Results 41 to 50 of about 15,113 (160)

Flavivirus induces and antagonizes antiviral RNA interference in both mammals and mosquitoes

Science Advances, 2020
Flaviviruses such as dengue use the same strategy to evade RNAi-based intrinsic antiviral defenses in both mammals and mosquitoes. Mosquito-borne flaviviruses infect both mammals and mosquitoes.
Y. Qiu, Yan-Peng Xu, Miao Wang, Meng Miao, Hui-Ying Zhou, Jiuyue Xu, Jing Kong, Da Zheng, Ruiting Li, Rong-Rong Zhang, Yan Guo, Xiao-Feng Li, Jie Cui, C. Qin, Xi Zhou   +14 more
semanticscholar   +1 more source

Mouse Models of Heterologous Flavivirus Immunity: A Role for Cross-Reactive T Cells

Frontiers in Immunology, 2019
Most of the world is at risk of being infected with a flavivirus such as dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, tick-borne encephalitis virus, and Zika virus, significantly impacting millions of lives. Importantly,
Mariah Hassert, James D. Brien, Amelia K. Pinto   +2 more
doaj   +1 more source

In a randomized trial, the live attenuated tetravalent dengue vaccine TV003 is well-tolerated and highly immunogenic in subjects with flavivirus exposure prior to vaccination. [PDF]

PLoS Neglected Tropical Diseases, 2017
Infection caused by the four serotypes of dengue virus (DENV-1-4) is a leading cause of mosquito-borne disease. Clinically-severe dengue disease is more common when secondary dengue infection occurs following prior infection with a heterologous dengue ...
Stephen S Whitehead, Anna P Durbin, Kristen K Pierce, Dan Elwood, Benjamin D McElvany, Ellen A Fraser, Marya P Carmolli, Cecilia M Tibery, Noreen A Hynes, Matthew Jo, Janece M Lovchik, Catherine J Larsson, Elena A Doty, Dorothy M Dickson, Catherine J Luke, Kanta Subbarao, Sean A Diehl, Beth D Kirkpatrick   +17 more
doaj   +1 more source

Flavivirus Envelope Protein Glycosylation: Impacts on Viral Infection and Pathogenesis

Journal of Virology, 2020
Flaviviruses encode one, two, or no N-linked glycosylation sites on their envelope proteins. Glycosylation can impact virus interactions with cell surface attachment factors and also may impact virion stability and virus replication.
Derek L. Carbaugh, Helen M. Lazear
semanticscholar   +1 more source

Detection of novel insect flavivirus sequences integrated in Aedes albopictus (Diptera: Culicidae) in Northern Italy

Virology Journal, 2009
The presence of DNA sequences integrated from a new flavivirus related to Cell Fusing Agent and Kamiti River Virus was identified in wild Aedes albopictus mosquito populations from the provinces of Trentino and Padova, Northern Italy.
Tenorio Antonio, Seco Mari, Vázquez Ana, Roiz David, Rizzoli Annapaola   +4 more
doaj   +1 more source

Molecular characterization of flaviviruses from field-collected mosquitoes in northwestern Italy, 2011–2012

Parasites & Vectors, 2014
Background The genus Flavivirus comprises several mosquito-borne species, including the zoonotic pathogens West Nile and Usutu virus, circulating in animals and humans in Italy since 1998.
Francesca Rizzo, Francesco Cerutti, Marco Ballardini, Andrea Mosca, Nicoletta Vitale, Maria Cristina Radaelli, Rosanna Desiato, Marino Prearo, Alessandra Pautasso, Cristina Casalone, Pierluigi Acutis, Simone Peletto, Maria Lucia Mandola   +12 more
doaj   +1 more source

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

Advanced Theory and Simulations, EarlyView.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak, Shivananda Kandagalla, Ramesh Sistla   +2 more
wiley   +1 more source

DDX3 Regulates the Cap‐Independent Translation of the Japanese Encephalitis Virus via Its Interactions with PABP1 and the Untranslated Regions of the Viral Genome

Advanced Science, EarlyView.
Japanese encephalitis virus (JEV) employs a cap‐independent (CI) translation strategy to evade host translational shutoff. During the shut‐off of host cellular canonical translation, DEAD‐box protein 3 (DDX3) bind to JEV UTRs to establish a closed‐loop architecture, and its interaction with poly(A)‐binding protein 1 (PABP1) to form DDX3/PABP1/eIF4G ...
Chenxi Li, Linjie Zhang, Chenyang Tang, Xuan Chen, Jing Shi, Qingyu Li, Xue Jiao, Jinyao Guo, Bin Wang, Kefan Bu, Abdul Wahaab, Yuguo Yuan, Ming‐an Sun, Yanhua Li   +13 more
wiley   +1 more source

Detection of Zika and dengue viruses in wild-caught mosquitoes collected during field surveillance in an environmental protection area in São Paulo, Brazil.

PLoS ONE, 2020
Species of the genus Flavivirus are widespread in Brazil and are a major public health concern. The country's largest city, São Paulo, is in a highly urbanized area with a few forest fragments which are commonly used for recreation.
Karolina Morales Barrio-Nuevo, Mariana Sequetin Cunha, Adriana Luchs, Aristides Fernandes, Iray Maria Rocco, Luis Filipe Mucci, Renato Pereira de Souza, Antônio Ralph Medeiros-Sousa, Walter Ceretti-Junior, Mauro Toledo Marrelli   +9 more
doaj   +1 more source

Promising Prodiginins Biological Activities

Chemistry &Biodiversity, EarlyView.
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto, Melisa E. Gantner, Boris E. Rodenak‐Kladniew, Santiago Rodriguez, María L. Cuestas, Alan Talevi, Guillermo R. Castro   +6 more
wiley   +1 more source