Results 61 to 70 of about 20,416 (183)

Apo B100 similarities to viral proteins suggest basis for LDL-DNA binding and transfection capacity

Journal of Lipid Research, 2010
LDL mediates transfection with plasmid DNA in a variety of cell types in vitro and in several tissues in vivo in the rat. The transfection capacity of LDL is based on apo B100, as arginine/lysine clusters, suggestive of nucleic acid-binding domains and ...
Juan Guevara, Jr., Nagindra Prashad, Boris Ermolinsky, John W. Gaubatz, Dongcheul Kang, Andrea E. Schwarzbach, David S. Loose, Natalia Valentinova Guevara   +7 more
doaj   +1 more source

ProTides for Antiviral Activity Beyond Liver Cells

Chemistry – A European Journal, Volume 32, Issue 21, 1 June 2026.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel, Adrian Humboldt, Heeyoung Kim, Carl J. M. Schölzel, Ralf Bartenschlager, Clemens Richert   +5 more
wiley   +1 more source

Evidências sorológicas da circulação do arbovírus Rocio (Flaviviridae) na Bahia

Revista da Sociedade Brasileira de Medicina Tropical, 1997
Oito casos com anticorpos anti-Rocio são descritos, de quatro cidades do Estado da Bahia, sendo seis portadores de anticorpos IgG (IH e TN) e dois IgM (ELISA e TN).
Andréa Straatmann, Sandro Santos-Torres, Pedro F.C. Vasconcelos, Amélia P.A. Travassos da Rosa, Sueli G. Rodrigues, José Tavares-Neto   +5 more
doaj   +1 more source

Hepatitis C Virus Infection in the PERSIAN Guilan Cohort Study Population: Intrafamilial Transmission Incidence and Response to SOVODAK‐Based Therapy

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Hepatitis C virus (HCV) infection is one of the leading causes of liver‐related diseases such as cirrhosis and hepatocellular carcinoma. Despite ongoing efforts, no effective vaccine has been developed to date due to the virus's high mutation rate and extensive genetic variability. This study aimed to determine the prevalence of HCV
Farahnaz Joukar, Sara Yeganeh, Narges Eslami, Fariborz Mansour‐Ghanaei   +3 more
wiley   +1 more source

Reverse Genetics of Orthoflaviviruses: Strategies for Constructing Functional or Infectious cDNA

Journal of Medical Virology, Volume 98, Issue 6, June 2026.
ABSTRACT Reverse genetics (RG) systems have transformed RNA virus research by enabling the recovery of recombinant viruses entirely from cloned cDNA. These platforms allow precise, hypothesis‐driven manipulation of viral genomes and support systematic phenotypic analyses in vitro and in vivo.
Young‐Min Lee
wiley   +1 more source

When conservation meets contagion: Mapping yellow fever risk to guide vaccination in an endangered primate

Journal of Applied Ecology, Volume 63, Issue 6, June 2026.
Spatial projections revealed high‐risk areas for YF transmission, highlighting priority zones for targeted vaccination efforts in GLTs. By integrating disease ecology into conservation planning, this study offers a scalable framework for spatially informed interventions aimed at mitigating disease‐driven declines in threatened species.
Maxime Pierron, Aurore Ponchon, Carlos R. Ruiz‐Miranda, Andreia Martins, Cédric Sueur, Valéria Romano   +5 more
wiley   +1 more source

Methods for Lipid Droplet Biophysical Characterization in Flaviviridae Infections

Frontiers in Microbiology, 2018
Lipid droplets (LDs) are intracellular organelles for neutral lipid storage, originated from the endoplasmic reticulum. They play an essential role in lipid metabolism and cellular homeostasis.
Ana S. Martins, Ivo C. Martins, Nuno C. Santos   +2 more
doaj   +1 more source

A Modular Design of a Cholera Toxin B Subunit‐Scaffolded Sub‐Virion Nanoparticle Vaccine Against West Nile Virus

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
A recombinant West Nile virus (WNV) subunit vaccine was developed by displaying ED3 on a CTB scaffold. The fusion protein formed soluble nanoparticles in E. coli, eliciting strong, balanced, and specific neutralizing antibodies without cross‐reactivity, offering a safe, scalable subunit vaccine platform.
Hyun Byun, Tae Hoon Kim, Jemin Sung, Jung‐Min Lee, Sang‐Mu Shim, Sin Hae Kang, Hanul Kang, Dah Hyun Moon, Seong Hyun Park, Doda Kim, Sung Jae Kim, Seunghoo Kim, Gyoonhee Han, Baik Lin Seong   +13 more
wiley   +1 more source

Citizen science reveals host‐switching in louse flies and keds (Diptera: Hippoboscidae) during a period of anthropogenic change

Medical and Veterinary Entomology, Volume 40, Issue 2, Page 305-322, June 2026.
A study of louse flies in the United Kingdom, Isle of Man, and Ireland found 212 different interactions between Hippoboscidae and their hosts, of which 70 were previously unrecorded. No louse flies were found on aquatic species of birds. Host‐switching to gulls (Laridae) has occurred during a period in which these species have started relying on ...
Denise C. Wawman, Adrian L. Smith, Ben C. Sheldon   +2 more
wiley   +1 more source

Shrubs and trees as natural insect protection for grazing animals in Switzerland and the alpine region: A systematic review of in vitro, in vivo and clinical trials Sträucher und Bäume als natürlicher Insektenschutz für Weidetiere in der Schweiz und im Alpenraum: Eine systematische Literaturübersicht über in vitro‐, in vivo‐ und klinische Studien

Medical and Veterinary Entomology, Volume 40, Issue 2, Page 221-245, June 2026.
Biting or irritating insects are a threat to the health and welfare of grazing animals. This systematic review reveals that several shrubs and bushes growing in the alpine area have insecticidal, insect‐repellent and/or attractant properties. The alder Alnus glutinosa, juniper Juniperus communis, spruce Picea abies and walnut Juglans regia are ...
Theresa Schlittenlacher, Sofie Egli, Michael Walkenhorst, Veronika Maurer   +3 more
wiley   +1 more source