Results 91 to 100 of about 26,547 (202)

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, Volume 293, Issue 15, Page 4624-4644, August 2026.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source

Riboflavin Salvage Supports Glycolysis in Borrelia burgdorferi Through Flavin‐Dependent NAD+ Regeneration

Molecular Microbiology, Volume 126, Issue 2, Page 208-219, August 2026.
The Lyme disease agent Borrelia burgdorferi has limited metabolic capabilities and depends on salvage of riboflavin via the BB0316‐BB0319 transport system for generation of critical flavin cofactors FMN and FAD. Riboflavin is important for NAD+ regeneration to fuel glycolysis.
Anna M. Schulz, Grace E. Easterling, Aaditya Balasubramaniyan, Mollie W. Jewett   +3 more
wiley   +1 more source

The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile

Nature Communications, 2017
The electron-transferring flavoprotein / butyryl-CoA dehydrogenase (EtfAB/Bcd) complex catalyzes the reduction of crotonyl-CoA and ferredoxins by NADH in anaerobic microbes.
Julius K. Demmer, Nilanjan Pal Chowdhury, Thorsten Selmer, Ulrich Ermler, Wolfgang Buckel   +4 more
doaj   +1 more source

Lysine Biosynthesis Defines a Metabolic Checkpoint for Gibberellin‐Mediated Growth in Arabidopsis thaliana

Plant, Cell &Environment, Volume 49, Issue 8, Page 5343-5357, August 2026.
ABSTRACT Lysine represents a metabolic hub linking mitochondrial energy status with amino acid catabolism, yet its role in coordinating plant growth and development remains poorly characterised. The dapat mutant, which is deficient in L,L‐diaminopimelate aminotransferase (DAPAT), exhibits severe growth inhibition associated with broad metabolic ...
Débora Gonçalves Gouveia, Wesley E Bhering Barrios, Auxiliadora Oliveira Martins, João Henrique Cavalcanti, Laíse Rosado‐Souza, João Antonio Siqueira, Danilo de Menezes Daloso, Alisdair R. Fernie, Adriano Nunes‐Nesi, Andreas P. M. Weber, Wagner L. Araújo   +10 more
wiley   +1 more source

Substrate‐specific mitochondrial dysfunction and metabolomic profiles in type 2 diabetic rat hearts

Experimental Physiology, Volume 111, Issue 8, Page 3635-3647, 1 August 2026.
Abstract Type 2 diabetes (T2D) greatly alters cardiac fuel handling, yet how mitochondrial function adapts to the diabetic substrate environment remains unclear. This study investigated substrate‐specific cardiac mitochondrial bioenergetics from a T2D rat model induced by a high‐fat diet and low‐dose streptozotocin.
Toan Pham
wiley   +1 more source

Azurins With Tunable Reduction Potentials as Redox Mediators for Extracellular Electron Transfer

ChemBioChem, Volume 27, Issue 14, 29 July 2026.
Electroactive microbe Shewanella oneidensis reduced non‐native electron transfer protein, azurin, via extracellular electron transfer (EET) with dependence on azurin redox potential. Utilizing azurin in EET‐driven bio‐(electro)catalysis improved fuel cell current and accelerated textile dye decolorization.
Alexis J. Holwerda, Jing‐Xiang Wang, Yang Gao, Yi Lu, Benjamin K. Keitz   +4 more
wiley   +1 more source

Thioredoxin Reductase as a Target for Antibacterial Gold Compounds in Burkholderia cenocepacia: Disclosing the Molecular Basis of Enzyme Inhibition

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
The molecular basis of thioredoxin reductase inhibition by antibacterial gold(I) compounds is disclosed. X‐ray crystallography and high‐resolution ESI‐MS reveal selective gold coordination to catalytically relevant cysteine residues of Bc‐TrxR, leading to stable protein–gold adducts and disruption of enzyme redox activity.
Stefano Zineddu, José Aleixo de Azevedo‐França, Martina Aguanno, Valentina Pecchioli, Giarita Ferraro, Virginia Cuomo, Antonello Merlino, Luigi Messori   +7 more
wiley   +1 more source

Furagin Derivatives—Nitrofuran‐Based Hydrazones as Potential Dual Inhibitors of Thioredoxin Reductase and Carbonic Anhydrases

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Nitrofuran‐based hydrazones derived from furagin are developed as dual inhibitors of thioredoxin reductase 1 and cancer‐associated carbonic anhydrases IX and XII. The series shows selective enzyme inhibition with reduced off‐target carbonic anhydrase (CA) I/II activity, while lead compound 7g exhibits potent TrxR1 inhibition and moderate anticancer ...
Aleksandrs Pustenko, Raitis Bobrovs, Katrīna Freimane, Antons Sizovs, Andrea Angeli, Claudiu T. Supuran, Raivis Žalubovskis   +6 more
wiley   +1 more source

Flavoprotein semiquinone [PDF]

Biochemical Journal, 1972
openaire   +2 more sources

Flavoproteins in Directed Evolution

, 2010
In der vorliegenden Arbeit wurden zwei Enzyme, eine Enoatreduktase (YqjM) und eine Monooxigenase (\(P450_{BM3}\)), mittels "Gerichteter Evolution" auf die Akzeptanz neuer Substrate angepasst. Mittel iterativem CASTing (combinatorial active site saturation test) konnten in beiden Fällen hoch regio- und stereoselektive Mutanten erhalten werden ...
openaire   +2 more sources