Results 81 to 90 of about 44,095 (208)

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

The FEBS Journal, EarlyView.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna, Christoff Odendaal, Madhulika Singh, Albert Gerding, Miriam Langelaar‐Makkinje, Marianne van der Zwaag, Asmara Drachman, Vladimíra Cetkovská, Gaby Liem Foeng Kioen, Anne‐Claire M. F. Martines, Nicolette C. A. Huijkman, Hein Schepers, Bart van de Sluis, Dirk‐Jan Reijngoud, Ody C. M. Sibon, Amy C. Harms, Thomas Hankemeier, Barbara M. Bakker   +17 more
wiley   +1 more source

Cyanobacterial Oxygenic Photosynthesis is Protected by Flavodiiron Proteins

Life, 2015
Flavodiiron proteins (FDPs, also called flavoproteins, Flvs) are modular enzymes widely present in Bacteria and Archaea. The evolution of cyanobacteria and oxygenic photosynthesis occurred in concert with the modulation of typical bacterial FDPs. Present
Yagut Allahverdiyeva, Janne Isojärvi, Pengpeng Zhang, Eva-Mari Aro   +3 more
doaj   +1 more source

Spectroelectrochemical Elucidation of the Kinetics of Two Closely Spaced Electron Transfers [PDF]

, 2012
The use of spectroelectrochemistry to facilitate the analysis of an EE mechanism was reported in this work. Using a set of spectra as a function of potential, the spectra of all three oxidation states were determined using evolving window factor analysis.
Keesey, Robert L., Ryan, Michael D.
core   +2 more sources

Cinnamic Acid and Sorbic acid Conversion Are Mediated by the Same Transcriptional Regulator in Aspergillus niger

Frontiers in Bioengineering and Biotechnology, 2019
Cinnamic acid is an aromatic compound commonly found in plants and functions as a central intermediate in lignin synthesis. Filamentous fungi are able to degrade cinnamic acid through multiple metabolic pathways.
Ronnie J. M. Lubbers, Adiphol Dilokpimol, Jorge Navarro, Mao Peng, Mei Wang, Anna Lipzen, Vivian Ng, Igor V. Grigoriev, Jaap Visser, Kristiina S. Hildén, Ronald P. de Vries   +10 more
doaj   +1 more source

Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis

Nature Communications, 2021
Helicobacter pylori FabX, a dehydrogenase/isomerase flavoprotein, is required for unsaturated fatty acid synthesis. Here, the authors characterize FabX substrate recognition and catalytic mechanism, and reveal that it contains an atypical [4Fe-4S ...
Jiashen Zhou, Lin Zhang, Liping Zeng, Lu Yu, Yuanyuan Duan, Siqi Shen, Jingyan Hu, Pan Zhang, Wenyan Song, Xiaoxue Ruan, Jing Jiang, Yinan Zhang, Lu Zhou, Jia Jia, Xudong Hang, Changlin Tian, Houwen Lin, Hong-Zhuan Chen, John E. Cronan, Hongkai Bi, Liang Zhang   +20 more
doaj   +1 more source

Reactive oxygen species generated in chloroplasts contribute to tobacco leaf infection by the necrotrophic fungus Botrytis cinerea [PDF]

, 2017
Reactive oxygen species (ROS) play fundamental roles in plant responses to pathogen infection, including modulation of cell death processes and defense-related gene expression.
Bisaro, Fabiana, Carrillo, Nestor Jose, Krapp, Adriana del Rosario, Maiale, Santiago Javier, Pieckenstain, Fernando Luis, Rossi, Franco Rubén   +5 more
core   +1 more source

Unveiling protective mechanisms of wild olive (acebuche) oil in retinal pigment epithelial cells with hypertensive phenotype

The Journal of Physiology, EarlyView.
Abstract figure legend Circulating extracellular vesicles (EVs) derived from acebuche (ACE) oil‐ and extra virgin olive oil (EVOO)‐fed mice modulate nitric oxide (NO) metabolism in the retinal pigment epithelial cell line (ARPE19) with a hypertensive phenotype induced by angiotensin II (AngII).
Álvaro Santana‐Garrido, Claudia Reyes‐Goya, Pablo Espinosa‐Martín, Rosa M. Troya‐Toledo, Helder André, Alfonso Mate, Carmen M. Vázquez   +6 more
wiley   +1 more source

A novel electron transfer flavoprotein dehydrogenase (ETFDH) gene mutation identified in a newborn with glutaric acidemia type II: a case report of a Chinese family

BMC Medical Genetics, 2020
Background Glutaric acidemia type II (GA II) or multiple acyl-CoA dehydrogenase deficiency (MADD, OMIM 231680) is an inherited autosomal recessive disease affecting fatty acid, amino acid and choline metabolism, due to mutations in one of three genes ...
Mingcai Ou, Lin Zhu, Yong Zhang, Yaguo Zhang, Jingyao Zhou, Yu Zhang, Xuelian Chen, Lijuan Yang, Ting Li, Xingyue Su, Qi Hu, Wenjun Wang   +11 more
doaj   +1 more source

Tomographic optical imaging of cortical responses after crossing nerve transfer in mice. [PDF]

PLoS ONE, 2018
To understand the neural mechanisms underlying the therapeutic effects of crossing nerve transfer for brachial plexus injuries in human patients, we investigated the cortical responses after crossing nerve transfer in mice using conventional and ...
Keiichi Maniwa, Haruyoshi Yamashita, Hiroaki Tsukano, Ryuichi Hishida, Naoto Endo, Minoru Shibata, Katsuei Shibuki   +6 more
doaj   +1 more source

Coexistence of Wolbachia with Buchnera aphidicola and a secondary symbiont in the aphid Cinara cedri.

, 2004
Intracellular symbiosis is very common in the insect world. For the aphid Cinara cedri, we have identified by electron microscopy three symbiotic bacteria that can be characterized by their different sizes, morphologies, and electrodensities.
García-Verdugo, José Manuel, Gómez-Valero, Laura, Heddi, Abdelaziz, Latorre, Amparo, Moya, Andrés, Pérez-Brocal, Vicente, Soriano-Navarro, Mario   +6 more
core   +2 more sources