Results 51 to 60 of about 5,632 (146)

Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in Candida albicans

mSphere, 2017
Regulated erroneous protein translation (adaptive mistranslation) increases proteome diversity and produces advantageous phenotypic variability in the human pathogen Candida albicans.
Tobias Weil, Rodrigo Santamaría, Wanseon Lee, Johan Rung, Noemi Tocci, Darren Abbey, Ana R. Bezerra, Laura Carreto, Gabriela R. Moura, Mónica Bayés, Ivo G. Gut, Attila Csikasz-Nagy, Duccio Cavalieri, Judith Berman, Manuel A. S. Santos   +14 more
doaj   +1 more source

Genomic Diversity across Candida auris Clinical Isolates Shapes Rapid Development of Antifungal Resistance In Vitro and In Vivo

mBio, 2022
Antifungal drug resistance and tolerance pose a serious threat to global public health. In the human fungal pathogen, Candida auris, resistance to triazole, polyene, and echinocandin antifungals is rising, resulting in multidrug resistant isolates. Here,
Laura S. Burrack, Robert T. Todd, Natthapon Soisangwan, Nathan P. Wiederhold, Anna Selmecki   +4 more
doaj   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Study of tolerance ability in phosphate solubilising microorganisms isolated from tea plantations soil of lower Darjeeling hills

Bulletin of the National Research Centre, 2021
Background Tea is an important plantation crop in India and world. Introduction of fertilisers and pesticides for better production polluted tea garden soils.
Sumedha Saha, Sukanya Acharyya, Sahadeb Sarkar, Malay Bhattacharya   +3 more
doaj   +1 more source

Treatment Goals for Primary Biliary Cholangitis, an Australian Perspective

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Primary biliary cholangitis (PBC) is an autoimmune liver disease that targets the small intrahepatic bile ducts with diagnosis based on elevated serum alkaline phosphatase (ALP) levels and the presence of anti‐mitochondrial antibodies. Untreated, it may run a progressive course to cirrhosis and hepatic decompensation, at which point liver ...
Simone I. Strasser, Alexander J. Thompson, Rohit Gupta, John Lubel, Janine French, Beverly Sacks, Martin Weltman   +6 more
wiley   +1 more source

392. Evaluation of the Long-Term Tolerability and Efficacy of Fluconazole in Patients With Coccidioidomycosis [PDF]

Open Forum Infectious Diseases, 2018
BACKGROUND: Invasive fungal infections within the United States continue to increase annually and represent a significant cause of morbidity and mortality. Fluconazole is a first-generation triazole antifungal used in the treatment of several fungal infections including coccidioidomycosis. Treatment guidelines for coccidioidomycosis recommend high-dose
openaire   +1 more source

Identification and Elimination of Antifungal Tolerance in Candida auris

Biomedicines, 2023
Antimicrobial resistance is a global health crisis to which pathogenic fungi make a substantial contribution. The human fungal pathogen C. auris is of particular concern due to its rapid spread across the world and its evolution of multidrug resistance ...
Samira Rasouli Koohi, Shamanth A. Shankarnarayan, Clare Maristela Galon, Daniel A. Charlebois   +3 more
doaj   +1 more source

Antimicrobial photodynamic therapy in Candida spp. biofilms: In vitro and in vivo protocols

Photochemistry and Photobiology, EarlyView.
This review addresses the critical challenges in translating in vitro antimicrobial photodynamic therapy protocols to in vivo models, with a particular focus on the hurdles of standardization. The vast diversity in photosensitizers and light parameters across different target cells and models requires a rigorous optimization process.
Lívia Mara Alves Figueiredo‐Godoi, Ana Júlia Barbosa Tomé, Cristina Kurachi   +2 more
wiley   +1 more source

An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens

Cell Reports, 2015
There is an urgent need to identify new treatments for fungal infections. By combining sub-lethal concentrations of the known antifungals fluconazole, caspofungin, amphotericin B, terbinafine, benomyl, and cyprodinil with ∼3,600 compounds in diverse ...
Nicole Robbins, Michaela Spitzer, Tennison Yu, Robert P. Cerone, Anna K. Averette, Yong-Sun Bahn, Joseph Heitman, Donald C. Sheppard, Mike Tyers, Gerard D. Wright   +9 more
doaj   +1 more source

Unlocking the Multifunctional Properties of Litsea cubeba Essential Oil: Composition, Antimicrobial, Antibiofilm and Insecticidal Activities

Flavour and Fragrance Journal, Volume 41, Issue 5, Page 1201-1216, September 2026.
Unveiling the chemical and biological properties of Litsea cubeba essential oil. ABSTRACT Litsea cubeba essential oil (LCEO) is recognised for its broad spectrum of biological activities, including antimicrobial and insecticidal effects, making it a promising natural alternative to synthetic agents.
Miroslava Kačániová, Minhang Qiao, Alessandro Bianchi, Joel Horacio Elizondo‐Luevano, Anis Ben Hsouna, Rania Ben Saad, Zhaojun Ban, Li Li, Jian Lou, Wissem Mnif, Stefania Garzoli   +10 more
wiley   +1 more source