mSphere of Influence: Diagnosis of antifungal tolerance and persistence [PDF]
MSphereLei Chen works in the field of clinical diagnosis of antifungal tolerance and persistence. In this mSphere of Influence, he reflects on how the papers “Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with ...
Lei Chen
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Toward the consensus of definitions for the phenomena of antifungal tolerance and persistence in filamentous fungi. [PDF]
MBioAntifungal drug tolerance and persistence are being increasingly recognized in fungal pathogens. Accordingly, more and more research is being carried out to characterize and understand these phenomena. However, the terminology and methodology employed in
Gustavo H. Goldman +2 more
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Antifungal Tolerance and Resistance Emerge at Distinct Drug Concentrations and Rely upon Different Aneuploid Chromosomes. [PDF]
MBio, 2023 Antifungal drug tolerance is a response distinct from resistance, in which cells grow slowly above the MIC. Here, we found that the majority (69.2%) of 133 Candida albicans clinical isolates, including standard lab strain SC5314, exhibited temperature ...
Eduardo Scopel Ferreira da Costa +1 more
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Identification and Elimination of Antifungal Tolerance in Candida auris [PDF]
Biomedicines, 2023 Antimicrobial resistance is a global health crisis to which pathogenic fungi make a substantial contribution. The human fungal pathogen C. auris is of particular concern due to its rapid spread across the world and its evolution of multidrug resistance ...
Samira Rasouli Koohi +3 more
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Peroxin Pex8 couples stress responses, antifungal tolerance, and virulence regulation in Candida albicans [PDF]
Antimicrobial Agents and ChemotherapyCandida albicans, a World Health Organization critical-priority fungal pathogen, represents the predominant cause of candidemia. Therapeutic failure is sometimes driven by antifungal tolerance, a phenotype distinct from resistance, whose underlying ...
Bangsheng Xi, Yongqin Wu
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ER stress selects for Candida auris survivors with acquired fluconazole resistance and caspofungin tolerance [PDF]
Frontiers in MicrobiologyExposure to endoplasmic reticulum (ER) stress can drive the emergence of antifungal resistance in pathogenic fungi, but the underlying mechanisms remain poorly understood.
Feng Yang +6 more
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Aneuploidy enables cross-tolerance to unrelated antifungal drugs in Candida parapsilosis
Frontiers in Microbiology, 2023 Candida parapsilosis is an emerging major human fungal pathogen. Echinocandins are first-line antifungal drugs for the treatment of invasive Candida infections.
Yuan-Ying Jiang
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Induction of Antifungal Tolerance Reveals Genetic and Phenotypic Changes in Candida glabrata [PDF]
Journal of FungiCandida glabrata is an opportunistic, pathogenic fungus that is increasingly isolated from hospitalized patients. The incidence of drug tolerance, heteroresistance, and resistance is on the rise due to an overuse of antifungal drugs.
Christy Chedraoui +4 more
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Iron starvation confers azole tolerance in Aspergillus fumigatus hyphae via mitochondrial function modulation [PDF]
mBioAntifungal tolerance, a transient survival state distinct from genetic resistance, poses a significant challenge to antifungal therapy. However, the factors that induce antifungal tolerance and their underlying mechanisms remain poorly understood.
Longyun Cong +4 more
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Nature Communications, 2018 The authors show that antifungal tolerance, defined as the fraction of growth of a fungal pathogen above the minimal inhibitory concentration, is due to the slow growth of subpopulations of cells that overcome drug stress, and that high tolerance is ...
Richard J Bennett +2 more
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