Antifungal Tolerance and Resistance Emerge at Distinct Drug Concentrations and Rely upon Different Aneuploid Chromosomes [PDF]
mBio, 2023 Antifungal drug tolerance is a response distinct from resistance, in which cells grow slowly above the MIC. Here, we found that the majority (69.2%) of 133 Candida albicans clinical isolates, including standard lab strain SC5314, exhibited temperature ...
Feng Yang +7 more
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Toward the consensus of definitions for the phenomena of antifungal tolerance and persistence in filamentous fungi [PDF]
mBioAntifungal drug tolerance and persistence are being increasingly recognized in fungal pathogens. Accordingly, more and more research is being carried out to characterize and understand these phenomena. However, the terminology and methodology employed in
Jorge Amich +3 more
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Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia [PDF]
Nature Communications, 2018 The authors show that antifungal tolerance, defined as the fraction of growth of a fungal pathogen above the minimal inhibitory concentration, is due to the slow growth of subpopulations of cells that overcome drug stress, and that high tolerance is ...
Alexander Rosenberg +9 more
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The role of Candida albicans stress response pathways in antifungal tolerance and resistance [PDF]
iScience, 2022 Summary: Human fungal pathogens are the causative agents of devastating diseases across the globe, and the increasing prevalence of drug resistance threatens to undermine the already limited treatment options.
Kali R. Iyer +2 more
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Identification and Elimination of Antifungal Tolerance in Candida auris [PDF]
Biomedicines, 2023 Antimicrobial resistance is a global health crisis to which pathogenic fungi make a substantial contribution. The human fungal pathogen C. auris is of particular concern due to its rapid spread across the world and its evolution of multidrug resistance ...
Samira Rasouli Koohi +3 more
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mSphere of Influence: Diagnosis of antifungal tolerance and persistence [PDF]
mSphereLei Chen works in the field of clinical diagnosis of antifungal tolerance and persistence. In this mSphere of Influence, he reflects on how the papers “Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with ...
Lei Chen
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Aneuploidy enables cross-tolerance to unrelated antifungal drugs in Candida parapsilosis
Frontiers in Microbiology, 2023 Candida parapsilosis is an emerging major human fungal pathogen. Echinocandins are first-line antifungal drugs for the treatment of invasive Candida infections.
Liu-liu Sun +7 more
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Induction of Antifungal Tolerance Reveals Genetic and Phenotypic Changes in Candida glabrata [PDF]
Journal of FungiCandida glabrata is an opportunistic, pathogenic fungus that is increasingly isolated from hospitalized patients. The incidence of drug tolerance, heteroresistance, and resistance is on the rise due to an overuse of antifungal drugs.
Christy Chedraoui +4 more
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Frontiers in MicrobiologyBackgroundThe emergence of tolerance to antifungal agents in Candida albicans complicates the treatment of fungal infections. Understanding the mechanisms underlying this tolerance is crucial for developing effective therapeutic strategies.ObjectiveThis ...
Lijun Zheng +3 more
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Profound cell wall remodeling in Candida parapsilosis during systemic infection confers simultaneous tolerance to echinocandins and host immunity [PDF]
Microbiology SpectrumAntifungal tolerance can promote the emergence of resistance yet often incurs fitness costs for fungal pathogens. How tolerant populations compensate for these deficits and how they may be therapeutically targeted remain poorly understood.
Farnaz Daneshnia +28 more
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