Results 1 to 10 of about 5,632 (146)

Identification and Characterization of Mediators of Fluconazole Tolerance in Candida albicans [PDF]

Frontiers in Microbiology, 2020
Candida albicans is an important human pathogen and a major concern in intensive care units around the world. C. albicans infections are associated with a high mortality despite the use of antifungal treatments.
Eric Delarze, Ludivine Brandt, Emilie Trachsel, Marion Patxot, Claire Pralong, Fabio Maranzano, Murielle Chauvel, Mélanie Legrand, Sadri Znaidi, Marie-Elisabeth Bougnoux, Marie-Elisabeth Bougnoux, Marie-Elisabeth Bougnoux, Christophe d’Enfert, Dominique Sanglard   +13 more
doaj   +10 more sources

Uncovering the connection between tunicamycin-induced respiratory deficiency and reduced fluconazole tolerance in Candida glabrata [PDF]

Frontiers in Microbiology
IntroductionCandida glabrata is a prevalent opportunistic fungal pathogen in humans, and fluconazole (FLC) is one of the most commonly used antifungal agents. However, the molecular mechanisms underlying FLC tolerance in C.
Lijun Zheng, Yubo Dong, Jing Wang, Maoji Zhang, Yi Xu, Linfeng Ma, Liangsheng Guo   +6 more
doaj   +6 more sources

Fluconazole tolerance and virulence adaptations of Candida albicans isolated from head and neck cancer patients [PDF]

Journal of Oral Microbiology
Background Candida albicans is the predominant opportunistic pathogen causing oral candidiasis in immunocompromised head and neck cancer (HNC) patients.
Phimchat Suwannaphong, Patcharin Thammasit, Artid Amsri, Waranyu Ueangphairot, Pooriwat Muangwong, Kittikun Kittidachanan, Imjai Chitapanarux, Jiraporn Kantapan, Nathupakorn Dechsupa, Sirida Youngchim   +9 more
doaj   +6 more sources

Low Glucose Mediated Fluconazole Tolerance in Cryptococcus neoformans [PDF]

Journal of Fungi, 2021
Chronic meningoencephalitis is caused by Cryptococcus neoformans and is treated in many parts of the world with fluconazole (FLC) monotherapy, which is associated with treatment failure and poor outcome. In the host, C.
Somanon Bhattacharya, Natalia Kronbauer Oliveira, Anne G. Savitt, Vanessa K. A. Silva, Rachel B. Krausert, Berhane Ghebrehiwet, Bettina C. Fries   +6 more
doaj   +5 more sources

Parallel evolution of fluconazole resistance and tolerance in Candida glabrata

Frontiers in Cellular and Infection Microbiology
IntroductionWith the growing population of immunocompromised individuals, opportunistic fungal pathogens pose a global health threat. Candida species, particularly C. albicans and non-albicans Candida species such as C.
Lijun Zheng, Yi Xu, Chen Wang, Yubo Dong, Liangsheng Guo   +4 more
doaj   +5 more sources

Requirement for Ergosterol in Berberine Tolerance Underlies Synergism of Fluconazole and Berberine against Fluconazole-Resistant Candida albicans Isolates [PDF]

Frontiers in Cellular and Infection Microbiology, 2017
Candida albicans is one of the most common fungal pathogens. Our previous study demonstrated that concomitant use of berberine (BBR) and fluconazole (FLC) showed a synergistic action against FLC-resistant C.
Yi Xu, Hua Quan, Hua Quan, Yan Wang, Hua Zhong, Jun Sun, Jianjiang Xu, Nuan Jia, Yuanying Jiang   +8 more
doaj   +5 more sources

Fluconazole tolerance is associated with altered extracellular vesicle-mediated epithelial immune responses in Candida albicans [PDF]

Frontiers in Microbiology
Candida albicans is a major opportunistic fungal pathogen and a leading cause of oropharyngeal candidiasis, particularly in immunocompromised individuals.
Patcharin Thammasit, Artid Amsri, Artid Amsri, Phimchat Suwannaphong, Yuanji Teng, Yuanji Teng, Huamei Wei, Huamei Wei, Sirida Youngchim   +8 more
doaj   +3 more sources

Comprehensive profiling of lysine lactylation in Candida albicans and exploratory analysis of fluconazole tolerance associations [PDF]

Microbiology Spectrum
Candida albicans is the primary pathogen of invasive candidiasis in most regions worldwide, but the therapy options for C. albicans infections are limited, and drug tolerance further exacerbates the treatment challenges.
Yuying Huang, Nana Song, Danrui Jing, Weida Liu, Dongmei Li, Xiaowei Zhou, Xiaofang Li   +6 more
doaj   +4 more sources

Understanding adaptation to fluconazole: comparative insights into tolerance and resistance in Saccharomyces cerevisiae and Candida albicans

Frontiers in Cellular and Infection Microbiology
IntroductionAntifungal resistance and tolerance are distinct responses exhibited by fungi when exposed to drugs. While considerable research has focused on azole tolerance in the human pathogen Candida albicans, studies in other fungal species remain ...
Lijun Zheng, Yubo Dong, Jing Wang, Yonghui Jia, Weifang Wang, Yi Xu, Yi Xu, Liangsheng Guo   +7 more
doaj   +5 more sources

Understanding fluconazole tolerance in Candida albicans: implications for effective treatment of candidiasis and combating invasive fungal infections

Journal of Global Antimicrobial Resistance, 2023
: Objectives: Fluconazole (FLC) tolerant phenotypes in Candida species contribute to persistent candidemia and the emergence of FLC resistance. Therefore, making FLC fungicidal and eliminating FLC tolerance are important for treating invasive fungal ...
Yanru Feng, Hui Lu, Malcolm Whiteway, Yuanying Jiang   +3 more
doaj   +5 more sources