Engineered Exosome‐Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia
Exploration, EarlyView.We identified a harmful immune cell type, p21+CD86+ microglia, driving post‐stroke inflammation and developed a targeted exosome‐based therapy (Que@micro‐Exo) to eliminate these cells. This innovative treatment reduced inflammation, alleviated brain damage, and improved recovery in stroke models, offering a promising strategy for stroke and other ...
Jialei Yang, Shipo Wu, Miao He
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Integrated Transcriptomic and Metabolomic Analysis Reveals Tissue-Specific Flavonoid Biosynthesis and MYB-Mediated Regulation of UGT71A1 in <i>Panax quinquefolius</i>. [PDF]
Int J Mol SciWang Y +16 more
europepmc +1 more source
Food Chemistry International, EarlyView.Dark tea undergoes enzymatic oxidation during processing leading to formation of tea metabolites. These compounds may react with amino acids produced from protein breakdown in the digestive tract, that may potentially modulate amino acid availability and influencing metabolic pathways.
Chunlin Li +3 more
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Dietary Flavonoid Intake and Anemia Risk in Children and Adolescents: Insights from National Health and Nutrition Examination Survey. [PDF]
Antioxidants (Basel)Li L, Wang Z, Yu Z, Niu T.
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Application of Bryophytes to Foods, Food Additives and Phytomedicines
Food Chemistry International, EarlyView.Little attention has been paid to the bryophytes for use in the human diet, despite the presence of 23,000 species worldwide. (Marchantia polymorpha). ABSTRACT Little attention has been paid to the bryophytes for application on the human diet, despite the presence of 23,000 species worldwide.
Yoshinori Asakawa, Jianbo Xiao
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Ammoniation of Dietary Flavonoids Containing a Pyrogallol Group With Amino Acids at 37°C
Food Chemistry International, EarlyView.Scheme of reaction exploration, synthesis, structural identification, and bioactivities of ammoniated flavonoids. ABSTRACT New research shows that flavonoids containing a pyrogallol group in ring B react with amino acids at 37°C, forming ammoniated derivatives and aldehydes.
Haolin Zhang +7 more
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Biochemical evaluation of molecular parts for flavonoid production using plant synthetic biology. [PDF]
Front Plant SciLee H, Lee SB, Park S, Song J, Kim BG.
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Food Chemistry International, EarlyView.This minireview highlights that highland barley polyphenols (HBPPs) regulate gut microbiota and promote intestinal homeostasis through antioxidant/anti‐inflammatory activities, barrier reinforcement, and immune modulation, mediated by interactions among HBBPs, intestinal microbiota and intestinal cells.
Yi‐Peng Bai +2 more
wiley +1 more source
Extremely Rare Flavonoid Glycosides Identified in the Stems of <i>Ephedra gerardiana</i> by HPLC-MS and Their Antioxidant Activity. [PDF]
Int J Mol SciSzymborska K +3 more
europepmc +1 more source
Food Frontiers, EarlyView.This study investigated the effect of ferulic acid (FA) on the cold tolerance of banana fruit under 6°C‐storage for 7 days. In comparison with control, 3 mM FA treatment significantly alleviated chilling symptoms of banana fruit by enhancing phenylpropanoid metabolism and maintaining redox and energy homeostasis. ABSTRACT Banana fruit is susceptible to
Yu Hou +9 more
wiley +1 more source