Results 71 to 80 of about 5,860 (175)

PBPK Modeling and Clinical Data Reveal Reduced Impact of CYP3A4 and CYP2C9 Inhibitors on Elimination of Siponimod

Clinical and Translational Science, Volume 19, Issue 7, July 2026.
ABSTRACT Multiple sclerosis (MS) is a significant cause of neurological disability in young adults. Siponimod, a potent sphingosine‐1‐phosphate (S1P) receptor modulator, is used to treat MS by reducing T‐cell recirculation and central inflammation. The presented work includes clinical data describing the impact of the CYP3A4 inhibitor clarithromycin on
Felix Huth, Kasra Shakeri‐Nejad, Anne Gardin, Bharti Shah, Oliver Pohl, Nicole Pezous, Thomas Faller   +6 more
wiley   +1 more source

Pharmacokinetic/pharmacodynamic modelling approaches in paediatric infectious diseases and immunology [PDF]

, 2014
Pharmacokinetic/pharmacodynamic (PKPD) modelling is used to describe and quantify dose-concentration-effect relationships. Within paediatric studies in infectious diseases and immunology these methods are often applied to developing guidance on ...
Hoare, RL, Germovsek, Eva, Standing, JF, Standing, Joseph F., Lewis, J, Barker, Charlotte I.S., Lewis, Joanna, Lestner, Jodi M., Hoare, Rollo L., Barker, CI, Germovsek, E, Lestner, JM   +11 more
core   +1 more source

The Role of Enterococcus faecium in the Synergistic Clearance of High‐Risk HPV: A Clinical Study on Cervicovaginal Microbiota Regulation

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Persistent infection with high‐risk human papillomavirus (HR‐HPV) is defined as the principal cause of cervical cancer. Given the important role of cervicovaginal microbiota in HPV acquisition and disease progression, this study aims to evaluate the clinical efficacy of the probiotic Enterococcus faecium (E.
Jun Yang, Mengya Gao, Danfeng Wang, Ziwei Li, Sijing Li, Min Zhou, Li‐Na Hu   +6 more
wiley   +1 more source

Antifungal susceptibilities of Cryptococcus species complex isolates from AIDS and non-AIDS patients in Southeast China

Brazilian Journal of Infectious Diseases
Cryptococcus spp. are common causes of mycoses in immunocompromised patients. To determine the drug susceptibilities of clinical Cryptococcus spp. isolates, the characteristics of 61 clinical Cryptococcus spp.
Meng Li, Yong Liao, Min Chen, Weihua Pan, Lixing Weng   +4 more
doaj   +1 more source

Comprehensive Analysis of Artemisia argyi H. Lév. & Vaniot Essential Oil: Chemical Composition, Antimicrobial Efficacy, Biofilm Disruption, and Insecticidal Potential

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Comprehensive analyses, including GC–MS profiling, antimicrobial and antibiofilm assays, vapor‐phase application, and insecticidal evaluation, reveal the strong multifunctional potential for practical use in food and agricultural protection of Artemisia argyi EO.
Miroslava Kačániová, Zhaojun Ban, Li Li, Jian Lou, Joel Horacio Elizondo‐Luevano, Anis Ben Hsouna, Rania Ben Saad, Alessandro Bianchi, Ladislav Bakay, Stefania Garzoli   +9 more
wiley   +1 more source

Pharmacological and Phytochemical Insights Into Ficus benghalensis (Indian Banyan): Anti‐Inflammatory, Antioxidant, and Anticancer Potentials

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
The aim of this review is to critically evaluate the therapeutic potential of Ficus benghalensis L. by integrating ethnomedicinal knowledge with contemporary scientific evidence. The objectives are to summarize its phytochemical profile, analyze antioxidant, antimicrobial, antidiabetic, anti‐inflammatory, and anticancer activities, elucidate underlying
Zainab Ali, Farhang Hameed Awlqadr, Uswa Ali, Iffat Ullah, Muhammad Tayyab Arshad, Abdul Rauf, Humaira Parveen, Sayeed Mukhtar, Uzma Faridi, Md. Sakhawot Hossain   +9 more
wiley   +1 more source

Fluconazole for the management of invasive candidiasis: Where do we stand after 15 years? [PDF]

, 2006
Candida spp. are responsible for most of the fungal infections in humans. Available since 1990, fluconazole is well established as a leading drug in the setting of prevention and treatment of mucosal and invasive candidiasis.
Ribaud, P., Lortholary, Oliver, Hart, E., Charlier, C., Denning, D. W.; id_orcid, Dromer, F., Lefort, A.   +6 more
core   +1 more source

Donor‐Related Factors Affecting Haploidentical HSCT Outcomes in Acute Leukemia: A Single‐Center Retrospective Cohort Study of a Modified Combination of Anti‐Thymocyte Globulin and Post‐Transplant Cyclophosphamide

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Haploidentical hematopoietic stem cell transplantation (haplo‐HSCT) provides curative therapy for patients lacking HLA‐matched donors, yet optimal donor characteristics remain uncertain. This study assessed the effect of donor relationship, age, sex, and ABO compatibility on outcomes of haplo‐HSCT for acute leukemia under a
Mahtab Mashayekhi, Sahar Saeidi, Ghazaleh Kheiri, Fatemeh Salemi, Marjan Masoud, Sahar Tavakoli, Hanieh Rouzbahani, Mohammad Vaezi, Mohammadreza Ostadali Dehaghi, Mojtaba Azari, Ghasem Janbabai, Maryam Barkhordar   +11 more
wiley   +1 more source

Fungal‐Bacterial Interactions in Polymicrobial Infections: Hidden Threats

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
ABSTRACT Polymicrobial infections involving fungi and bacteria represent a major and increasingly recognized clinical challenge, in which interkingdom interactions significantly amplify disease severity, antimicrobial resistance, and treatment failure. Rather than passive co‐existence, fungal–bacterial communities form highly coordinated systems driven
Mohammad Javad Roustaye Gourabi, Masoud Kargar, Atefeh Kamali, Javad Yasbolaghi Sharahi   +3 more
wiley   +1 more source

Mechanisms of immune evasion and drug tolerance in Candida albicans

, 2021
Candida albicans is a major opportunistic pathogen of humans. In immunocompromised patients, C. albicans becomes pathogenic and can cause Oropharyngeal candidiasis, Vulvovaginal candidiasis and Invasive candidiasis.
Yang, Mengli
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