Results 91 to 100 of about 47,733 (260)

New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity

ChemMedChem, EarlyView.
A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti, Chin Piaw Gwee, Kitti Wing Ki Chan, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Satoru Watanabe, Muhammad Danial Bin Mohd Mazlan, Stefano Sabatini, Serena Massari, Oriana Tabarrini, Gianluca Sbardella, Subhash G. Vasudevan, Giuseppe Manfroni   +13 more
wiley   +1 more source

First report outside Eastern Europe of West Nile virus lineage 2 related to the Volgograd 2007 strain, northeastern Italy, 2014 [PDF]

, 2015
open11noWest Nile virus (WNV) is a Flavivirus transmitted to vertebrate hosts by mosquitoes, maintained in nature through an enzootic bird-mosquito cycle. In Europe the virus became of major public health and veterinary concern in the 1990s.
Elena Porcellato, Fabrizio Montarsi, Francesca Russo, Gioia Capelli, Giovanni Savini, Isabella Monne, Luisa Barzon, Manlio Palei, Silvia Ravagnan, Stefania Cazzin, Stefano Marangon   +10 more
core   +1 more source

Clinical Evaluation of Potential Interaction Between Bemnifosbuvir and Ruzasvir With an Assessment of Food Effect: Results of a Phase 1 Study in Healthy Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A combination of nucleotide hepatitis C virus (HCV) nonstructural protein (NS) 5B and 5A inhibitors is a preferred standard of care for treating chronic HCV. Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against HCV NS5B.
Xiao‐Jian Zhou, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Arantxa Horga, Janet Hammond   +7 more
wiley   +1 more source

New insights into control of arbovirus replication and spread by insect RNA interference pathways [PDF]

, 2012
Arthropod-borne (arbo) viruses are transmitted by vectors, such as mosquitoes, to susceptible vertebrates. Recent research has shown that arbovirus replication and spread in mosquitoes is not passively tolerated but induces host responses to control ...
Andersson, Angelini, Angelini, Arensburger, Arensburger, Attarzadeh-Yazdi, Berry, Blevins, Brackney, Chung, Cirimotich, Cohen, Czech, Ding, Dubrulle, Fagegaltier, Flynt, Franz, Ghildiyal, Henke, Holt, Hussain, Hussain, Iwasaki, Kaminker, Kawamura, Keene, Kwon, Lagos-Quintana, Li, Lim, Lucchetta, Mendes, Morazzani, Mueller, Myles, Nene, Qi, Rezza, Ruby, Saleh, Sanchez-Vargas, Schwarz, Selbach, Sijen, Siu, Skalsky, Tam, Thibault, Vodovar, Watanabe, Waterhouse, Wu, Yan, Zeiner, Zeng   +55 more
core   +3 more sources

Immunological and Safety Considerations When Selecting the Dose Formulation of a Purified Inactivated Zika Virus Vaccine (PIZV)

Microorganisms
We previously reported the first-in-human assessment of three doses (2, 5, and 10 µg) of purified inactivated Zika virus vaccine (PIZV or TAK-426) in the Phase 1 ZIK-101 study (NCT03343626).
Camilo J. Acosta, Francesco Nordio, Eloi Kpamegan, Kelley J. Moss, Pradeep Kumar, Kazuhiro Hirata   +5 more
doaj   +1 more source

Infection order outweighs the role of CD4+ T cells in tertiary flavivirus exposure

iScience, 2022
Summary: The link between CD4+ T and B cells during immune responses to DENV and ZIKV and their roles in cross-protection during heterologous infection is an active area of research.
Nicole Marzan-Rivera, Crisanta Serrano-Collazo, Lorna Cruz, Petraleigh Pantoja, Alexandra Ortiz-Rosa, Teresa Arana, Melween I. Martinez, Armando G. Burgos, Chiara Roman, Loyda B. Mendez, Elizabeth Geerling, Amelia K. Pinto, James D. Brien, Carlos A. Sariol   +13 more
doaj  

Rational design of West Nile virus vaccine through large replacement of 3′ UTR with internal poly(A)

EMBO Molecular Medicine, 2021
The genus Flavivirus comprises numerous emerging and re‐emerging arboviruses causing human illness. Vaccines are the best approach to prevent flavivirus diseases.
Ya‐Nan Zhang, Na Li, Qiu‐Yan Zhang, Jing Liu, Shun‐Li Zhan, Lei Gao, Xiang‐Yue Zeng, Fang Yu, Hong‐Qing Zhang, Xiao‐Dan Li, Cheng‐Lin Deng, Pei‐Yong Shi, Zhi‐Ming Yuan, Shao‐Peng Yuan, Han‐Qing Ye, Bo Zhang   +15 more
doaj   +1 more source

Population, sexual and reproductive health, rights and sustainable development: forging a common agenda. [PDF]

, 2010
This article suggests that sexual and reproductive health and rights activists seeking to influence the post-2015 international development paradigm must work with sustainable development advocates concerned with a range of issues, including climate ...
Campbell, D. M., Carter, P. E., Collins-Emerson, J. M., French, N. P., Hathaway, S., Marshall, J., Midwinter, A. C., Mullner, P., Pirie, R., Shadbolt, T., Spencer, Simon E. F., Wilson, D. J.   +11 more
core   +1 more source

In vivo imaging of Zika virus reveals dynamics of viral invasion in immune-sheltered tissues and vertical propagation during pregnancy [PDF]

, 2020
Rationale: Zika virus (ZIKV) is a pathogenic virus known to cause a wide range of congenital abnormalities, including microcephaly, Guillain-Barre syndrome, meningoencephalitis, and other neurological complications, in humans. This study investigated the
Hu, Q, Ke, X, Li, P, Liu, Y, Luo, D, Miao, Y, Sun, J, Tan, Z, Wang, H, Wang, T, Xu, F, Zhang, Y, Zheng, Z   +12 more
core   +1 more source

Impact of flavivirus vaccine-induced immunity on primary Zika virus antibody response in humans.

PLoS Neglected Tropical Diseases, 2020
BackgroundZika virus has recently spread to South- and Central America, causing congenital birth defects and neurological complications. Many people at risk are flavivirus pre-immune due to prior infections with other flaviviruses (e.g.
Stefan Malafa, Iris Medits, Judith H Aberle, Stephan W Aberle, Denise Haslwanter, Georgios Tsouchnikas, Silke Wölfel, Kristina L Huber, Elena Percivalle, Pascal Cherpillod, Melissa Thaler, Lena Roßbacher, Michael Kundi, Franz X Heinz, Karin Stiasny   +14 more
doaj   +1 more source