Results 31 to 40 of about 5,860 (175)

Metabolome and Transcriptome Combinatory Profiling Reveals Fluconazole Resistance Mechanisms of Trichosporon asahii and the Role of Farnesol in Fluconazole Tolerance [PDF]

Microorganisms, 2023
Xiaoping Ma, Sanjie Cao, Guangneng Peng   +2 more
exaly   +1 more source

Induction of Antifungal Tolerance Reveals Genetic and Phenotypic Changes in Candida glabrata

Journal of Fungi
Candida glabrata is an opportunistic, pathogenic fungus that is increasingly isolated from hospitalized patients. The incidence of drug tolerance, heteroresistance, and resistance is on the rise due to an overuse of antifungal drugs.
Christy Chedraoui, Nour Fattouh, Setrida El Hachem, Maria Younes, Roy A. Khalaf   +4 more
doaj   +2 more sources

Fluconazole tolerance in clinical isolates of Cryptococcus neoformans [PDF]

Antimicrobial Agents and Chemotherapy, 1997
Eleven isolates of Cryptococcus neoformans were investigated to determine the biochemical basis of their tolerance to fluconazole. The MICs of fluconazole for three isolates with low-level resistance were 3- to 6-fold higher than those for sensitive isolates, while the MICs for four isolates with high-level resistance were 100- to 200-fold higher than ...
K, Venkateswarlu, M, Taylor, N J, Manning, M G, Rinaldi, S L, Kelly   +4 more
openaire   +4 more sources

Fluconazole-COX Inhibitor Hybrids: A Dual-Acting Class of Antifungal Azoles

, 2022
When used in combination with azole antifungal drugs, cyclooxygenase (COX) inhibitors such as ibuprofen improve antifungal efficacy. We report the conjugation of a chiral antifungal azole pharmacophore to COX inhibitors and the evaluation of activity of ...
Pallabita Basu (12009955), Micha Fridman (1419856), Rebecca Elias (5235533)   +2 more
core   +2 more sources

Gene Duplication Associated with Increased Fluconazole Tolerance in Candida auris cells of Advanced Generational Age. [PDF]

Sci Rep, 2019
AbstractCandida auris is an emerging multi-drug resistant yeast that causes systemic infections. Here we show that C. auris undergoes replicative aging (RA) that results from asymmetric cell division and causes phenotypic differences between mother and daughter cells similar to other pathogenic yeasts. Importantly, older C. auris cells (10 generations)
Bhattacharya S, Holowka T, Orner EP, Fries BC.   +3 more
europepmc   +4 more sources

Adaptation to Fluconazole via Aneuploidy Enables Cross-Adaptation to Amphotericin B and Flucytosine in Cryptococcus neoformans

Microbiology Spectrum, 2021
The high morbidity and mortality of cryptococcal meningitis is due to the limited range of therapeutic options: only three classes of antifungal drugs are available (polyenes [amphotericin B], azoles [fluconazole], and pyrimidine analogues [flucytosine]).
Feng Yang, Vladimir Gritsenko, Hui Lu, Cheng Zhen, Lu Gao, Judith Berman, Yuan-ying Jiang   +6 more
doaj   +1 more source

Tolerability of long-term fluconazole therapy [PDF]

Journal of Antimicrobial Chemotherapy, 2018
Fluconazole is a commonly prescribed first-generation triazole antifungal. Although the toxicity profile of fluconazole has been evaluated in clinical trials, there are scant data regarding its tolerability with long-term therapy. Treatment guidelines for coccidioidomycosis recommend fluconazole therapy and severe or disseminated infections can require
Matthew R, Davis, Minh-Vu H, Nguyen, Monica A, Donnelley, George R, Thompson Iii   +3 more
openaire   +2 more sources

Nitrogen concentration affects amphotericin B and fluconazole tolerance of pathogenic cryptococci [PDF]

FEMS Yeast Research, 2020
ABSTRACT Environmental stress often causes phenotypic changes among pathogenic cryptococci, such as altered antifungal susceptibility, changes in capsule and melanin formation, as well as altered levels of the membrane sterol and antifungal target, ergosterol.
Caylin Bosch, Barbra Toplis, Jo-Marie Vreulink, Heinrich Volschenk, Alfred Botha   +4 more
openaire   +2 more sources

Tolerance to fluconazole in Candida albicans is regulated by temperature and aneuploidy

Access Microbiology, 2021
Candida albicans is a prevalent human fungal pathogen. Azoles are the most widely used antifungal drugs. Drug tolerance in bacteria is well defined and thoroughly studied, but in fungi, the definition of drug tolerance and the mechanism that drive it are not well understood. Here, we found that a large proportion of clinical isolates
FENG YANG, YUANYING JIANG, JUDITH BERMAN
openaire   +1 more source

Systematic truncations of chromosome 4 and their responses to antifungals in Candida albicans

Journal of Genetic Engineering and Biotechnology, 2021
Background Candida albicans is an opportunistic human fungal pathogen responsible for superficial and systemic life-threatening infections. Treating these infections is challenging as many clinical isolates show increased drug resistance to antifungals ...
Wasim Uddin, Darshan Dhabalia, S. M. Udaya Prakash, M. Anaul Kabir   +3 more
doaj   +1 more source