Results 1 to 10 of about 5,805 (121)

Uncovering the connection between tunicamycin-induced respiratory deficiency and reduced fluconazole tolerance in Candida glabrata [PDF]

Frontiers in Microbiology
IntroductionCandida glabrata is a prevalent opportunistic fungal pathogen in humans, and fluconazole (FLC) is one of the most commonly used antifungal agents. However, the molecular mechanisms underlying FLC tolerance in C.
Yubo Dong
exaly   +4 more sources

Identification and Characterization of Mediators of Fluconazole Tolerance in Candida albicans [PDF]

Frontiers in Microbiology, 2020
Candida albicans is an important human pathogen and a major concern in intensive care units around the world. C. albicans infections are associated with a high mortality despite the use of antifungal treatments.
Sadri Znaidi, Dominique Sanglard, Melanie Legrand   +2 more
exaly   +4 more sources

Fluconazole tolerance and virulence adaptations of Candida albicans isolated from head and neck cancer patients [PDF]

Journal of Oral Microbiology
Background Candida albicans is the predominant opportunistic pathogen causing oral candidiasis in immunocompromised head and neck cancer (HNC) patients.
Sirida Youngchim, Nathupakorn Dechsupa, Pooriwat Muangwong   +2 more
exaly   +4 more sources

Low Glucose Mediated Fluconazole Tolerance in Cryptococcus neoformans [PDF]

Journal of Fungi, 2021
Chronic meningoencephalitis is caused by Cryptococcus neoformans and is treated in many parts of the world with fluconazole (FLC) monotherapy, which is associated with treatment failure and poor outcome. In the host, C.
Somanon Bhattacharya, Natalia Kronbauer Oliveira, Anne G. Savitt, Vanessa K. A. Silva, Rachel B. Krausert, Berhane Ghebrehiwet, Bettina C. Fries   +6 more
doaj   +2 more sources

A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols.

MBio, 2023
Fluconazole (FLC) is widely used to prevent and treat invasive fungal infections. However, FLC is a fungistatic agent, allowing clinical FLC-susceptible isolates to tolerate FLC. Making FLC fungicidal in combination with adjuvants is a promising strategy
Hui Lu, Wanqian Li, Hongkang Wang
exaly   +3 more sources

Fluconazole tolerance is associated with altered extracellular vesicle-mediated epithelial immune responses in Candida albicans [PDF]

Frontiers in Microbiology
Candida albicans is a major opportunistic fungal pathogen and a leading cause of oropharyngeal candidiasis, particularly in immunocompromised individuals.
Patcharin Thammasit, Artid Amsri, Artid Amsri, Phimchat Suwannaphong, Yuanji Teng, Yuanji Teng, Huamei Wei, Huamei Wei, Sirida Youngchim   +8 more
doaj   +2 more sources

ER stress selects for Candida auris survivors with acquired fluconazole resistance and caspofungin tolerance [PDF]

Frontiers in Microbiology
Exposure to endoplasmic reticulum (ER) stress can drive the emergence of antifungal resistance in pathogenic fungi, but the underlying mechanisms remain poorly understood.
Feng Yang, Liuliu Sun, Hao Li, Ting Fang, Qinli Guo, Nan Chen, Yuanying Jiang   +6 more
doaj   +2 more sources

In vitro exposure to the agricultural triazole tebuconazole selects for fluconazole cross−resistance and echinocandin tolerance in Candidozyma auris [PDF]

Frontiers in Cellular and Infection Microbiology
The agricultural triazole fungicide tebuconazole (TCZ) has been implicated in the emergence of azole resistance in human fungal pathogens, but its direct role in selecting resistance and tolerance in Candidozyma auris remains unclear.
Lihao Peng, Yi Xu, Xinyi Chen, Wenhui Li, Liangsheng Guo   +4 more
doaj   +2 more sources

Comprehensive profiling of lysine lactylation in Candida albicans and exploratory analysis of fluconazole tolerance associations [PDF]

Microbiology Spectrum
Candida albicans is the primary pathogen of invasive candidiasis in most regions worldwide, but the therapy options for C. albicans infections are limited, and drug tolerance further exacerbates the treatment challenges.
Yuying Huang, Nana Song, Danrui Jing, Weida Liu, Dongmei Li, Xiaowei Zhou, Xiaofang Li   +6 more
doaj   +2 more sources

Understanding adaptation to fluconazole: comparative insights into tolerance and resistance in Saccharomyces cerevisiae and Candida albicans

Frontiers in Cellular and Infection Microbiology
IntroductionAntifungal resistance and tolerance are distinct responses exhibited by fungi when exposed to drugs. While considerable research has focused on azole tolerance in the human pathogen Candida albicans, studies in other fungal species remain ...
Yubo Dong
exaly   +3 more sources