Zika virus infection reprograms global transcription of host cells to allow sustained infection. [PDF]
, 2017 Zika virus (ZIKV) is an emerging virus causally linked to neurological disorders, including congenital microcephaly and Guillain-Barré syndrome. There are currently no targeted therapies for ZIKV infection.
Bansal, Vikas +5 more
core +2 more sources
Perspectives for the Treatment of Infections withFlaviviridae [PDF]
Clinical Microbiology Reviews, 2000 SUMMARYThe family Flaviviridae contains three genera: Hepacivirus, Flavivirus, and Pestivirus. Worldwide, more than 170 million people are chronically infected with Hepatitis C virus and are at risk of developing cirrhosis and/or liver cancer. In addition, infections with arthropod-borne flaviviruses (such as dengue fever, Japanese encephalitis, tick ...
P, Leyssen, E, De Clercq, J, Neyts
openaire +3 more sources
International Journal of Molecular SciencesThe members of the Flaviviridae family are becoming an emerging threat for public health, causing an increasing number of infections each year and requiring effective treatment.
A. Latanova +2 more
semanticscholar +1 more source
Optimal control of a dengue epidemic model with vaccination [PDF]
, 2011 We present a SIR+ASI epidemic model to describe the interaction between human and dengue fever mosquito populations. A control strategy in the form of vaccination, to decrease the number of infected individuals, is used.
Delfim F. M. Torres +3 more
core +2 more sources
Implementation of IFPTML Computational Models in Drug Discovery Against Flaviviridae Family
Journal of Chemical Information and ModelingThe Flaviviridae family consists of single-stranded positive-sense RNA viruses, which contains the genera Flavivirus, Hepacivirus, Pegivirus, and Pestivirus.
Yendrek Velásquez-López +3 more
semanticscholar +1 more source
Vaccine development for mosquito-borne viral diseases
Frontiers in Immunology, 2023 Mosquito-borne viral diseases are a group of viral illnesses that are predominantly transmitted by mosquitoes, including viruses from the Togaviridae and Flaviviridae families.
Zhiwei Huang +7 more
doaj +1 more source
The interferon-stimulated gene IFITM3 restricts West Nile virus infection and pathogenesis [PDF]
, 2016 The interferon-induced transmembrane protein (IFITM) family of proteins inhibit infection of several different enveloped viruses in cell culture by virtue of their ability to restrict entry and fusion from late endosomes.
Bradbury LE +6 more
core +2 more sources
Mapping glycoprotein structure reveals defining events in the evolution of the Flaviviridae
bioRxivViral glycoproteins drive membrane fusion in enveloped viruses and determine host range, tissue tropism and pathogenesis. Despite their importance, there is a fragmentary understanding of glycoproteins within the Flaviviridae; for many species the ...
Jonathon C. O. Mifsud +6 more
semanticscholar +1 more source
Arboviruses and the challenge to establish systemic and persistent infections in competent mosquito vectors : the interaction with the RNAi mechanism [PDF]
, 2019 Arboviruses are capable to establish long-term persistent infections in mosquitoes that do not affect significantly the physiology of the insect vectors. Arbovirus infections are controlled by the RNAi machinery via the production of viral siRNAs and the
Kolliopoulou, Anna +3 more
core +1 more source
Proposed revision to the taxonomy of the genus Pestivirus, family Flaviviridae
Journal of General Virology, 2017 We propose the creation of seven new species in the genus Pestivirus (family Flaviviridae) in addition to the four existing species, and naming species in a host-independent manner using the format Pestivirus X. Only the virus species names would change;
Donald B. Smith +10 more
semanticscholar +1 more source