Calculation of the Geometries and Infrared Spectra of the Stacked Cofactor Flavin Adenine Dinucleotide (FAD) as the Prerequisite for Studies of Light-Triggered Proton and Electron Transfer [PDF]
Biomolecules, 2020 Flavin cofactors, like flavin adenine dinucleotide (FAD), are important electron shuttles in living systems. They catalyze a wide range of one- or two-electron redox reactions.
OSCAR Ventura +2 more
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Quantum theory of a potential biological magnetic field sensor: Radical pair mechanism in flavin adenine dinucleotide biradicals [PDF]
Computational and Structural Biotechnology JournalRecent studies in vitro and in vivo suggest that flavin adenine dinucleotide (FAD) on its own might be able to act as a biological magnetic field sensor.
Amirhosein Sotoodehfar +3 more
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Driving the conversion of phytosterol to 9α-hydroxy-4-androstene-3,17-dione in Mycolicibacterium neoaurum by engineering the supply and regeneration of flavin adenine dinucleotide [PDF]
Biotechnology for Biofuels and Bioproducts, 2023 Background The conversion of phytosterols to steroid synthons by engineered Mycolicibacteria comprises one of the core steps in the commercial production of steroid hormones.
Lu Song +6 more
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Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases [PDF]
Epigenetics, 2017 Until 2004, many researchers believed that protein methylation in eukaryotic cells was an irreversible reaction. However, the discovery of lysine-specific demethylase 1 in 2004 drastically changed this view and the concept of chromatin regulation.
Hideaki Niwa, Takashi Umehara
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Flavin adenine dinucleotide rescues the phenotype of frataxin deficiency.
PLoS ONE, 2010 BackgroundFriedreich ataxia is a neurodegenerative disease caused by the lack of frataxin, a mitochondrial protein. We previously demonstrated that frataxin interacts with complex II subunits of the electronic transport chain (ETC) and putative ...
Pilar Gonzalez-Cabo +2 more
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The crystal structure of human ferroptosis suppressive protein 1 in complex with flavin adenine dinucleotide and nicotinamide adenine nucleotide [PDF]
MedCommFerroptosis is a recently discovered form of regulated cell death characterized by its distinct dependence on iron and the peroxidation of lipids within cellular membranes. Ferroptosis plays a crucial role in physiological and pathological situations and
Shijian Feng +8 more
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pH-Dependent Flavin Adenine Dinucleotide and Nicotinamide Adenine Dinucleotide Ultraviolet Resonance Raman (UVRR) Spectra at Intracellular Concentration [PDF]
Applied Spectroscopy, 2021 Janina Kneipp, Virginia Merk
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Flavin-dependent monooxygenases as versatile biocatalysts in biomanufacturing: mechanisms, engineering, and applications [PDF]
Biotechnology for Biofuels and BioproductsFlavin-dependent monooxygenases (FMOs) are versatile oxidative biocatalysts that catalyze a wide array of oxygenation reactions, such as hydroxylation, epoxidation, Baeyer–Villiger oxidation, and halogenation.
Yong Li +7 more
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Plant Cryptochromes Illuminated: A Spectroscopic Perspective on the Mechanism
Frontiers in Chemistry, 2021 Plant cryptochromes are central blue light receptors for the control of land plant and algal development including the circadian clock and the cell cycle.
Lukas Goett-Zink +2 more
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A fluorescence sensor for nitroreductase detection in hypoxic cells and zebrafish
Results in Chemistry, 2021 Nitroreductase (NTR) is a type of cytoplasmic enzyme that depends on flavin mononucleotide or flavin adenine dinucleotide, and that is widely present in tumor cells where it increases during hypoxia. NTR can effectively reduce aromatic nitro compounds to
Wan Sun +7 more
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