Emerging Microbes and Infections, 2022 Patients presenting with severe COVID-19 are predisposed to acquire secondary fungal infections such as COVID-19-associated candidemia (CAC), which are associated with poor clinical outcomes despite antifungal treatment.
Farnaz Daneshnia +11 more
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Frontiers in Cellular and Infection MicrobiologyIntroductionAntifungal resistance and tolerance are distinct responses exhibited by fungi when exposed to drugs. While considerable research has focused on azole tolerance in the human pathogen Candida albicans, studies in other fungal species remain ...
Lijun Zheng +7 more
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Vacuolar iron export alters the synergy between doxycycline and fluconazole by affecting cidal ROS levels in Candida albicans [PDF]
mBioFungal infections are combatted using three main classes of antifungals, of which the azoles, considered to be fungistatic, are the most widely used. Slow growth of Candida albicans at supra-minimal inhibitory concentrations (MIC) of fluconazole (FLC ...
Wouter Van Genechten +5 more
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Enhanced Tolerance to Antifungals as a General Feature of Rho− Mutants in Yeast Species: Implications to Positive Selection of Respiratory Deficiency [PDF]
MicroorganismsAlthough the mitochondrial genome is an attribute of all eukaryotes, some yeast species (called petite-positive) can replicate without mitochondrial DNA (mtDNA).
Zachary Johnson +2 more
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Candida bracarensis: Evaluation of virulence factors and its tolerance to Amphotericin B and Fluconazole [PDF]
Mycopathologia, 2015 Candida bracarensis is an uncommon Candida species found during an epidemiological study of candidiasis performed in Braga, Portugal. Initially, it was identified as C. glabrata, but recently detailed analyses pointed out their differences.
Moreira, A. +5 more
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Investigation of the relationship between fluconazole susceptibility, proteinase activity and ERG11-SAP2 Expression in Candida albicans strains isolated from clinical samples [PDF]
Current Medical MycologyBackground and Purpose: Candida albicans is currently recognised as an opportunistic pathogen that can cause many invasive infections. Resistance mechanisms and fungal virulence factors play an important role in the effectiveness of treatment. The aim of
Nagihan Ege +4 more
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Frontiers in Microbiology, 2020 Candida albicans causes life-threatening systemic infections in immunosuppressed patients. These infections are commonly treated with fluconazole, an antifungal agent targeting the ergosterol biosynthesis pathway.
Margot Delavy +6 more
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Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence. [PDF]
PLoS Pathogens, 2010 Candida albicans, the major fungal pathogen of humans, causes life-threatening infections in immunocompromised individuals. Due to limited available therapy options, this can frequently lead to therapy failure and emergence of drug resistance. To improve
Elias Epp +10 more
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PLoS ONE, 2023 Candida albicans is a commensal yeast that has important impacts on host metabolism and immune function, and can establish life-threatening infections in immunocompromised individuals. Previously, C.
Andrew W Day, Carol A Kumamoto
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Candida albicans Genotyping and Relationship of Virulence Factors with Fluconazole Tolerance in Infected Pediatric Patients. [PDF]
Infect Drug Resist, 2022 Candida albicans of different genotypes is a common cause of fungal infection in pediatric setting. This cross sectional study was designed to investigate ABC genotypes and the relationship between virulence factors and fluconazole tolerance among C. albicans isolates from infected pediatric patients.C.
Mashaly GE, Zeid MS.
europepmc +3 more sources