Fluconazole-COX Inhibitor Hybrids: A Dual-Acting Class of Antifungal Azoles
, 2022 When used in combination with azole antifungal drugs, cyclooxygenase (COX) inhibitors such as ibuprofen improve antifungal efficacy. We report the conjugation of a chiral antifungal azole pharmacophore to COX inhibitors and the evaluation of activity of ...
Pallabita Basu (12009955) +2 more
core +2 more sources
Nitrogen concentration affects amphotericin B and fluconazole tolerance of pathogenic cryptococci [PDF]
FEMS Yeast Research, 2020 ABSTRACT Environmental stress often causes phenotypic changes among pathogenic cryptococci, such as altered antifungal susceptibility, changes in capsule and melanin formation, as well as altered levels of the membrane sterol and antifungal target, ergosterol.
Caylin Bosch +4 more
openaire +2 more sources
Tolerance to fluconazole in Candida albicans is regulated by temperature and aneuploidy
Access Microbiology, 2021 Candida albicans is a prevalent human fungal pathogen. Azoles are the most widely used antifungal drugs. Drug tolerance in bacteria is well defined and thoroughly studied, but in fungi, the definition of drug tolerance and the mechanism that drive it are not well understood. Here, we found that a large proportion of clinical isolates
FENG YANG, YUANYING JIANG, JUDITH BERMAN
openaire +1 more source
mBio, 2023 Antifungal drug tolerance is a response distinct from resistance, in which cells grow slowly above the MIC. Here, we found that the majority (69.2%) of 133 Candida albicans clinical isolates, including standard lab strain SC5314, exhibited temperature ...
Feng Yang +7 more
doaj +1 more source
Systematic truncations of chromosome 4 and their responses to antifungals in Candida albicans
Journal of Genetic Engineering and Biotechnology, 2021 Background Candida albicans is an opportunistic human fungal pathogen responsible for superficial and systemic life-threatening infections. Treating these infections is challenging as many clinical isolates show increased drug resistance to antifungals ...
Wasim Uddin +3 more
doaj +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
CAQ Corner: Immune‐mediated complications
, 2022 Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley +1 more source
Frontiers in Microbiology, 2021 Recurrent vulvovaginal candidiasis (RVVC) is one of the most prevalent fungal infections in humans, especially in developing countries; however, it is underestimated and regarded as an easy-to-treat condition.
Amir Arastehfar +18 more
doaj +1 more source
A Prospective Longitudinal Study of the Clinical Outcomes from Cryptococcal Meningitis following Treatment Induction with 800 mg Oral Fluconazole in Blantyre, Malawi [PDF]
, 2013 Introduction: Cryptococcal meningitis is the most common neurological infection in HIV infected patients in Sub Saharan Africa, where gold standard treatment with intravenous amphotericin B and 5 flucytosine is often unavailable or difficult to ...
Mavuto Mukaka +49 more
core +1 more source
A prospective study of mortality from cryptococcal meningitis following treatment induction with 1200 mg oral fluconazole in Blantyre, Malawi. [PDF]
, 2014 OBJECTIVE: We have previously reported high ten-week mortality from cryptococcal meningitis in Malawian adults following treatment-induction with 800 mg oral fluconazole (57% [33/58]).
Allain, TJ +52 more
core +1 more source