Results 51 to 60 of about 15,113 (160)
Journal of Virology, 2020 The envelope (E) protein is the dominant target of neutralizing antibodies for dengue virus (DENV) and yellow fever virus (YFV). Accordingly, several DENV vaccine constructs use the E protein in a live attenuated vaccine format, utilizing a backbone ...
A. Grifoni +14 more
semanticscholar +1 more source
New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity
ChemMedChem, EarlyView.A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti +13 more
wiley +1 more source
Protein Post‐Translational Modification‐Mediated Control of Type I Interferon Cascade Signaling
Medicine Bulletin, EarlyView.ABSTRACT Type I interferons (IFN‐Is) constitute the primary defense mechanism against pathogenic infections in the human body. The antiviral signaling mediated by IFN‐I is integral to the host immune response. Nevertheless, an imbalance in IFN‐I function can perturb the organism’s homeostasis. Consequently, it is imperative for the body to meticulously
Xiangjie Chen +3 more
wiley +1 more source
Animals, 2020 Background: A retrospective sero-survey for evidence of West Nile virus (WNV) infection in European wild boar (Sus scorfa) was conducted in the Latium region, Italy, on stored serum samples of the period November 2011 to January 2012.
Angela Petruccelli +6 more
doaj +1 more source
Nature Microbiology, 2018 The endoplasmic reticulum (ER) is an architecturally diverse organelle that serves as a membrane source for the replication of multiple viruses. Flaviviruses, including yellow fever virus, West Nile virus, dengue virus and Zika virus, induce unique ...
R. B. Richardson +11 more
semanticscholar +1 more source
The Antiviral Activity of Polyphenols
Molecular Nutrition &Food Research, EarlyView.Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard +5 more
wiley +1 more source
Journal of the American Chemical Society, 2019 Flaviviruses, including dengue, West Nile and recently emerged Zika virus, are important human pathogens, but there are no drugs to prevent or treat these viral infections.
Yuan Yao +10 more
semanticscholar +1 more source
Advancing dengue vaccine development: Challenges, innovations, and the path toward global protection
Pediatric Investigation, EarlyView.Dengue vaccine development faces challenges, including antibody‐dependent enhancement and serotype‐specific immunity. This review highlights licensed vaccines, CYD‐TDV, TAK‐003, and Butantan‐DV, and explores strategies for achieving effective multivalent protection.
Ran Wang +3 more
wiley +1 more source
Understanding Flavivirus Capsid Protein Functions: The Tip of the Iceberg
Pathogens, 2020 Flaviviruses are enveloped positive-sense single-stranded RNA arboviruses, infectious to humans and many other animals and are transmitted primarily via tick or mosquito vectors.
Stephanea L. Sotcheff, Andrew L. Routh
semanticscholar +1 more source
High‐throughput microfluidic real‐time PCR as a promising tool in disease ecology
Journal of Animal Ecology, EarlyView.This work highlights the diversity of disease ecology questions Htrt PCR could contribute to addressing in a given host–pathogen ecosystem. This tool could be used to answer a broad set of basic and applied questions in animal ecology, notably by providing a way to address issues involving communities of hosts and communities of pathogens.
Tristan Bralet +15 more
wiley +1 more source