Results 81 to 90 of about 29,105 (237)

Discovery and biosynthesis of karnamicins as angiotensin converting enzyme inhibitors

Nature Communications, 2023
Treatment of hypertension entails use of angiotensin-converting enzyme inhibitors. Here, the authors show a series of karnamicins with significant inhibitory activity and identify two unusual flavoprotein hydroxylases involved in the assembly of the ...
Zhiyin Yu, Jian-Ping Huang, Jing Yang, Chongxi Liu, Yijun Yan, Li Wang, Junwei Zhao, Yin Chen, Wensheng Xiang, Sheng-Xiong Huang   +9 more
doaj   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Molecularly Engineered 2D Xene Heterostructures With Implanted Peroxidase‐Like Activity for Mimicking Enzyme Functions

Small Methods, EarlyView.
A modular electropolymerization strategy is used to covalently graft a vinyl‐terminated Co(II) molecular catalyst onto allyl 2D germanane. This molecular programming approach yields a 2D Xene nanozyme with implanted peroxidase‐like activity, enabling sensitive and selective electrochemical detection of hydrogen peroxide and the monitoring of ...
Yiming Lei, Xavier Sala, Jordi García‐Antón, Jose Muñoz   +3 more
wiley   +1 more source

Cyanobacterial Oxygenic Photosynthesis is Protected by Flavodiiron Proteins

Life, 2015
Flavodiiron proteins (FDPs, also called flavoproteins, Flvs) are modular enzymes widely present in Bacteria and Archaea. The evolution of cyanobacteria and oxygenic photosynthesis occurred in concert with the modulation of typical bacterial FDPs. Present
Yagut Allahverdiyeva, Janne Isojärvi, Pengpeng Zhang, Eva-Mari Aro   +3 more
doaj   +1 more source

StyA1 and StyA2B from Rhodococcus opacus 1CP: a Multifunctional Styrene Monooxygenase System

, 2010
Two-component flavoprotein monooxygenases are emerging biocatalysts that generally consist of a monooxygenase and a reductase component. Here we show that Rhodococcus opacus 1CP encodes a multifunctional enantioselective flavoprotein monooxygenase system
Groning, J.A.D., Michael Schlömann, Kaschabek, S.R., Dirk Tischler, Stefan R. Kaschabek, van Berkel, W.J.H., Tischler, D., Berkel, W.J.H., van, Willem J. H. van Berkel, René Kermer, Janosch A. D. Gröning, Schlomann, M., Kermer, R.   +12 more
core   +1 more source

Recent Advances in Photocatalyst‐Driven Protein Labeling and Proximity Mapping

The Chemical Record, EarlyView.
Photocatalyst‐driven protein labeling and proximity mapping have rapidly advanced as powerful strategies for spatiotemporal control in complex biological environments. This review integrates recent developments across single‐electron transfer and energy transfer‐based mechanisms and highlights how catalyst design, reactive intermediates, and diffusion ...
Shinichi Sato, Kazuki Miura, Juki Nakao, Hiroyuki Nakamura   +3 more
wiley   +1 more source

Cinnamic Acid and Sorbic acid Conversion Are Mediated by the Same Transcriptional Regulator in Aspergillus niger

Frontiers in Bioengineering and Biotechnology, 2019
Cinnamic acid is an aromatic compound commonly found in plants and functions as a central intermediate in lignin synthesis. Filamentous fungi are able to degrade cinnamic acid through multiple metabolic pathways.
Ronnie J. M. Lubbers, Adiphol Dilokpimol, Jorge Navarro, Mao Peng, Mei Wang, Anna Lipzen, Vivian Ng, Igor V. Grigoriev, Jaap Visser, Kristiina S. Hildén, Ronald P. de Vries   +10 more
doaj   +1 more source

A novel electron transfer flavoprotein dehydrogenase (ETFDH) gene mutation identified in a newborn with glutaric acidemia type II: a case report of a Chinese family

BMC Medical Genetics, 2020
Background Glutaric acidemia type II (GA II) or multiple acyl-CoA dehydrogenase deficiency (MADD, OMIM 231680) is an inherited autosomal recessive disease affecting fatty acid, amino acid and choline metabolism, due to mutations in one of three genes ...
Mingcai Ou, Lin Zhu, Yong Zhang, Yaguo Zhang, Jingyao Zhou, Yu Zhang, Xuelian Chen, Lijuan Yang, Ting Li, Xingyue Su, Qi Hu, Wenjun Wang   +11 more
doaj   +1 more source

Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis

Nature Communications, 2021
Helicobacter pylori FabX, a dehydrogenase/isomerase flavoprotein, is required for unsaturated fatty acid synthesis. Here, the authors characterize FabX substrate recognition and catalytic mechanism, and reveal that it contains an atypical [4Fe-4S ...
Jiashen Zhou, Lin Zhang, Liping Zeng, Lu Yu, Yuanyuan Duan, Siqi Shen, Jingyan Hu, Pan Zhang, Wenyan Song, Xiaoxue Ruan, Jing Jiang, Yinan Zhang, Lu Zhou, Jia Jia, Xudong Hang, Changlin Tian, Houwen Lin, Hong-Zhuan Chen, John E. Cronan, Hongkai Bi, Liang Zhang   +20 more
doaj   +1 more source

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, EarlyView.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source