Results 31 to 40 of about 24,181 (166)

Computational systems biology analysis of changes in gene regulation during Flaviviridae virus infection

, 2013
Flaviviridae viruses cause thousands of deaths and threaten millions of people in the world each year. Despite widespread studies, the underlying host-virus functional interactions in the Flaviviridae virus infected host cells are poorly understood ...
Li, Minming
core   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

RNA viral protein structure database: A comprehensive and user‐friendly web database for RNA viral protein structures

iMetaOmics, Volume 3, Issue 3, September 2026.
Given the central role of protein structures in RNA virus biology, the RNA viral protein structure database (RVPSD, https://virus.9itsg.net) integrates taxonomic classification, viral nucleotide and protein sequences, functional annotations, and predicted three‐dimensional protein structures.
Qiangzhen Yang, Zhongshuai Tian, Tao Hu, Jiangrong Lou, Hengcong Liu, Edward C. Holmes, Yongyong Shi, Juan Li, Weifeng Shi   +8 more
wiley   +1 more source

Rewiring cellular networks by members of the Flaviviridae family

, 2018
Members of the Flaviviridae virus family comprise a large group of enveloped viruses with a single-strand RNA genome of positive polarity. Several genera belong to this family, including the Hepacivirus genus, of which hepatitis C virus (HCV) is the ...
Cortese M., Acosta E. G., Bartenschlager R., Neufeldt C. J.   +3 more
core   +1 more source

The small compound inhibitor K22 displays broad antiviral activity against different members of the family Flaviviridae and offers potential as pan-viral inhibitor. [PDF]

, 2018
The virus family Flaviviridae encompasses several viruses, including (re)emerging viruses which cause widespread morbidity and mortality throughout the world.
Engler, O, Pfaender, Stephanie, Vielle, Nathalie J., Vieyres, G, Garcia Nicolas, Obdulio, García-Nicolás, Obdulio, Ebert, Nadine, Gaschen, Véronique, Alves, Marco P, V'kovski, Philip, Stalder, Hanspeter, Summerfield, Artur, Vielle, Nathalie J, Todt, Daniel, Thiel, Volker, Vieyres, Gabrielle, Todt, D, Alves, Marco, Stoffel, Michael, Züst, Roland, Schweizer, Matthias, Pfänder, Stephanie, Engler, Olivier, Züst, R, Pietschmann, T, Portmann, Jasmine, Pietschmann, Thomas   +26 more
core   +2 more sources

Dengue Seroprevalence Among Blood Donors in the Lazio Region (Italy): Is There an Iceberg Beneath the Surface?

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT During 2023, dengue virus (DENV) autochthonous circulation was detected in Lazio, Italy. To investigate the magnitude of the phenomenon, anti‐DENV serological status of blood donors residing in previously affected Rome municipalities was evaluated.
Martina Spaziante, Lugi Rosa, Francesca Colavita, Ilaria Mussetto, Gabriella De Carli, Valentina Vantaggio, Alessandro Agresta, Sabrina Coen, Silvia Cammisa, Alessandra D'Abramo, Gaetano Maffongelli, Stefania Vaglio, Stefano Iaboni, Ida Casorelli, Luca Mele, Luciana Teofili, Paola Scognamiglio, Andrea Siddu, Emanuele Nicastri, Fabrizio Maggi, Enrico Girardi, ARBODONORS Working Group, Deborah Ilaria Gadaleta, Diletta D'Epiro, Enrico Duranti, Manuela Cornacchia, Tecla Maria Fontana, Maria Laura Foddai, Francesca Frangiolini, Giuseppina Antonia Natale, Mafalda De Rienzo, Francesco Vairo   +31 more
wiley   +1 more source

Broad-Spectrum Inhibitor of Viruses in the Flaviviridae Family

, 2005
The viruses in the Flaviviridae family have been associated with human and animal diseases. In this report, we demonstrate that compound 2-amino-8-(β-d-ribofuranosyl) imidazo [1,2-a]-s-triazine-4-one (ZX-2401) was capable of inhibiting the production in ...
Ali, S., Craig D. Shimasaki, Joshua O. Ojwang, Shoukath Ali, Robert W. Sidwell, Donald F. Smee, John D. Morrey, Sidwell, R. W., Smee, Donald F., Ojwang, J. O., Morrey, John D., Shimasaki, C. D.   +11 more
core   +1 more source

Renaming of the genus Flavivirus to Orthoflavivirus and extension of binomial species names within the family Flaviviridae

, 2023
This review provides a summary of the recently ratified changes to genus and species nomenclature within the virus family Flaviviridae along with reasons for these changes.
Karganova, Galina G., Blitvich, Bradley, Allison Imrie, Kuhn, Jens, Martin Beer, Postler, Thomas S., Simmonds, Peter, Xavier de Lamballerie, Jack T. Stapleton, Peter Simmonds, Philippe Lemey, J. Felix Drexler, Amit Kapoor, Kapoor, Amit, Blitvich, Bradley J., Jens H. Kuhn, Lohmann, Volker, Smith, Donald B., Galina G. Karganova, de Lamballerie, Xavier, Donald B. Smith, Thomas S. Postler, Bukh, Jens, Lemey, Philippe, Karganova, Galina, Postler, Thomas, Bradley J. Blitvich, Beer, Martin, Smith, Donald, Drexler, J. Felix, Imrie, Allison, Jens Bukh, Volker Lohmann, Kuhn, Jens H., Stapleton, Jack, Stapleton, Jack T.   +35 more
core   +1 more source

Eugenol‐Derived Piperazine Mannich Bases as Selective Inhibitors of Mayaro Virus: In Vitro Antiviral Evaluation and Mechanistic Insights

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT Arboviruses represent an ongoing global health challenge, particularly in tropical regions where diseases caused by Chikungunya virus (CHIKV) and Mayaro virus (MAYV) continue to emerge. Given the absence of licensed antiviral therapies, the identification of effective small molecules remains critical.
Adriana Cotta Cardoso Reis, Amália Luíza de Sousa da Silva, Camila Portruneli, Augusto Vieira Pontes Silva, Saulo Fehelberg Pinto Braga, Igor Rodrigues Lapa, Thiago Belarmino de Souza, Lucas Lopardi Franco, Diogo Teixeira Carvalho, Geraldo Célio Brandão   +9 more
wiley   +1 more source

Mapping glycoprotein structure reveals Flaviviridae evolutionary history [PDF]

Viral glycoproteins drive membrane fusion in enveloped viruses and determine host range, tissue tropism and pathogenesis1. Despite their importance, there is a fragmentary understanding of glycoproteins within the Flaviviridae2, a large virus family that
Costa, Vincenzo A., Toon, Kamilla, Mifsud, Jonathon C.O., Lytras, Spyros, Grove, Joe, Oliver, Michael R., Holmes, Edward C.   +6 more
core   +1 more source