Results 101 to 110 of about 5,860 (175)

In-vitro activity of D0870, a new triazole antifungal drug, in comparison with fluconazole and itraconazole against Aspergillus fumigatus and Candida krusei

, 1997
The activity of the new triazole antifungal D0870 was compared with those of itraconazole and fluconazole against Candida krusei and Aspergillus fumigatus, two fungi showing inherent tolerance of fluconazole.
Venkateswarlu, K., Kelly, S. L., Denning, D. W.; id_orcid, Venkat Kanamarlapudi   +3 more
core   +1 more source

The zinc cluster transcription factor Znc1 regulates Rta3-dependent miltefosine resistance in Candida albicans

mSphere
Zinc cluster transcription factors (ZCFs) are a family of transcription regulators that are almost exclusively found in the fungal kingdom. Activating mutations in the ZCFs Mrr1, Tac1, and Upc2 frequently cause acquired resistance to the widely used ...
Bernardo Ramírez-Zavala, Ines Krüger, Sonja Schwanfelder, Katherine S. Barker, P. David Rogers, Joachim Morschhäuser   +5 more
doaj   +1 more source

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

Fluconazole-Resistant Candida auris Is Susceptible to Salivary Histatin 5 Killing and to Intrinsic Host Defenses

, 2018
Candida auris is a newly identified species causing invasive candidemia and candidiasis. It has broad multidrug resistance (MDR) not observed for other pathogenic Candida species.
Ruvini U. Pathirana, Jason Kay, Ornella Salvatori, Andrew D. McCall, Mira Edgerton, Hannah L. Norris, Justin Friedman   +6 more
core   +1 more source

Temporal transcriptional response of Candida glabrata during macrophage infection reveals a multifaceted transcriptional regulator CgXbp1 important for macrophage response and fluconazole resistance

eLife
Candida glabrata can thrive inside macrophages and tolerate high levels of azole antifungals. These innate abilities render infections by this human pathogen a clinical challenge. How C.
Maruti Nandan Rai, Qing Lan, Chirag Parsania, Rikky Rai, Niranjan Shirgaonkar, Ruiwen Chen, Li Shen, Kaeling Tan, Koon Ho Wong   +8 more
doaj   +1 more source

Identification and characterization of mediators of fluconazole tolerance in Candida albicans

, 2019
Candida spp. are major human pathogens and a major issue in intensive care units around the world. Candida infections have a high mortality rate despite the use of antifungal treatments. One cause of these therapeutic failures is the acquisition of mutations in the fungus leading to antifungal resistance.
openaire   +1 more source

Genomic analysis of antifungal drug resistance and tolerance, and centromere structure in budding yeasts

Candida parapsilosis is an emerging opportunistic fungal pathogen increasingly associated with fluconazole treatment failures. In Chapter 2 of this thesis, we examined both fluconazole resistance and tolerance in 386 C. parapsilosis isolates.
Hession, Conor
core  

Distinct effect of calorie restriction between congenic mating types of Cryptococcus neoformans

Scientific Reports
Cryptococcus neoformans (Cn) is an opportunistic yeast that causes meningoencephalitis in immunocompromised individuals. Calorie restriction (CR) prolongs Cn replicative lifespan (RLS) and mimics low-glucose environments in which Cn resides during ...
Natalia Kronbauer Oliveira, Kyungyoon Yoo, Somanon Bhattacharya, Rina Gambhir, Nigina Kirgizbaeva, Pilar Arcones García, Ignacio Pompa Prados, Caroline Mota Fernandes, Maurizio Del Poeta, Bettina C. Fries   +9 more
doaj   +1 more source

Evolutionary dynamics of Candida albicans in the presence and absence of antifungal drug fluconazole

Candida albicans, the most prevalent human fungal pathogen, demonstrates remarkable adaptability and genome plasticity, enabling it to thrive in diverse environments within the human body.
Sumanarathne, Aruni
core  

Influence of fluconazole drug-dosing regimen on the rate of adaptation and extinction in Candida albicans

Invasive infections caused by human fungal pathogens are a global health concern due to high mortality and morbidity rates. Many fungal infections are caused by species from the genus Candida. The most common, Candida albicans, is both a commensal member
Sethi, Parul
core