Results 71 to 80 of about 14,439 (221)

Fluconazole induces ROS in Cryptococcus neoformans and contributes to DNA damage in vitro.

PLoS ONE, 2018
Pathogenic basidiomycetous yeast, Cryptococcus neoformans, causes fatal meningitis in immunocompromised individuals. Fluconazole (FLC) is a fungistatic drug commonly administered to treat cryptococcosis. Unfortunately, FLC-resistant strains characterized
Congyue Annie Peng, Andrea A E Gaertner, Sarah Ana Henriquez, Diana Fang, Rodney J Colon-Reyes, Julia L Brumaghim, Lukasz Kozubowski   +6 more
doaj   +1 more source

Desfechos e instrumentos padronizados utilizados em intervenções fisioterapêuticas via telessaúde para crianças com paralisia cerebral: uma revisão de escopo usando a CIF

Developmental Medicine &Child Neurology, EarlyView.
CIF: Classificação Internacional de Funcionalidade, Incapacidade e Saúde. Resumo Objetivo Identificar os desfechos e instrumentos padronizados utilizados para medir mudanças após intervenções fisioterapêuticas realizadas via telessaúde em crianças e jovens com paralisia cerebral, de acordo com os domínios da Classificação Internacional de ...
Isabella S Christovão, Paula S de C Chagas, Ana Alice V Aniceto, Daiane A de O Bettoni, Lorena C Ferreira, Hércules R Leite, Ana Cristina R Camargos   +6 more
wiley   +1 more source

Light Chain Monoclonal Gammopathy of Undetermined Significance: Diagnosis, Biology, and Clinical Management

European Journal of Haematology, EarlyView.
ABSTRACT Light chain monoclonal gammopathy of undetermined significance (LC‐MGUS) is defined by an abnormal serum free light chain ratio and elevated involved light chain in the absence of a detectable immunoglobulin heavy chain on immunofixation and of end‐organ damage attributable to a plasma cell disorder.
Sigurður Yngvi Kristinsson, Thórir Einarsson Long, Sigrún Thorsteinsdóttir   +2 more
wiley   +1 more source

Increase of reactive oxygen species contributes to growth inhibition by fluconazole in Cryptococcus neoformans

BMC Microbiology, 2019
Background Cryptococcus neoformans, a basidiomycetous yeast, is a fungal pathogen that can colonize the lungs of humans causing pneumonia and fungal meningitis in severely immunocompromised individuals.
Nadir Hani Dbouk, Madison Bailey Covington, Kenny Nguyen, Srikripa Chandrasekaran   +3 more
doaj   +1 more source

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome‐linked mutations

The FEBS Journal, EarlyView.
Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano, Alessandra Bigi, Francesca Troilo, Federica Gabriele, Gianluca Pistoia, Italia A. Asteriti, Francesco Angelucci, Giorgio Giardina, Fabrizio Chiti, Carlo Travaglini‐Allocatelli, Adele Di Matteo   +10 more
wiley   +1 more source

ZnO1−xSx Nanosphere in Ferroelectric Liquid Crystal Matrix: The Effect of Aggregation and Defects on the Dielectric and Electro-Optical Properties

Advances in Condensed Matter Physics, 2013
High concentration (5 wt %) of ZnO1−xSx nanosphere (NS) has been dispersed in the ferroelectric liquid crystal (FLC) to analyze the effect of high dopant concentration in the FLC matrix. The FLC molecules actively interact with the NS. The presence of NS
Dharmendra Pratap Singh, Swadesh Kumar Gupta, Rajiv Manohar   +2 more
doaj   +1 more source

Filter feeders living on suspension feeders: New insights into the lifestyle and distribution of Arcturidae Dana, 1849 (Crustacea: Isopoda) around Iceland

Marine Ecology, EarlyView.
Abstract The focus of the present study was on arcturid isopods occurring in the subarctic region around Iceland. Data from two decades of sampling with an epibenthic sledge (EBS) during numerous expeditions of the BIOICE (Benthic Invertebrates of Icelandic Waters; 1992–2004) and IceAGE (Icelandic marine Animals: Genetics and Ecology; 2011—ongoing ...
Vivien Lukas Hartmann, Emanuel Pereira, Nancy F. Mercado‐Salas, Anne‐Nina Lörz, Jörundur Svavarsson, Saskia Brix   +5 more
wiley   +1 more source

Searching for safety: Working conditions and policing in a US emergency department

Medical Anthropology Quarterly, EarlyView.
Abstract In the United States, emergency departments aren't supposed to turn anyone away. They are the safety‐net of the safety‐net providing life‐saving care. Yet, what happens to healthcare when conditions are so strained that patients and staff lash out at each other? What happens when the safety net becomes a carceral net?
Fabián Luis C. Fernández
wiley   +1 more source

The roads most traveled: genetic convergence in plant repeated evolution

New Phytologist, EarlyView.
Observation of a genotype–phenotype association in a focal lineage (magnifying lens) provides a starting point for predicting homolog reuse during repeated trait evolution. This review suggests that the likelihood that mutations in homologous genes contribute to similar phenotypes in other lineages depends on both mutational effect stability (MES) and ...
James W. Satterlee
wiley   +1 more source

Adaptive Optical Interconnect Using an FLC SLM

Ferroelectrics, 2004
Optical interconnects between boards are becoming more and more important as the data rate in electronic systems increases into the GHz regions. One way of avoiding data bottlenecks in board to board interconnects is to use optical links to transmit the data.
Wilkinson, T, Henderson, C, Leyva, D, Robertson, B, O'Brien, D, Faulkner, G   +5 more
openaire   +2 more sources