Results 91 to 100 of about 605,588 (181)

An Integrated Metabolomics and Bioactivity Approach to Characterize Salvia heldreichiana and Salvia tomentosa Extracts

ChemistryOpen, Volume 15, Issue 10, October 2026.
S. heldreichiana and S. tomentosa can be considered as effective sources of natural bioactive agents for further in vivo pharmacological evaluation and development. The genus Salvia, widely known as sage, represents the largest group within the Lamiaceae family and includes numerous species with traditional uses.
Gokhan Zengin, Nilofar Nilofar, Alina Kalyniukova, Vasil Andruch, Giancarlo Angeles Flores, Paola Angelini, Roberto Venanzoni, Kubra Aslan, Ilhami Gulcin, Evren Yildiztugay   +9 more
wiley   +1 more source

MOLECULAR MECHANISMS OF DRUG RESISTANCE IN CANDIDA ALBICANS: ROLE OF TRANSCRIPTION FACTORS MCM1 AND ADA2 [PDF]

, 2011
Candida albicans is an opportunistic fungal pathogen responsible for localized as well as disseminated infections. C. albicans is the most commonly isolated specie from blood cultures, accounting for over 60% of all Candida isolates. The fungistatic drug
MOGAVERO, SELENE
core  

Expanding the Donor Pool in Pediatric Transplantations: Successful Domino Liver Transplantation From the Youngest Reported Pediatric DCD Donor Using Normothermic Regional Perfusion in the United States

Pediatric Transplantation, Volume 30, Issue 10, October 2026.
ABSTRACT Introduction Normothermic regional perfusion (NRP) during donation after circulatory death (DCD) improves abdominal organ utilization by limiting warm ischemia time. Its application in young pediatric donors remains exceptionally rare; the youngest previously reported DCD‐NRP donor in the United States was 5 years of age.
Anastasia M. Kahan, Francisca van der Schyff, Alan G. Contreras, Dave N. Peterson, M. Kyle Jensen, Jill Sweney, Lindsey N. Troy, Jean F. Botha, Zachary J. Kastenberg   +8 more
wiley   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

The coevolution of virulence : tolerance in perspective [PDF]

, 2010
Coevolutionary interactions, such as those between host and parasite, predator and prey, or plant and pollinator, evolve subject to the genes of both interactors.
Colegrave, Nick, Colegrave Nick, Tom J. Little, David M Shuker, Day, Troy, Tom J Little, Graham Andrea L., Nick Colegrave, Little, Tom J., Troy Day, Shuker David M., Graham, Andrea L., Andrea L. Graham, Little Tom J., David M. Shuker, Day Troy, Shuker, David M., Andrea L Graham   +17 more
core   +2 more sources

Step-wise evolution of azole resistance through copy number variation followed by KSR1 loss of heterozygosity in Candida albicans.

PLoS Pathogens
Antimicrobial drug resistance poses a global health threat, requiring a deeper understanding of the evolutionary processes that lead to its emergence in pathogens. Complex evolutionary dynamics involve multiple mutations that can result in cooperative or
Pétra Vande Zande, Cécile Gautier, Nora Kawar, Corinne Maufrais, Katura Metzner, Elizabeth Wash, Annette K Beach, Ryan Bracken, Eli Isael Maciel, Nívea Pereira de Sá, Caroline Mota Fernandes, Norma V Solis, Maurizio Del Poeta, Scott G Filler, Judith Berman, Iuliana V Ene, Anna Selmecki   +16 more
doaj   +1 more source

Profile of Candida Resistancy to Fluconazole in Male Patient with Oral Candidiasis and HIV/AIDS [PDF]

, 2019
Background: Oral candidiasis is one of the most common opportunistic infections found in patients with Human Immunodeficiency Virus (HIV)/Acquired immune deficiency syndrome (AIDS). The number of HIV/AIDS patient increases every years.
Dwi Murtiastutik, Rahmadewi, Cut Shelma Maharani   +2 more
core   +1 more source

Universal Screening of Tanzanian HIV-Infected Adult Inpatients with the Serum Cryptococcal Antigen to Improve Diagnosis and Reduce Mortality: An Operational Study. [PDF]

, 2011
Cryptococcal meningitis is a leading cause of death among HIV-infected individuals in sub-Saharan Africa. Recent developments include the availability of intravenous fluconazole, cryptococcal antigen assays and new data to support fluconazole pre-emptive
Fitzgerald, Daniel W, Wajanga, Bahati Mk, Samuel Kalluvya, Bahati MK Wajanga, Daniel W Fitzgerald, Peck, Robert N, Jennifer A Downs, Warren D Johnson, Downs, Jennifer A, Johnson, Warren D, Robert N Peck, Kalluvya, Samuel   +11 more
core   +1 more source

Induction of Antifungal Tolerance Reveals Genetic and Phenotypic Changes in Candida glabrata

Journal of Fungi
Candida glabrata is an opportunistic, pathogenic fungus that is increasingly isolated from hospitalized patients. The incidence of drug tolerance, heteroresistance, and resistance is on the rise due to an overuse of antifungal drugs.
Christy Chedraoui, Nour Fattouh, Setrida El Hachem, Maria Younes, Roy A. Khalaf   +4 more
doaj   +1 more source

Tolerance to the antifungal drug fluconazole is mediated by tuning cytoplasmic fluidity

Abstract Treatment failure rates for fungal infections cannot be explained simply by increased rates of drug resistance. Antifungal drug tolerance, the ability of a susceptible isolate to grow in the presence of inhibitory drug concentrations, relies upon a broad set of stress response pathways and can contribute to antifungal drug ...
Plumb, E., Serrano, A., Chevalier, Louis, Elferich, J., Sinn, L.R., Grigorieff, N., Ralser, Markus, Berman, Judith, Bassilana, M., Arkowitz, R.A.   +9 more
openaire   +1 more source