Results 11 to 20 of about 15,113 (160)

Molecular Determinants of Tissue Specificity of Flavivirus Nonstructural Protein 1 Interaction with Endothelial Cells

bioRxiv, 2022
Flavivirus NS1 is secreted into the bloodstream from infected cells during a viral infection. Dengue virus NS1 contributes to severe dengue pathology such as endothelial dysfunction and vascular leak independently of the virus.
Nicholas T. N. Lo, Susan Z. Roodsari, Nicole R. Tin, M. Wong, Scott B. Biering, E. Harris   +5 more
semanticscholar   +1 more source

Pathogenesis and virulence of flavivirus infections

Virulence, 2021
The Flavivirus genus consists of >70 members including several that are considered significant human pathogens. Flaviviruses display a broad spectrum of diseases that can be roughly categorised into two phenotypes – systemic disease involving haemorrhage
S. W. van Leur, Tiaan Heunis, D. Munnur, Sumana Sanyal   +3 more
semanticscholar   +1 more source

Molecular Insights into the Flavivirus Replication Complex

Viruses, 2021
Flaviviruses are vector-borne RNA viruses, many of which are clinically relevant human viral pathogens, such as dengue, Zika, Japanese encephalitis, West Nile and yellow fever viruses.
Kaïn van den Elsen, J. Quek, D. Luo
semanticscholar   +1 more source

Implementación de un sistema de detección de flavivirus en mosquitos

Memorias del Instituto de Investigaciones en Ciencias de la Salud, 2021
Los Flavivirus constituyen virus transmitidos por artrópodos, principalmente mosquitos. Pueden producir enfermedades en humanos y animales, también incluyen virus específicos de insectos que solo infectan y se replican en los insectos, no así en ...
Fátima Cardozo, Alejandra Rojas, Cynthia Bernal, Luis Ferreira, Adrián Díaz, Malvina Páez, Yvalena Guillén, Marta Contigiani, Laura Mendoza   +8 more
doaj   +1 more source

Co-Circulation of Two Independent Clades and Persistence of CHIKV-ECSA Genotype during Epidemic Waves in Rio de Janeiro, Southeast Brazil

Pathogens, 2020
The Chikungunya virus infection in Brazil has raised several concerns due to the rapid dissemination of the virus and its association with several clinical complications.
Allison Araújo Fabri, Cintia Damasceno dos Santos Rodrigues, Carolina Cardoso dos Santos, Flávia Löwen Levy Chalhoub, Simone Alves Sampaio, Nieli Rodrigues da Costa Faria, Maria Celeste Torres, Vagner Fonseca, Patricia Brasil, Guilherme Calvet, Luiz Carlos Junior Alcantara, Ana Maria Bispo de Filippis, Marta Giovanetti, Fernanda de Bruycker-Nogueira   +13 more
doaj   +1 more source

Flavivirus Concentrates Host ER in Main Replication Compartments to Facilitate Replication

Advanced Science, 2023
Flavivirus remodels the host endoplasmic reticulum (ER) to generate replication compartments (RCs) as the fundamental structures to accommodate viral replication.
Yali Ci, Kai Han, Jie Kong, Shuhan Huang, Yang Yang, Cheng‐Feng Qin, Lei Shi   +6 more
doaj   +1 more source

Genome-Wide CRISPR Screen Identifies RACK1 as a Critical Host Factor for Flavivirus Replication

Journal of Virology, 2021
Cellular factors are critical in all facets of viral lifecycles, where overlapping interactions between the virus and host can be exploited as possible avenues for the development of antiviral therapeutics.
Byron Shue, Abhilash I. Chiramel, Berati Cerikan, Thu-Hien To, Sonja Frölich, S. Pederson, Emily N Kirby, N. S. Eyre, R. Bartenschlager, S. Best, M. Beard   +10 more
semanticscholar   +1 more source

Two avian Plasmodium species trigger different transcriptional responses on their vector Culex pipiens

Molecular Ecology, EarlyView., 2023
Abstract Malaria is a mosquito‐borne disease caused by protozoans of the genus Plasmodium that affects both humans and wildlife. The fitness consequences of infections by avian malaria are well known in birds, however, little information exists on its impact on mosquitoes.
Marta Garrigós, Guillem Ylla, Josué Martínez‐de la Puente, Jordi Figuerola, María José Ruiz‐López   +4 more
wiley   +1 more source

The structure of an infectious immature flavivirus redefines viral architecture and maturation

Science Advances, 2021
The structure of an infectious immature flavivirus redefines viral architecture and maturation. Flaviviruses are the cause of severe human diseases transmitted by mosquitoes and ticks.
N. Newton, J. Hardy, Naphak Modhiran, L. Hugo, Alberto A. Amarilla, Summa Bibby, H. Venugopal, J. Harrison, Renee J. Traves, R. Hall, J. Hobson-Peters, F. Coulibaly, D. Watterson   +12 more
semanticscholar   +1 more source

Roles of Non-Structural Protein 4A in Flavivirus Infection

Viruses, 2021
Infections with viruses in the genus Flavivirus are a worldwide public health problem. These enveloped, positive sense single stranded RNA viruses use a small complement of only 10 encoded proteins and the RNA genome itself to remodel host cells to ...
Paeka Klaitong, Duncan R. Smith
semanticscholar   +1 more source