Vacuolar iron export alters the synergy between doxycycline and fluconazole by affecting cidal ROS levels in Candida albicans [PDF]
mBioFungal infections are combatted using three main classes of antifungals, of which the azoles, considered to be fungistatic, are the most widely used. Slow growth of Candida albicans at supra-minimal inhibitory concentrations (MIC) of fluconazole (FLC ...
Wouter Van Genechten +5 more
doaj +2 more sources
PLoS ONE, 2023 Candida albicans is a commensal yeast that has important impacts on host metabolism and immune function, and can establish life-threatening infections in immunocompromised individuals. Previously, C.
Andrew W Day, Carol A Kumamoto
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Candida albicans Genotyping and Relationship of Virulence Factors with Fluconazole Tolerance in Infected Pediatric Patients. [PDF]
Infect Drug Resist, 2022 Candida albicans of different genotypes is a common cause of fungal infection in pediatric setting. This cross sectional study was designed to investigate ABC genotypes and the relationship between virulence factors and fluconazole tolerance among C. albicans isolates from infected pediatric patients.C.
Mashaly GE, Zeid MS.
europepmc +4 more sources
Metabolome and Transcriptome Combinatory Profiling Reveals Fluconazole Resistance Mechanisms of Trichosporon asahii and the Role of Farnesol in Fluconazole Tolerance [PDF]
Microorganisms, 2023 Yu Gu, Xiaoping Ma, Guangneng Peng
exaly +1 more source
Genotypes, Fluconazole Tolerance and Virulence Phenotypes of Candida albicans Bloodstream Isolates: A Multilocus Sequence Typing-Based Analysis. [PDF]
MycosesBackground Fluconazole tolerance is an emerging phenotype in Candida albicans bloodstream infections, but its ...
Lin SY +5 more
europepmc +2 more sources
Fluconazole tolerance in clinical isolates of Cryptococcus neoformans [PDF]
Antimicrobial Agents and Chemotherapy, 1997 Eleven isolates of Cryptococcus neoformans were investigated to determine the biochemical basis of their tolerance to fluconazole. The MICs of fluconazole for three isolates with low-level resistance were 3- to 6-fold higher than those for sensitive isolates, while the MICs for four isolates with high-level resistance were 100- to 200-fold higher than ...
K, Venkateswarlu +4 more
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Microbiology Spectrum, 2021 The high morbidity and mortality of cryptococcal meningitis is due to the limited range of therapeutic options: only three classes of antifungal drugs are available (polyenes [amphotericin B], azoles [fluconazole], and pyrimidine analogues [flucytosine]).
Feng Yang +6 more
doaj +1 more source
Tolerability of long-term fluconazole therapy [PDF]
Journal of Antimicrobial Chemotherapy, 2018 Fluconazole is a commonly prescribed first-generation triazole antifungal. Although the toxicity profile of fluconazole has been evaluated in clinical trials, there are scant data regarding its tolerability with long-term therapy. Treatment guidelines for coccidioidomycosis recommend fluconazole therapy and severe or disseminated infections can require
Matthew R, Davis +3 more
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Gene Duplication Associated with Increased Fluconazole Tolerance in Candida auris cells of Advanced Generational Age. [PDF]
Sci Rep, 2019 AbstractCandida auris is an emerging multi-drug resistant yeast that causes systemic infections. Here we show that C. auris undergoes replicative aging (RA) that results from asymmetric cell division and causes phenotypic differences between mother and daughter cells similar to other pathogenic yeasts. Importantly, older C. auris cells (10 generations)
Bhattacharya S +3 more
europepmc +4 more sources
PLoS Pathogens, 2023 Fungal pathogens overcome antifungal drug therapy by classic resistance mechanisms, such as increased efflux or changes to the drug target. However, even when a fungal strain is susceptible, trailing or persistent microbial growth in the presence of an ...
Ka Pui Sharon Yau +7 more
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