Results 131 to 140 of about 40,077 (289)

New insights into control of arbovirus replication and spread by insect RNA interference pathways [PDF]

, 2012
Arthropod-borne (arbo) viruses are transmitted by vectors, such as mosquitoes, to susceptible vertebrates. Recent research has shown that arbovirus replication and spread in mosquitoes is not passively tolerated but induces host responses to control ...
Andersson, Angelini, Angelini, Arensburger, Arensburger, Attarzadeh-Yazdi, Berry, Blevins, Brackney, Chung, Cirimotich, Cohen, Czech, Ding, Dubrulle, Fagegaltier, Flynt, Franz, Ghildiyal, Henke, Holt, Hussain, Hussain, Iwasaki, Kaminker, Kawamura, Keene, Kwon, Lagos-Quintana, Li, Lim, Lucchetta, Mendes, Morazzani, Mueller, Myles, Nene, Qi, Rezza, Ruby, Saleh, Sanchez-Vargas, Schwarz, Selbach, Sijen, Siu, Skalsky, Tam, Thibault, Vodovar, Watanabe, Waterhouse, Wu, Yan, Zeiner, Zeng   +55 more
core   +3 more sources

Sexual transmission of Zika virus and other flaviviruses: A living systematic review

PLoS Medicine, 2018
Background Health authorities in the United States and Europe reported an increasing number of travel-associated episodes of sexual transmission of Zika virus (ZIKV) following the 2015–2017 ZIKV outbreak.
M. Counotte, Caron R Kim, Jingying Wang, K. Bernstein, C. Deal, N. Broutet, N. Low   +6 more
semanticscholar   +1 more source

FDA-Approved Drugs Efavirenz, Tipranavir, and Dasabuvir Inhibit Replication of Multiple Flaviviruses in Vero Cells

Microorganisms, 2020
Vector-borne flaviviruses (VBFs) affect human health worldwide, but no approved drugs are available specifically to treat VBF-associated infections. Here, we performed in silico screening of a library of U.S.
Michal Štefánik, J. Valdés, F. Ezebuo, Jan Haviernik, I. Uzochukwu, Martina Fojtíková, J. Salát, L. Eyer, D. Růžek   +8 more
semanticscholar   +1 more source

Targeted Lymph Node Immunization with Serotype-Specific Dengue VLP Vaccines Enhances Antibody Avidity and Specificity

Vaccines
Introduction: Dengue virus (DENV) remains a global health threat, with four distinct serotypes (DENV1-4) that complicate vaccine development due to low-affinity, cross-reactive antibodies that increase the risk of antibody-dependent enhancement (ADE ...
Dominik A. Rothen, Alessandro Pardini, Sudip Kumar Dutta, Pascal S. Krenger, Anne-Cathrine Vogt, Romano Josi, Monique Vogel, Paul Engeroff, Mona O. Mohsen, Kaspars Tars, Byron Martina, Martin F. Bachmann   +11 more
doaj   +1 more source

Suppression of Type I Interferon Signaling by Flavivirus NS5. [PDF]

, 2018
Type I interferon (IFN-I) is the first line of mammalian host defense against viral infection. To counteract this, the flaviviruses, like other viruses, have encoded a variety of antagonists, and use a multi-layered molecular defense strategy to ...
Hai, Rong, Song, Jikui, Thurmond, Stephanie, Wang, Boxiao   +3 more
core  

Differentiation enhances Zika virus infection of neuronal brain cells. [PDF]

, 2018
Zika virus (ZIKV) is an emerging, mosquito-borne pathogen associated with a widespread 2015-2016 epidemic in the Western Hemisphere and a proven cause of microcephaly and other fetal brain defects in infants born to infected mothers. ZIKV infections have
Bouquet, Jerome, Chiu, Charles Y, Li, Tony, Paranjpe, Aditi, Streithorst, Jessica, Sánchez-San Martín, Claudia, Yu, Guixia   +6 more
core   +3 more sources

Arbidol (Umifenovir): A Broad-Spectrum Antiviral Drug That Inhibits Medically Important Arthropod-Borne Flaviviruses

Viruses, 2018
Arthropod-borne flaviviruses are human pathogens of global medical importance, against which no effective small molecule-based antiviral therapy has currently been reported.
Jan Haviernik, Michal Štefánik, Martina Fojtíková, Sabrina Kali, N. Tordo, I. Rudolf, Z. Hubálek, L. Eyer, D. Růžek   +8 more
semanticscholar   +1 more source

Circulation of zoonotic flaviviruses in wild passerine birds in Western Spain

, 2022
Alfonso Marzal, Martina Ferraguti, Jaime Muriel, Sergio Magallanes, Juan Antonio Ortiz, Luz García‐Longoria, Daniel Bravo‐Barriga, Fátima Guerrero‐Carvajal, Pilar Aguilera‐Sepúlveda, Francisco Rubio Llorente, Florentino de Lope, Miguel Ángel Jiménez‐Clavero, Eva María Frontera Carrión   +12 more
openalex   +1 more source

Flaviviruses of public health concern in South Africa: Present and future threats

Southern African Journal of Infectious Diseases
Background: The resurgence and widespread transmission of flaviviruses over the past few decades are particularly concerning. Aim: This review discusses the structure, aetiology, transmission, detection, diagnosis and prevention strategies for ...
Angela Sibanda-Makuvise, Abigarl Ndudzo, Felicity J. Burt   +2 more
doaj   +1 more source

A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

Nature, 2016
Flaviviruses infect hundreds of millions of people annually, and no antiviral therapy is available. We performed a genome-wide CRISPR/Cas9-based screen to identify host genes that, when edited, resulted in reduced flavivirus infection. Here, we validated
Rong Zhang, Jonathan J. Miner, M. Gorman, Keiko Rausch, H. Ramage, James P. White, Adam Zuiani, Ping Zhang, Estefania Fernandez, Qiang Zhang, Kimberly A. Dowd, T. Pierson, S. Cherry, M. Diamond   +13 more
semanticscholar   +1 more source