Results 21 to 30 of about 32,347 (265)

Miconazole induces aneuploidy-mediated tolerance in Candida albicans that is dependent on Hsp90 and calcineurin [PDF]

Frontiers in Cellular and Infection Microbiology
Antifungal resistance and antifungal tolerance are two distinct terms that describe different cellular responses to drugs. Antifungal resistance describes the ability of a fungus to grow above the minimal inhibitory concentration (MIC) of a drug ...
Liangsheng Guo, Lijun Zheng, Yubo Dong, Chen Wang, Huijie Deng, Zongjie Wang, Yi Xu   +6 more
doaj   +2 more sources

The Neosartorya (Aspergillus) fischeri antifungal protein NFAP2 has low potential to trigger resistance development in Candida albicans in vitro

Microbiology Spectrum
Due to the increase in the number of drug-resistant Candida albicans strains, new antifungal compounds with limited potential for the development of resistance are urgently needed.
Gábor Bende, Nóra Zsindely, Krisztián Laczi, Zsolt Kristóffy, Csaba Papp, Attila Farkas, Liliána Tóth, Szabolcs Sáringer, László Bodai, Gábor Rákhely, Florentine Marx, László Galgóczy   +11 more
doaj   +2 more sources

High Efficiency Drug Repurposing Design for New Antifungal Agents

Methods and Protocols, 2019
Current antifungal interventions have often limited efficiency in treating fungal pathogens, particularly those resistant to commercial drugs or fungicides.
Jong H. Kim, Kathleen L. Chan, Luisa W. Cheng, Lisa A. Tell, Barbara A. Byrne, Kristin Clothier, Kirkwood M. Land   +6 more
doaj   +3 more sources

Quantifying and Mitigating Antifungal Tolerance in the Pathogenic Yeast Candida auris

Candida auris is an emerging pathogen that has been detected on five continents and is linked to resistance against the main three classes of antifungal drugs used to treat invasive infections, leading to healthcare-associated outbreaks. Tolerance refers
Rasouli Koohi, Samira
core   +2 more sources

The mitochondrial protein Bcs1A regulates antifungal drug tolerance by affecting efflux pump expression in the filamentous pathogenic fungus Aspergillus fumigatus

Microbiology Spectrum
Aspergillus fumigatus is the predominant pathogen responsible for aspergillosis infections, with emerging drug-resistant strains complicating treatment strategies.
Guorong Yang, Weiwei Shi, Wenlin He, Jing Wu, Sutao Huang, Li Mo, Junjie Zhang, Huaxue Wang, Xiaogang Zhou   +8 more
doaj   +2 more sources

Multifactorial Mechanisms of Tolerance to Ketoconazole in Candida albicans

Microbiology Spectrum, 2021
Candida albicans is a prevalent opportunistic human fungal pathogen for which treatment is limited to only four main classes of antifungal drugs, with the azole and echinocandin classes being used most frequently.
Yi Xu, Hui Lu, Shuo Zhu, Wan-Qian Li, Yuan-ying Jiang, Judith Berman, Feng Yang   +6 more
doaj   +1 more source

Tolerability profile of the current antifungal armoury [PDF]

Journal of Antimicrobial Chemotherapy, 2018
AbstractThe tolerability of available antifungal agents is essential to the final outcome of the management of invasive mycoses. There are limited classes of antifungal agents for use, and they can have serious direct toxicities and/or drug–drug interactions.
Ahmad, Mourad, John R, Perfect
openaire   +2 more sources

Tunicamycin Potentiates Antifungal Drug Tolerance via Aneuploidy in Candida albicans

mBio, 2021
How cells exposed to one stress are later able to better survive other types of stress is not well understood. In eukaryotic organisms, physiological and pathological stresses can disturb endoplasmic reticulum (ER) function, resulting in “ER stress ...
Feng Yang, Vladimir Gritsenko, Yaniv Slor Futterman, Lu Gao, Cheng Zhen, Hui Lu, Yuan-ying Jiang, Judith Berman   +7 more
doaj   +1 more source

Salt-Tolerant Antifungal and Antibacterial Activities of the Corn Defensin ZmD32 [PDF]

Frontiers in Microbiology, 2019
Copyright © 2019 Kerenga, McKenna, Harvey, Quimbar, Garcia-Ceron, Lay, Phan, Veneer, Vasa, Parisi, Shafee, van der Weerden, Hulett, Craik, Anderson and Bleackley. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Kerenga, Bomai K, McKenna, James, Harvey, Peta J, Quimbar Dominguez, Pedro, Garcia-Ceron, Donovan, Lay, Fung, Phan, Kha, Veneer, Prem, Vasa, Shaily, Parisi, Kathy, Shafee, Thomas, Van Der Weerden, Nicole, Hulett, Mark, Craik, David J, Anderson, Marilyn, Bleackley, Mark   +15 more
openaire   +7 more sources

Biofilm Formation of Candida albicans Facilitates Fungal Infiltration and Persister Cell Formation in Vaginal Candidiasis

Frontiers in Microbiology, 2020
BackgroundVaginal candidiasis is an important medical condition awaiting more effective treatment. How Candida albicans causes this disease and survives antifungal treatment is not yet fully understood.
Xueqing Wu, Xueqing Wu, Sisi Zhang, Haiying Li, Laien Shen, Chenle Dong, Yao Sun, Huale Chen, Boyun Xu, Wenyi Zhuang, Margaret Deighton, Yue Qu, Yue Qu   +12 more
doaj   +1 more source