Results 1 to 10 of about 5,569 (123)

Identification and Characterization of Mediators of Fluconazole Tolerance in Candida albicans [PDF]

Frontiers in Microbiology, 2020
Candida albicans is an important human pathogen and a major concern in intensive care units around the world. C. albicans infections are associated with a high mortality despite the use of antifungal treatments.
Eric Delarze, Ludivine Brandt, Emilie Trachsel, Marion Patxot, Claire Pralong, Fabio Maranzano, Murielle Chauvel, Mélanie Legrand, Sadri Znaidi, Marie-Elisabeth Bougnoux, Marie-Elisabeth Bougnoux, Marie-Elisabeth Bougnoux, Christophe d’Enfert, Dominique Sanglard   +13 more
doaj   +4 more sources

Fluconazole tolerance and virulence adaptations of Candida albicans isolated from head and neck cancer patients [PDF]

Journal of Oral Microbiology
Background Candida albicans is the predominant opportunistic pathogen causing oral candidiasis in immunocompromised head and neck cancer (HNC) patients.
Phimchat Suwannaphong, Patcharin Thammasit, Artid Amsri, Waranyu Ueangphairot, Pooriwat Muangwong, Kittikun Kittidachanan, Imjai Chitapanarux, Jiraporn Kantapan, Nathupakorn Dechsupa, Sirida Youngchim   +9 more
doaj   +4 more sources

Low Glucose Mediated Fluconazole Tolerance in Cryptococcus neoformans [PDF]

Journal of Fungi, 2021
Chronic meningoencephalitis is caused by Cryptococcus neoformans and is treated in many parts of the world with fluconazole (FLC) monotherapy, which is associated with treatment failure and poor outcome. In the host, C.
Somanon Bhattacharya, Natalia Kronbauer Oliveira, Anne G. Savitt, Vanessa K. A. Silva, Rachel B. Krausert, Berhane Ghebrehiwet, Bettina C. Fries   +6 more
doaj   +2 more sources

Fluconazole tolerance is associated with altered extracellular vesicle-mediated epithelial immune responses in Candida albicans [PDF]

Frontiers in Microbiology
Candida albicans is a major opportunistic fungal pathogen and a leading cause of oropharyngeal candidiasis, particularly in immunocompromised individuals.
Patcharin Thammasit, Artid Amsri, Artid Amsri, Phimchat Suwannaphong, Yuanji Teng, Yuanji Teng, Huamei Wei, Huamei Wei, Sirida Youngchim   +8 more
doaj   +2 more sources

Uncovering the connection between tunicamycin-induced respiratory deficiency and reduced fluconazole tolerance in Candida glabrata [PDF]

Frontiers in Microbiology
IntroductionCandida glabrata is a prevalent opportunistic fungal pathogen in humans, and fluconazole (FLC) is one of the most commonly used antifungal agents. However, the molecular mechanisms underlying FLC tolerance in C.
Lijun Zheng, Yubo Dong, Jing Wang, Maoji Zhang, Yi Xu, Linfeng Ma, Liangsheng Guo   +6 more
doaj   +2 more sources

A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols

mBio, 2023
Fluconazole (FLC) is widely used to prevent and treat invasive fungal infections. However, FLC is a fungistatic agent, allowing clinical FLC-susceptible isolates to tolerate FLC. Making FLC fungicidal in combination with adjuvants is a promising strategy
Hui Lu, Wanqian Li, Malcolm Whiteway, Hongkang Wang, Shuo Zhu, Zhe Ji, Yanru Feng, Lan Yan, Ting Fang, Liping Li, Tingjunhong Ni, Xiaolong Zhang, Quanzhen Lv, Zichao Ding, Lijuan Qiu, Dazhi Zhang, Yuanying Jiang   +16 more
doaj   +3 more sources

Understanding fluconazole tolerance in Candida albicans: implications for effective treatment of candidiasis and combating invasive fungal infections

Journal of Global Antimicrobial Resistance, 2023
: Objectives: Fluconazole (FLC) tolerant phenotypes in Candida species contribute to persistent candidemia and the emergence of FLC resistance. Therefore, making FLC fungicidal and eliminating FLC tolerance are important for treating invasive fungal ...
Yanru Feng, Hui Lu, Malcolm Whiteway, Yuanying Jiang   +3 more
doaj   +3 more sources

Gim3 buffers and potentiates de novo mutations that affect fluconazole susceptibility in yeast [PDF]

EMBO Reports
Gim3 is an evolutionarily conserved component of the prefoldin chaperone complex, involved in protein folding. We previously found that GIM3 genetically interacts with many de novo mutations in Saccharomyces cerevisiae.
Mohammed T Tawfeeq, Dimitrios Konstantinidis, Ana Lucia Rocha Iraizos, Wouter Van Genechten, Jolien Vreys, Lieselotte Vermeersch, Karin Voordeckers, Patrick Van Dijck, Kevin J Verstrepen   +8 more
doaj   +2 more sources

Comprehensive profiling of lysine lactylation in Candida albicans and exploratory analysis of fluconazole tolerance associations [PDF]

Microbiology Spectrum
Candida albicans is the primary pathogen of invasive candidiasis in most regions worldwide, but the therapy options for C. albicans infections are limited, and drug tolerance further exacerbates the treatment challenges.
Yuying Huang, Nana Song, Danrui Jing, Weida Liu, Dongmei Li, Xiaowei Zhou, Xiaofang Li   +6 more
doaj   +2 more sources

With age comes resilience: how mitochondrial modulation drives age-associated fluconazole tolerance in Cryptococcus neoformans [PDF]

mBio
Cryptococcus neoformans (Cn) is an opportunistic fungal microorganism that causes life-threatening meningoencephalitis. During the infection, the microbial population is heterogeneously composed of cells with varying generational ages, with older cells ...
Kyungyoon Yoo, Somanon Bhattacharya, Natalia Kronbauer Oliveira, Nivea Pereira de Sa, Gabriel Soares Matos, Maurizio Del Poeta, Bettina C. Fries   +6 more
doaj   +2 more sources