Results 61 to 70 of about 605,588 (181)

Enhanced Tolerance to Antifungals as a General Feature of Rho⁻ Mutants in Yeast Species: Implications to Positive Selection of Respiratory Deficiency

Microorganisms
Although the mitochondrial genome is an attribute of all eukaryotes, some yeast species (called petite-positive) can replicate without mitochondrial DNA (mtDNA).
Zachary Johnson, Farhan Nadim, Mikhajlo K. Zubko   +2 more
doaj   +1 more source

Antifungal susceptibilities of Cryptococcus species complex isolates from AIDS and non-AIDS patients in Southeast China

Brazilian Journal of Infectious Diseases, 2012
Cryptococcus spp. are common causes of mycoses in immunocompromised patients. To determine the drug susceptibilities of clinical Cryptococcus spp. isolates, the characteristics of 61 clinical Cryptococcus spp.
Meng Li, Yong Liao, Min Chen, Weihua Pan, Lixing Weng   +4 more
doaj   +1 more source

Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species

Antioxidants
Fluconazole (FLC) is extensively employed for the prophylaxis and treatment of invasive fungal infections (IFIs). However, the fungistatic nature of FLC renders pathogenic fungi capable of developing tolerance towards it.
Wanqian Li, Yanru Feng, Zhe Feng, Li Wang, Malcolm Whiteway, Hui Lu, Yuanying Jiang   +6 more
doaj   +1 more source

Investigation of the relationship between fluconazole susceptibility, proteinase activity and ERG11-SAP2 Expression in Candida albicans strains isolated from clinical samples [PDF]

Current Medical Mycology
Background and Purpose: Candida albicans is currently recognised as an opportunistic pathogen that can cause many invasive infections. Resistance mechanisms and fungal virulence factors play an important role in the effectiveness of treatment. The aim of
Nagihan Ege, Şükrü Öksüz, Emel Akbaş, Emel Çalişkan, Mehmet Sungur   +4 more
doaj   +1 more source

Genomic Diversity across Candida auris Clinical Isolates Shapes Rapid Development of Antifungal Resistance In Vitro and In Vivo

mBio, 2022
Antifungal drug resistance and tolerance pose a serious threat to global public health. In the human fungal pathogen, Candida auris, resistance to triazole, polyene, and echinocandin antifungals is rising, resulting in multidrug resistant isolates. Here,
Laura S. Burrack, Robert T. Todd, Natthapon Soisangwan, Nathan P. Wiederhold, Anna Selmecki   +4 more
doaj   +1 more source

The Impact of Common Medications on Male Fertility: An Updated Systematic Review

Andrology, EarlyView.
ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli, Salomé Gallissian, Roxanne Barèges, Félicia Fournier, Catherine Metzler‐Guillemain, Ségolène Prades, Fanny Magnan‐Sebag, Jeanne Perrin   +7 more
wiley   +1 more source

Tolerance of Muslim beliefs and practices: Age related differences and context effects [PDF]

, 2007
Tolerant judgments of Muslims’ political rights and dissenting beliefs and practices by ethnic Dutch adolescents (12–18 years) were examined. Participants (N = 632) made judgments of different types of behaviors and different contexts in an experimental ...
Slooter, Luuk, Verkuyten, Maykel, Verkuyten, Maykel,, Slooter, Luuk,   +3 more
core   +2 more sources

Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in Candida albicans

mSphere, 2017
Regulated erroneous protein translation (adaptive mistranslation) increases proteome diversity and produces advantageous phenotypic variability in the human pathogen Candida albicans.
Tobias Weil, Rodrigo Santamaría, Wanseon Lee, Johan Rung, Noemi Tocci, Darren Abbey, Ana R. Bezerra, Laura Carreto, Gabriela R. Moura, Mónica Bayés, Ivo G. Gut, Attila Csikasz-Nagy, Duccio Cavalieri, Judith Berman, Manuel A. S. Santos   +14 more
doaj   +1 more source

Preventing infections after CD19‐directed chimeric antigen receptor T‐cell therapies for lymphoma: a consensus practice statement

Internal Medicine Journal, EarlyView.
Abstract Chimeric antigen receptor (CAR) T‐cell therapies directed against cluster of differentiation 19 (CD19) are a standard of care for relapsed or refractory B‐cell lymphomas. Infection is the leading cause of non‐relapse mortality, and this risk may persist for years after CAR T‐cell receipt.
Aine Hurley, Philip George, Gemma Reynolds, Adam Stewart, Hang Quach, Nicole O'Leary, Zoe McQuilten, Andrea S. Henden, Lynette Chee, Chan Y. Cheah, Olivia Bupha‐Intr, Emily Blyth, Ben Teh, Monica Slavin, Michael Dickinson, Robert Weinkove   +15 more
wiley   +1 more source

Hsp21potentiates antifungal drug tolerance in Candida albicans [PDF]

, 2013
Peer ...
Hube Bernhard, Wilson Duncan, Duncan Wilson, Bernhard Hube, Mayer, François L, Hube, Bernhard, Mayer François L., Wilson, Duncan, François L Mayer   +8 more
core   +2 more sources