Results 41 to 50 of about 24,181 (166)
, 2022 The general sociodemographic characteristics of Flaviviridae virus infections during pediatric hospitalizations from December 2015 to December 2020.
Guoshuang Feng (4725078) +6 more
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ChemistrySelect, Volume 11, Issue 33, 1 September 2026.This narrative review analyzes DENV molecular targets, including structural proteins (C, prM/M, E), non‐structural components (NS1NS5), and host factors, alongside small‐molecule candidates in preclinical and clinical phases. Owing to high structural conservation, the NS2B‐NS3 protease and NS5 (RdRp/MTase) remain primary drug discovery focuses, while ...
Aryane Lucia da Silva Aguiar De Oliveira +8 more
wiley +1 more source
Design and Synthesis of a Potent, Cell Active Purine‐Based Amidoxime Against the Dengue Virus
ChemistrySelect, Volume 11, Issue 36, 22 September 2026.Scaffold hopping from our previous indolazepinone hit exemplifies purine SP‐835G with DENV2 EC50 0.1 µM, CC50>100 µM, clogP 3.61. Docking studies support its amidine metabolite operates as an allosteric inhibitor of DENV(pro). A flexible ether linker appears pivotal for enhancing binding and activity.
Dimitrios Kiousis +8 more
wiley +1 more source
Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.We developed sensitive real‐time PCR assays for West Nile virus and Usutu virus to screen bird and human samples in Finland. Although no positive samples were detected, active migratory flyways and recent cases in neighbouring countries highlight the risk of future introduction and the need for continued surveillance.
Ruut Joensuu +6 more
wiley +1 more source
, 2018 Viruses belonging to the Flaviviridae family have been an important health concern for humans, animals and birds alike. No specific treatment is available yet for many of the viral infections caused by the members of this family.
Akaberi, Dario +2 more
core +2 more sources
Compounds for the treatment or prevention of infection by Flaviviridae
, 2008 The present invention provides compounds, pharmaceutically acceptable derivatives thereof and pharmaceutical compositions that are useful as Flaviviridae replication ...
Paglietti, Giuseppe +3 more
core
, 2018 Infections with viruses in the Flaviviridae family have a vast global and economic impact because of the high morbidity and mortality. The pathogenesis of Flaviviridae infections is very complex and not fully understood because these viruses can inhibit ...
Wei Zhang +11 more
core +1 more source
Mapping glycoprotein structure reveals defining events in the evolution of the Flaviviridae [PDF]
Viral glycoproteins drive membrane fusion in enveloped viruses and determine host range, tissue tropism and pathogenesis. Despite their importance, there is a fragmentary understanding of glycoproteins within the Flaviviridae; for many species the ...
Costa, Vincenzo A. +6 more
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Interplay between Inflammation and Cellular Stress Triggered by Flaviviridae Viruses [PDF]
, 2016 Flaviviruses, from Flaviviridae virus family, comprises several human pathogens, including Dengue, Zika, Yellow Fever, West Nile and Japanese Encephalitis viruses.
Luciana Barros Arruda +5 more
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Implementation of IFPTML Computational Models in Drug Discovery Against Flaviviridae Family
The Flaviviridae family consists of single-stranded positive-sense RNA viruses, which contains the genera Flavivirus, Hepacivirus, Pegivirus, and Pestivirus.
Ruiz Escudero, Andrea +7 more
core +1 more source