Results 81 to 90 of about 605,588 (181)

Synthesis, Antiparasitic Activity, and ADME Profile of Morpholinephenylbenzamides: A Pharmacological Study Against Chagas Disease and Visceral Leishmaniasis

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Hit‐to‐lead optimization of morpholinephenylbenzamides reveals key structure–activity relationships against Trypanosoma cruzi and Leishmania infantum. Potency, selectivity, and ADME properties are differentially improved across the series, identifying compounds 20, 24, and 16 as complementary templates for the future design of dual antiparasitic leads.
Danilo Nascimento Farago, Daniela de Melo Resende, Mariza Gabriela Faleiro de Moura Lodi Cruz, Rafaela Marçal Sousa, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Felipe da Silva Mendonça de Melo, Douglas Davison da Silva Oliveira, Paula Derksen Macruz, Alexandra Maria dos Santos Carvalho, Eduardo Jorge Pilau, Izabela Marques Dourado Bastos, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +15 more
wiley   +1 more source

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3656-3665, October 2026.
Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson, Deeyen Karsanji, Bonifride Tuyishimire, Joanna Parkinson, Maria Heijer, Tadeusz Pawlik, Judith Hartleib‐Geschwindner, Maria Leonsson‐Zachrisson, Hans Ericsson   +8 more
wiley   +1 more source

Antifungal susceptibilities of Cryptococcus species complex isolates from AIDS and non-AIDS patients in Southeast China

Brazilian Journal of Infectious Diseases
Cryptococcus spp. are common causes of mycoses in immunocompromised patients. To determine the drug susceptibilities of clinical Cryptococcus spp. isolates, the characteristics of 61 clinical Cryptococcus spp.
Meng Li, Yong Liao, Min Chen, Weihua Pan, Lixing Weng   +4 more
doaj   +1 more source

Nicotinamide and Sodium Butyrate Double the Pool of Treatment‐Exclusive Metabolites in the Endophytic Fungus Curvularia sp. G6‐32

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Epigenetic modulators nicotinamide and sodium butyrate reshape the chemical landscape of the endophytic fungus Curvularia sp. G6‐32. Combining the OSMAC strategy with UHPLC‐MS/MS metabolomics and molecular networking reveals a more than twofold rise in treatment‐exclusive metabolites, including diketopiperazines and potentially bioactive natural ...
Guilherme Edison Almeida Pega, Laís Stella Perassolli Nicchio, Andressa Domingos Polli, Francielli Alana Pereira Valeze, Évelin Lemos de Oliveira, Eduardo Cesar Meurer, Débora Cristina Baldoqui, João Lúcio Azevedo, Julio Cesar Polonio   +8 more
wiley   +1 more source

Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence.

PLoS Pathogens, 2010
Candida albicans, the major fungal pathogen of humans, causes life-threatening infections in immunocompromised individuals. Due to limited available therapy options, this can frequently lead to therapy failure and emergence of drug resistance. To improve
Elias Epp, Ghyslaine Vanier, Doreen Harcus, Anna Y Lee, Gregor Jansen, Michael Hallett, Don C Sheppard, David Y Thomas, Carol A Munro, Alaka Mullick, Malcolm Whiteway   +10 more
doaj   +1 more source

The Power of Hematopoietic Stem Cell Transplantation (HSCT): A Curative Approach for Diffuse Large B‐Cell Lymphoma (DLBCL) Incidentally Detected in a SCID Baby

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Lymphoma is a rare complication of X‐linked severe combined immunodeficiency (X‐SCID) caused by IL2RG deficiency. We report an infant with IL2RG‐SCID who developed diffuse large B‐cell lymphoma (DLBCL) during pretransplant evaluation. A male infant with T−B+ SCID was diagnosed at 1 month of age and referred for hematopoietic stem cell ...
Burcu Sarıgül Cimi, Sule Haskologlu, Candan Islamoglu, Gokcan Ozturk, Nazlı Deveci, Hasret Erkmen, Selin Sevinc, Can Akal, Seda Kaynak Sahap, Sonay Özdemir, Suat Fitoz, Isınsu Kuzu, Emel Unal, Nurdan Tacyıldız, Figen Dogu, Aydan Ikinciogullari   +15 more
wiley   +1 more source

Effects of Fluconazole on the Metabolomic Profile of Candida albicans

, 2016
Background - Little is known about the effects of fluconazole on the metabolism of Candida albicans. We performed LC/MS-based metabolomic profiling of the response of C. albicans cells to increasing doses of fluconazole. Methods - C.
Katragkou, A., Alexander, E.L., Walsh, T.J., Raheem, S., Eoh, H., Roilides, E.   +5 more
core   +1 more source

Aspergillus niger as a New Endophytic Fungus From Deverra tortuosa: Phytochemical Profile, Molecular Docking, Antimicrobial, Antibiofilm, Antioxidant, and Anticancer Activities

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Aspergillus niger AA1 isolated from Deverra tortuosa produced a metabolite‐rich extract with antibacterial, antibiofilm, antioxidant, and selective anticancer activities. Gas chromatography–mass spectrometry identified major bioactive compounds, while molecular docking supported their interactions with DNA gyrase B and estrogen receptor alpha ...
Samy Selim, Amr H. Hashem, Amer Morsy Abdelaziz, Mohamed H. Sharaf, Samiah Hamad Al‐Mijalli, Mohammed Aladhadh, Emad M. Abdallah, Mohammed H. Alruhaili, Hattan S. Gattan, Alaa A. Kashmiry, Mohammed Aufy   +10 more
wiley   +1 more source

Antifungal Activity Assessment of Postbiotic Mediators Derived From Lactobacillus rhamnosus GG and Lactobacillus reuteri Against Candida albicans

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Postbiotic metabolites derived from Lactobacillus rhamnosus GG and Lactobacillus reuteri demonstrate potent antifungal and anti‐biofilm activity against Candida albicans. By significantly impairing fungal viability, metabolic activity, and biofilm structural integrity, these non‐viable compounds offer a promising, safe alternative for managing oral ...
Fatemeh Amirinia, Morteza Banakar, Mojgan Alaeddini, Shahroo Etemad‐Moghadam, Maryam Pourhajibagher, Maryam Noori   +5 more
wiley   +1 more source

Vaginal azoles versus oral fluconazole in treatment of recurrent vulvovaginal candidiasis [PDF]

Background: Vulvovaginal candidiasis (VVC) is a fungal infection of the vagina and vulva. It is usually caused by Candida albicans, however, occasionally other candida species are responsible. The optimal treatment of VVC has not yet been defined.
فردی آذر, زهرا, عبدالهی فرد, صدیقه, تلو, مهشید, حبیب زاده, شهرام   +3 more
core