Diverse effects of calcineurin in vascular smooth muscle cells: physiological activators and the controversial actions of clinical inhibitors [PDF]
Frontiers in PharmacologyCalcineurin is a serine/threonine phosphatase that classically regulates T cell activation and modulates immune response by targeting transcription factors of the NFaT family.
Alexander Nolze, Claudia Grossmann
doaj +2 more sources
Neurobiology of Disease, 2009 Calcineurin is a serine/threonine phosphatase involved in the regulation of glutamate receptors signaling. Here, we analyzed whether the regulation of calcineurin protein levels and activity modulates the susceptibility of striatal neurons to ...
Xavier Xifró +2 more
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Calcineurin Targets Involved in Stress Survival and Fungal Virulence. [PDF]
PLoS Pathogens, 2016 Calcineurin governs stress survival, sexual differentiation, and virulence of the human fungal pathogen Cryptococcus neoformans. Calcineurin is activated by increased Ca2+ levels caused by stress, and transduces signals by dephosphorylating protein ...
Hee-Soo Park +6 more
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Calcineurin Is a Universal Regulator of Vessel Function—Focus on Vascular Smooth Muscle Cells
Cells, 2023 Calcineurin, a serine/threonine phosphatase regulating transcription factors like NFaT and CREB, is well known for its immune modulatory effects and role in cardiac hypertrophy.
Alexander Nolze +2 more
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Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans. [PDF]
PLoS Genetics, 2017 Calcineurin is a highly conserved Ca2+/calmodulin-dependent serine/threonine-specific protein phosphatase that orchestrates cellular Ca2+ signaling responses.
Eve W L Chow +7 more
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Calpain-Mediated Cleavage of Calcineurin in Puromycin Aminonucleoside-Induced Podocyte Injury. [PDF]
PLoS ONE, 2016 The calcineurin inhibitors cyclosporine A (CsA) and tacrolimus are widely used in the treatment of proteinuria diseases. As the direct target of these drugs, calcineurin has previously been demonstrated to play a role in proteinuria diseases.
Fangrui Ding +5 more
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mBio, 2022 In this study, 18 predicted membrane-localized ABC transporters of Candida glabrata were deleted individually to create a minilibrary of knockouts (KO). The transporter KOs were analyzed for their susceptibility toward antimycotic drugs.
Sonam Kumari +9 more
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Multifactorial Mechanisms of Tolerance to Ketoconazole in Candida albicans
Microbiology Spectrum, 2021 Candida albicans is a prevalent opportunistic human fungal pathogen for which treatment is limited to only four main classes of antifungal drugs, with the azole and echinocandin classes being used most frequently.
Yi Xu +6 more
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Preventive effect of tacrolimus on patients with post-endoscopic retrograde cholangiopancreatography pancreatitis [PDF]
Clinical Endoscopy, 2022 Background/Aims In patients undergoing endoscopic retrograde cholangiopancreatography (ERCP), calcineurin activates zymogen, which results in pancreatitis.
Harshavardhan Rao B. +4 more
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Cell Communication and Signaling, 2023 The calcium-responsive phosphatase, calcineurin, senses changes in Ca2+ concentrations in a calmodulin-dependent manner. Here we report that under non-stress conditions, inactivation of calcineurin signaling or deleting the calcineurin-dependent ...
Srishti Chawla +6 more
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