Results 101 to 110 of about 45,492 (218)

Chromatin Accessibility Reveals Adaptive Regulatory Variation in a Keystone Freshwater Fish

Molecular Ecology, Volume 35, Issue 18, September 2026.
ABSTRACT Regulatory variation is increasingly recognized as a major driver of adaptive evolution, yet its role in natural populations remains largely unresolved. By integrating ATAC‐seq chromatin profiles with population genomic outlier scans and RNA‐seq gene expression data, we characterize the functional impact of regulatory elements and identify ...
Konrad Taube, Kristina Noreikiene, María‐Eugenia López, Riho Gross, Anti Vasemägi   +4 more
wiley   +1 more source

Ligand‑Based Virtual Screening Discovery of Thienopyrimidinone Derivatives as Allosteric nSMase2 Modulators and Antivirals Against West Nile Virus

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Ligand‐based virtual screening of over five million compounds identifies a thienopyrimidinone hit as a novel allosteric nSMase2 modulator. Structure‐guided optimisation improves inhibitory potency and delivers derivatives with antiviral activity against West Nile virus, expanding the chemical space of nSMase2 inhibitors and supporting host‐directed ...
Hadrián Álvarez‐Fernández, Patricia Mingo‐Casas, Ana‐Belén Blázquez, Flavia Caridi, Miguel A. Martín‐Acebes, María‐Jesús Pérez‐Pérez, Eva‐María Priego   +6 more
wiley   +1 more source

The Challenges of Flavivirus Drug Discovery

, 2011
Many flaviviruses are human pathogens of global importance, but no antiviral medicines are currently available to manage these diseases. Over the past decade, significant progress has been made towards the understanding of flavivirus biology.
Qing-Yin Wang, Pei-Yong Shi, Thomas H. Keller   +2 more
core   +1 more source

Universal primers that amplify RNA from all three flavivirus subgroups [PDF]

, 2008
Background: Species within the Flavivirus genus pose public health problems around the world. Increasing cases of Dengue and Japanese encephalitis virus in Asia, frequent outbreaks of Yellow fever virus in Africa and South America, and the ongoing spread
Gibbs, Mark J., Maher-Sturgess, Sheryl L, Wayper, Paul, Barnard Ross T, Roy A Hall, Naomi L Forrester, Forrester, Naomi L, Paul J Wayper, Wayper, Paul J., Ernest A Gould, Gibbs, Mark, Gould, Ernest A., Hall, Roy A., Gould Ernest A, Barnard, Ross T., Forrester Naomi L, Gould, Ernest A, Forrester, Naomi L., Hall, Roy A, Hall Roy A, Gibbs Mark J, Mark J Gibbs, Maher-Sturgess, Sheryl L., Barnard, Ross T, Wayper Paul J, Sheryl L Maher-Sturgess, Ross T Barnard, Maher-Sturgess Sheryl L   +27 more
core   +1 more source

Evaluating the specificity of flavivirus proteases in Aedes aegypti cells for dengue virus 2-derived cleavage sites.

PLoS ONE
Flaviviruses are a diverse group of RNA viruses known for their significant impact on human health worldwide. We generated a series of reporters that included cleavage sequences from the dengue virus type 2 polyprotein and co-transfected with plasmids ...
Alexius O Dingle, Zach N Adelman
doaj   +1 more source

The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions

, 2018
Autophagy is an evolutionarily conserved cellular process in which intracellular components are eliminated via lysosomal degradation to supply nutrients for organelle biogenesis and metabolic homeostasis.
Po-Yuan Ke
core   +1 more source

Microbial Biotechnology at the Frontiers of Innovation: Engineering Solutions for Health, Industry and Sustainability

Microbial Biotechnology, Volume 19, Issue 9, September 2026.
Patricia Bernal, Juan Luis Ramos
wiley   +1 more source

Are we prepared for emerging flaviviruses in Europe? Challenges for vaccination

Human Vaccines & Immunotherapeutics, 2018
Tick-borne encephalitis and West Nile fever are endemic flavivirus diseases in Europe. Climate change, virus evolution, and social factors may increase the risk of these flavivirus infections and may lead to the emergence of other flaviviruses in Europe ...
Patricia Kaaijk, Willem Luytjes
doaj   +1 more source

Le remodelage morphologique et fonctionnel du cytoplasme par les flavivirus

Les infections par les flavivirus constituent un enjeu de santé publique majeur dans le monde avec dans la plupart des cas aucun traitement antiviral disponible.
Chatel-Chaix, Laurent
core  

Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAs

Nature Communications, 2018
Subgenomic flavivirus RNAs are generated by a host exoribonuclease and play an important role in virus replication and pathogenesis. Here, the authors show the mechanism by which subgenomic flavivirus RNAs are generated and identify two structurally ...
Andrea MacFadden, Zoe O’Donoghue, Patricia A. G. C. Silva, Erich G. Chapman, René C. Olsthoorn, Mark G. Sterken, Gorben P. Pijlman, Peter J. Bredenbeek, Jeffrey S. Kieft   +8 more
doaj   +1 more source