Results 21 to 30 of about 78,892 (304)
Frontiers in Molecular Biosciences, 2023 Introduction: Rise in Calcium (Ca2+) and hyperactive Ca2+-dependent phosphatase calcineurin represent two key determinants of a-synuclein (a-syn) pathobiology implicated in Parkinson’s Disease (PD) and other neurodegenerative diseases.
Sofia Zaichick, Gabriela Caraveo
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Differential involvement of hippocampal calcineurin during learning and reversal learning in a Y-maze task [PDF]
, 2006 The regulation and function of the calcium-dependent phosphatase calcineurin (CaN, protein phosphatase 2B) in learning and memory remain unclear, although recent work indicates that CaN may play a differential role in training and reversal training.
Havekes, Robbert, +8 more
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Calcineurin Inhibitor Toxicity in Solid Organ Transplantation
, 2021 Calcineurin inhibitors (CNIs) have a substantial role in maintaining immunosuppression after solid organ transplantation (SOT). These drugs have a narrow therapeutic window, and individual doses and drug treatment monitoring are necessary.
Vera Genitsch +5 more
core +1 more source
Biomolecules, 2021 Calcineurin (CaN) is present in all eukaryotic cells, including intracellular trypanosomatid parasites such as Trypanosoma cruzi (Tc) and Leishmania spp. (Lspp).
Patricio R. Orrego +3 more
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Kidney and Dialysis, 2023 Chronic kidney disease—mineral and bone disorder (CKD-MBD) plays a significant role in causing cardiovascular morbidity and mortality related to CKD.
Evdokia Bogdanova +8 more
doaj +1 more source
Cells, 2021 Mitochondrial autophagy (or mitophagy) is essential for mitochondrial quality control, which is critical for cellular and organismal health by attenuating reactive oxygen species generation and maintaining bioenergy homeostasis.
Seon Beom Song +3 more
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Targeting CaN/NFAT in Alzheimer’s brain degeneration
Frontiers in Immunology, 2023 Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a progressive loss of cognitive functions. While the exact causes of this debilitating disorder remain elusive, numerous investigations have characterized its two core pathologies:
Joanna Mackiewicz +2 more
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Membranes, 2021 Regulation of the Ca2+-activated Cl− channel TMEM16A by Ca2+/calmodulin (CAM) is discussed controversially. In the present study, we compared regulation of TMEM16A by Ca2+/calmodulin (holo-CAM), CAM-dependent kinase (CAMKII), and CAM-dependent ...
Khaoula Talbi +4 more
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A novel calcineurin splice variant that modifies calcineurin activity [PDF]
European Journal of Biochemistry, 2001 Calcineurin is a Ca2+/calmodulin dependent phosphoprotein phosphatase implicated in a wide range of disorders. Here, we report the cloning of a novel calcineurin Aα splice variant that lacks both the catalytic and calcineurin B binding domains. Biochemical analysis revealed a stimulating effect on calcineurin activity at low calcium concentrations as ...
A, Reuter +4 more
openaire +2 more sources
Cell Calcium, 2021 The protein phosphatase calcineurin has long been familiar to the calcium community, but the definition of its physiological substrates has been far from complete. A new study rectifies this deficiency and sets the stage for new insights into the role of calcineurin in diverse cellular processes.
Huiming Li, Patrick G. Hogan
openaire +3 more sources