiostomum trilineatum
Marine Drugs, 2021 Several polyclad flatworm species are known to contain high levels of tetrodotoxin (TTX), but currently TTX-bearing flatworms seem to be restricted to specific Planocera lineages belonging to the suborder Acotylea.
Rei Suo +8 more
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