Results 101 to 110 of about 42,662 (220)
Universal primers that amplify RNA from all three flavivirus subgroups [PDF]
Background: Species within the Flavivirus genus pose public health problems around the world. Increasing cases of Dengue and Japanese encephalitis virus in Asia, frequent outbreaks of Yellow fever virus in Africa and South America, and the ongoing spread
Gibbs, Mark J. +27 more
core +1 more source
ABSTRACT A 4‐year‐old boy presented with prolonged fever of unknown origin and systemic inflammation without early neurological signs. MRI revealed multifocal demyelination, and MOG antibodies were positive. He was diagnosed with ADEM and treated with steroids and IVIg, but relapsed twice, consistent with multiphasic disseminated encephalomyelitis ...
Pedro Pau
wiley +1 more source
Notification of the first isolation of Cacipacore virus in a human in the State of Rondônia, Brazil
Flavivirus is a genus of arthropod-transmitted viruses of the family Flaviviridae, and in Brazil, up to eleven different Flavivirus have been isolated. We collected blood from farmers in the municipality of Theobroma, which is located 320km from the City
Weber Cheli Batista +5 more
doaj +1 more source
ProTides for Antiviral Activity Beyond Liver Cells
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel +5 more
wiley +1 more source
Implicações do peptídeo conservado E250-270 da proteína "E" na infectividade do vírus da dengue [PDF]
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia e Biociências, Florianópolis, 2014Os vírus de genoma RNA apresentam uma ampla variabilidade genética, devido à ...
Fleith, Renata Cristina
core
This study elucidates a novel antiviral mechanism of bacterial BEVs, which are shown to inactivate viruses by triggering membrane fusion, subsequent lysis and causing structural collapse. This direct virucidal action presents a promising broad‐spectrum strategy against diverse enveloped viruses.
Yaqi Gao +15 more
wiley +1 more source
Reverse Genetics of Orthoflaviviruses: Strategies for Constructing Functional or Infectious cDNA
ABSTRACT Reverse genetics (RG) systems have transformed RNA virus research by enabling the recovery of recombinant viruses entirely from cloned cDNA. These platforms allow precise, hypothesis‐driven manipulation of viral genomes and support systematic phenotypic analyses in vitro and in vivo.
Young‐Min Lee
wiley +1 more source
Organoids: From Bench to Bedside Applications
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li +6 more
wiley +1 more source
Nomenclature of Flavivirus-Specified Proteins
Flavivirus structural proteins are designated E, C, and M, replacing the former nomenclature of V3 (envelope), V2 (core), and V1 (membrane-like) proteins, respectively. The nonstructural proteins, formerly NV1 through NV5, are designated by their apparent size in kilodaltons, prefixed by P (or GP if a glycoprotein), if they are stable unrelated end ...
E G, Westaway +3 more
openaire +2 more sources
The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions
Autophagy is an evolutionarily conserved cellular process in which intracellular components are eliminated via lysosomal degradation to supply nutrients for organelle biogenesis and metabolic homeostasis.
Po-Yuan Ke
core +1 more source

