Results 81 to 90 of about 40,099 (291)

Potential for Protein Kinase Pharmacological Regulation in Flaviviridae Infections

International Journal of Molecular Sciences, 2020
Protein kinases (PKs) are enzymes that catalyze the transfer of the terminal phosphate group from ATP to a protein acceptor, mainly to serine, threonine, and tyrosine residues.
A. Blázquez, J. Saiz
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Vigilância sorológica para arbovírus em Juruti, Pará, Brasil Serological survey for arboviruses in Juruti, Pará State, Brazil

Cadernos de Saúde Pública, 2009
O objetivo foi avaliar a prevalência de anticorpos para arbovírus na área de influência do Projeto Juruti antes da exploração mineral local. Foram examinados 1.597 soros humanos e 85 de animais silvestres.
Ana Cecilia Ribeiro Cruz, Assis do Socorro Correa dos Prazeres, Eliana Colares Gama, Maxwell Furtado de Lima, Raimunda do Socorro Silva Azevedo, Lívia Medeiros Neves Casseb, Joaquim Pinto Nunes Neto, Lívia Carício Martins, Jannifer Oliveira Chiang, Sueli Guerreiro Rodrigues, Pedro Fernando da Costa Vasconcelos   +10 more
doaj   +1 more source

ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. [PDF]

, 2018
BACKGROUND: Many viruses depend on the extensive membranous network of the endoplasmic reticulum (ER) for their translation, replication, and packaging. Certain membrane modifications of the ER can be a trigger for ER stress, as well as the accumulation ...
Fu, Z, Hu, Q, Ke, X, Li, P, Liu, Y, Sun, J, Tan, Z, Wang, H, Zhang, W, Zhang, Y, Zheng, C, Zheng, Z   +11 more
core   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy [PDF]

, 2018
G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that form within guanine-rich strands of regulatory genomic regions. G4s have been extensively described in the human genome, especially in telomeres and oncogene promoters; in ...
Richter, Sara N, Ruggiero, Emanuela
core   +1 more source

Therapeutic Antibodies for Mosquito‐Borne Orthoflavivirus Infections: Discovery, Engineering Approaches, and Advances in mRNA‐Based Delivery Systems

Advanced Therapeutics, EarlyView.
This review explores how antibody engineering and display technologies are driving therapeutic advances against mosquito‐borne orthoflaviviruses such as Zika, dengue, and yellow fever viruses. It highlights diverse neutralizing targets on the envelope protein, including the conserved fusion loop, and discusses how Fc engineering, rational antigen ...
Ana Clara Barbosa Antonelli, Lucas Silva Rodrigues, Maria Clara Moura Pinheiro, Sylvia Barbosa Pinhate, Marcelo de Macedo Brígido, Andréa Queiroz Maranhão   +5 more
wiley   +1 more source

Zika Virus: A New Chapter in the History of Medicine

Acta Médica Portuguesa, 2016
Keywords: Aedes; Arboviruses; Flavivirus; Flaviviridae Infections.
Carlos Brito
doaj   +1 more source

Host Cell Transcriptome Profile during Wild-Type and Attenuated Dengue Virus Infection [PDF]

, 2013
10.1371/journal.pntd.0002107PLoS Neglected Tropical ...
A Becerra, A Sabchareon, A Wilder-Smith, AJ Matlin, AM Nasirudeen, AM Ward, AW Tai, B Malewicz, B Pulendran, BJ Blencowe, C Balas, C Le Sommer, C Trapnell, C Trapnell, CP Simmons, CS Villas-Boas, CY Huang, CY Yu, D Normile, DJ Gubler, DJ Gubler, DS Deluca, DS Shepard, EJ Nascimento, Eng Eong Ooi, ET Wang, Eva Harris, GF Silveira, HA Tissera, HT Long, HY Huang, I Umareddy, J Fink, J Pena, JA Suaya, JC Marioni, JL Kyle, Kenneth C. Goh, KJ Liew, LR Carrasco, LT Hoang, M Le Breton, MD Fernandez-Garcia, ME Beatty, MJ Schreiber, MM Moreno-Altamirano, MN Krishnan, October M. Sessions, OM Sessions, P Loke, Patrick Tan, Q Li, RV Warke, S Ubol, SB Halstead, Steve Rozen, T Tolfvenstam, TM Conceicao, Y Katz, Ying Tan, Yujing Liu, Z Wang   +61 more
core   +4 more sources

Infection Risk From Humans and Animals in the Anatomy Laboratory: A Scoping Review

Clinical Anatomy, EarlyView.
ABSTRACT Whole‐body dissection is a cornerstone of anatomy education. During and following the COVID‐19 pandemic, exposure to infectious agents and other risks of dissection were highlighted. To identify potential risks, one must have the data outlining these risks in specific situations.
Margaret A. McNulty, Elizabeth R. Agosto
wiley   +1 more source