Results 61 to 70 of about 5,632 (146)

Candida albicans Genetic Background Influences Mean and Heterogeneity of Drug Responses and Genome Stability during Evolution in Fluconazole

mSphere, 2020
The importance of within-species diversity in determining the evolutionary potential of a population to evolve drug resistance or tolerance is not well understood, including in eukaryotic pathogens.
Aleeza C. Gerstein, Judith Berman
doaj   +1 more source

Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to antifungal compounds

eLife, 2023
Candida albicans, an opportunistic human pathogen, poses a significant threat to human health and is associated with significant socio-economic burden. Current antifungal treatments fail, at least in part, because C.
Vanessa Dumeaux, Samira Massahi, Van Bettauer, Austin Mottola, Anna Dukovny, Sanny Singh Khurdia, Anna Carolina Borges Pereira Costa, Raha Parvizi Omran, Shawn Simpson, Jinglin Lucy Xie, Malcolm Whiteway, Judith Berman, Michael T Hallett   +12 more
doaj   +1 more source

Multifunctional Properties of Wintergreen (Gaultheria procumbens) Essential Oil: Antimicrobial, Antibiofilm, and Insecticidal Effects

Flavour and Fragrance Journal, Volume 41, Issue 5, Page 1245-1261, September 2026.
Unveiling the potential of Wintergreen (Gaultheria procumbens) essential oil. ABSTRACT This study investigated the antimicrobial, antibiofilm, and insecticidal properties of wintergreen (Gaultheria procumbens L.) essential oil (GPEO). The EO was chemically characterized by GC–MS, confirming methyl salicylate as the predominant compound (99.3%).
Miroslava Kačániová, Minhang Qiao, Alessandro Bianchi, Joel Horacio Elizondo‐Luevano, Anis Ben Hsouna, Rania Ben Saad, Zhaojun Ban, Li Li, Jian Lou, Wissem Mnif, Stefania Garzoli   +10 more
wiley   +1 more source

In vitro exposure to the agricultural triazole tebuconazole selects for fluconazole cross−resistance and echinocandin tolerance in Candidozyma auris

Frontiers in Cellular and Infection Microbiology
The agricultural triazole fungicide tebuconazole (TCZ) has been implicated in the emergence of azole resistance in human fungal pathogens, but its direct role in selecting resistance and tolerance in Candidozyma auris remains unclear.
Lihao Peng, Yi Xu, Xinyi Chen, Wenhui Li, Liangsheng Guo   +4 more
doaj   +1 more source

Integrated Evaluation of the Multifunctional Bioactivity of Curcuma zedoaria (Christm.) Roscoe Essential Oil: Antimicrobial, Insecticidal, and Postharvest Effects on Fresh Ginger

eFood, Volume 7, Issue 4, August 2026.
Multifunctional bioactivity of Curcuma zedoaria essential oil. ABSTRACT Plant‐derived essential oils are increasingly investigated as sustainable alternatives for food preservation and crop protection; however, their multifunctional applicability under postharvest conditions remains insufficiently explored.
Miroslava Kačániová, Minhang Qiao, Joel Horacio Elizondo‐Luevano, Zhaojun Ban, Li Li, Yizhou Gao, Anis Ben Hsouna, Rania Ben Saad, Maciej Ireneusz Kluz, Stefania Garzoli   +9 more
wiley   +1 more source

Antifungal susceptibilities of Cryptococcus species complex isolates from AIDS and non-AIDS patients in Southeast China

Brazilian Journal of Infectious Diseases
Cryptococcus spp. are common causes of mycoses in immunocompromised patients. To determine the drug susceptibilities of clinical Cryptococcus spp. isolates, the characteristics of 61 clinical Cryptococcus spp.
Meng Li, Yong Liao, Min Chen, Weihua Pan, Lixing Weng   +4 more
doaj   +1 more source

Factor XI Inhibition for Ischemic Stroke Secondary Prevention: Pharmacology, Clinical Evidence, and Future Directions

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Ischemic stroke remains a leading cause of death and disability worldwide, and bleeding (particularly intracranial hemorrhage) continues to limit conventional antithrombotic therapy in secondary prevention, even with direct oral anticoagulants.
Federica Ferrari, Roberto Federico Villa
wiley   +1 more source

Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence.

PLoS Pathogens, 2010
Candida albicans, the major fungal pathogen of humans, causes life-threatening infections in immunocompromised individuals. Due to limited available therapy options, this can frequently lead to therapy failure and emergence of drug resistance. To improve
Elias Epp, Ghyslaine Vanier, Doreen Harcus, Anna Y Lee, Gregor Jansen, Michael Hallett, Don C Sheppard, David Y Thomas, Carol A Munro, Alaka Mullick, Malcolm Whiteway   +10 more
doaj   +1 more source

Effects of the HDAC6/8 Inhibitor MC1568, Alone and in Combination With Fluconazole, in Non‐Albicans Candida Species Infections

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
This study explores new antifungal strategies to combat non‐albicans Candida species. We tested clinically approved HDAC inhibitors—Vorinostat, Romidepsin, Tucidinostat—and the HDAC6/8‐selective MC1568, alone and with Fluconazole. The Fluconazole/MC1568 combination significantly enhanced antifungal activity and reduced biofilm formation.
Andrea Giammarino, Chiara Lambona, Alessia Raucci, Giovanna Simonetti, Salvatore Macrì, Angela Iuzzolino, Daniela Trisciuoglio, Sergio Valente, Gustavo Giusiano, Letizia Angiolella, Antonello Mai   +10 more
wiley   +1 more source

From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Recent and limited evidence indicates that oral candidiasis can disseminate Candida albicans throughout the body, leading to invasive candidiasis, such as candidemia, a life‐threatening infection. Considering antifungal resistance and global outbreaks of emergent non‐albicans Candida and related yeasts, murine models help understand dissemination ...
Julia Robledo Jerez, Marcella Vieira Ambrosio, Marcela Eduarda Olegario Fernandes, Ewerton Garcia de Oliveira Mima   +3 more
wiley   +1 more source