Results 81 to 90 of about 5,632 (146)

The Neosartorya (Aspergillus) fischeri antifungal protein NFAP2 has low potential to trigger resistance development in Candida albicans in vitro

Microbiology Spectrum
Due to the increase in the number of drug-resistant Candida albicans strains, new antifungal compounds with limited potential for the development of resistance are urgently needed.
Gábor Bende, Nóra Zsindely, Krisztián Laczi, Zsolt Kristóffy, Csaba Papp, Attila Farkas, Liliána Tóth, Szabolcs Sáringer, László Bodai, Gábor Rákhely, Florentine Marx, László Galgóczy   +11 more
doaj   +1 more source

Sterol‐Targeted Laboratory Evolution Allows the Isolation of Thermotolerant and Respiratory‐Competent Clones of the Industrial Yeast Saccharomyces cerevisiae

Microbial Biotechnology
Sterol composition plays a crucial role in determining the ability of yeast cells to withstand high temperatures, an essential trait in biotechnology.
Isabel‐Elena Sánchez‐Adriá, Jose A. Prieto, Gemma Sanmartín, Miguel Morard, Estéfani García‐Ríos, Francisco Estruch, Francisca Randez‐Gil   +6 more
doaj   +1 more source

The zinc cluster transcription factor Znc1 regulates Rta3-dependent miltefosine resistance in Candida albicans

mSphere
Zinc cluster transcription factors (ZCFs) are a family of transcription regulators that are almost exclusively found in the fungal kingdom. Activating mutations in the ZCFs Mrr1, Tac1, and Upc2 frequently cause acquired resistance to the widely used ...
Bernardo Ramírez-Zavala, Ines Krüger, Sonja Schwanfelder, Katherine S. Barker, P. David Rogers, Joachim Morschhäuser   +5 more
doaj   +1 more source

Identification and characterization of mediators of fluconazole tolerance in Candida albicans

, 2019
Candida spp. are major human pathogens and a major issue in intensive care units around the world. Candida infections have a high mortality rate despite the use of antifungal treatments. One cause of these therapeutic failures is the acquisition of mutations in the fungus leading to antifungal resistance.
openaire   +1 more source

Temporal transcriptional response of Candida glabrata during macrophage infection reveals a multifaceted transcriptional regulator CgXbp1 important for macrophage response and fluconazole resistance

eLife
Candida glabrata can thrive inside macrophages and tolerate high levels of azole antifungals. These innate abilities render infections by this human pathogen a clinical challenge. How C.
Maruti Nandan Rai, Qing Lan, Chirag Parsania, Rikky Rai, Niranjan Shirgaonkar, Ruiwen Chen, Li Shen, Kaeling Tan, Koon Ho Wong   +8 more
doaj   +1 more source

Suspected Macrolide-Refractory Mycoplasma pneumoniae Pneumonia With Discordant Coccidioides Serology in an Immunocompromised Host: A Case Report

Case Reports in Infectious Diseases
Suspected macrolide-refractory Mycoplasma pneumoniae pneumonia can be a diagnostic challenge in immunocompromised hosts, particularly after allogeneic stem cell transplantation. Screening serologies may further complicate diagnosis when false-positive or
Mohamed M. G. Mohamed, Garry Francis Morel, Matthew Stack, John Salomone, Ariel Rischall, Ghassan Kamel   +5 more
doaj   +1 more source

Ovoid cell is an inducible small-sized morphotype that enhances proliferation and antifungal drug tolerance in the human fungal pathogen Cryptococcus neoformans. [PDF]

PLoS Pathog
Zhang X, Shu X, Liu Y, Zhao Y, Chen H, Xiong F, Kang M, Cao C.   +7 more
europepmc   +1 more source

Peroxin Pex8 couples stress responses, antifungal tolerance, and virulence regulation in <i>Candida albicans</i>. [PDF]

Antimicrob Agents Chemother
Xi B, Wu Y.
europepmc   +1 more source

Identification of positive and negative mediators of fluconazole tolerance in Candida albicans [PDF]

, 2018
openaire   +1 more source

The azole-resistance phenotype of a <i>Nakaseomyces glabratus</i> clinical strain encoding a wild-type <i>PDR1</i> allele involves the efflux pumps Aus1 and Pdh1 and Cyb5, an alternative reductase required for ergosterol biosynthesis. [PDF]

Microbiol Spectr
Pinheiro MJ, Parker JE, Ferreira MT, Fernandes F, Mira NP.   +4 more
europepmc   +1 more source