Results 21 to 30 of about 82,791 (297)

Histone Deacetylase 6 Inhibitor CKD-WID Suppressed Monosodium Urate-Induced Osteoclast Formation by Blocking Calcineurin-NFAT Pathway in RAW 264.7 Cells

Pharmaceuticals, 2023
Histone deacetylase (HDAC) has been found to play a crucial role in the regulation of osteoclast differentiation and formation. This study was designed to identify the effect of the HDAC6 inhibitor CKD-WID on the receptor for the activation of nuclear ...
Seong-Kyu Kim, Jung-Yoon Choe, Ji-Won Kim, Ki-Yeun Park   +3 more
doaj   +1 more source

Calcineurin Regulates Conidiation, Chlamydospore Formation and Virulence in Fusarium oxysporum f. sp. lycopersici

Frontiers in Microbiology, 2020
Fusarium wilt of tomato caused by the ascomycetous fungus Fusarium oxysporum f. sp. lycopersici (Fol) is widespread in most tomato planting areas. Calcineurin is a heterodimeric calcium/calmodulin-dependent protein phosphatase comprised of catalytic ...
Yi-Hsuan Hou, Li-Hang Hsu, Hsuan-Fu Wang, Yu-Hsin Lai, Ying-Lien Chen   +4 more
doaj   +1 more source

Elucidation of GPR55-Associated Signaling behind THC and LPI Reducing Effects on Ki67-Immunoreactive Nuclei in Patient-Derived Glioblastoma Cells

Cells, 2023
GPR55 is involved in many physiological and pathological processes. In cancer, GPR55 has been described to show accelerating and decelerating effects in tumor progression resulting from distinct intracellular signaling pathways.
Marc Richard Kolbe, Tim Hohmann, Urszula Hohmann, Erik Maronde, Ralph Golbik, Julian Prell, Jörg Illert, Christian Strauss, Faramarz Dehghani   +8 more
doaj   +1 more source

Harnessing IGF-1 and IL-2 as biomarkers for calcineurin activity to tailor optimal FK506 dosage in α-synucleinopathies

Frontiers in Molecular Biosciences, 2023
Introduction: Rise in Calcium (Ca2+) and hyperactive Ca2+-dependent phosphatase calcineurin represent two key determinants of a-synuclein (a-syn) pathobiology implicated in Parkinson’s Disease (PD) and other neurodegenerative diseases.
Sofia Zaichick, Gabriela Caraveo
doaj   +1 more source

Differential involvement of hippocampal calcineurin during learning and reversal learning in a Y-maze task [PDF]

, 2006
The regulation and function of the calcium-dependent phosphatase calcineurin (CaN, protein phosphatase 2B) in learning and memory remain unclear, although recent work indicates that CaN may play a differential role in training and reversal training.
Havekes, Robbert,, Luiten, Paul G. M., Havekes, Robbert, Nijholt, Ingrid M.,, van der Zee, Eddy A., Havekes, Robbert; id_orcid, Nijholt, Ingrid M., Luiten, Paul G.M.,, Zee, Eddy A. van der,   +8 more
core   +2 more sources

In Silico Characterization of Calcineurin from Pathogenic Obligate Intracellular Trypanosomatids: Potential New Biological Roles

Biomolecules, 2021
Calcineurin (CaN) is present in all eukaryotic cells, including intracellular trypanosomatid parasites such as Trypanosoma cruzi (Tc) and Leishmania spp. (Lspp).
Patricio R. Orrego, Mayela Serrano-Rodríguez, Mauro Cortez, Jorge E. Araya   +3 more
doaj   +1 more source

Myocardial Remodeling in Early Chronic Kidney Disease—Mineral and Bone Disorder Model with Low Bone Turnover

Kidney and Dialysis, 2023
Chronic kidney disease—mineral and bone disorder (CKD-MBD) plays a significant role in causing cardiovascular morbidity and mortality related to CKD.
Evdokia Bogdanova, Airat Sadykov, Galina Ivanova, Irina Zubina, Olga Beresneva, Olga Galkina, Marina Parastaeva, Vladimir Sharoyko, Vladimir Dobronravov   +8 more
doaj   +1 more source

Nicotinamide Treatment Facilitates Mitochondrial Fission through Drp1 Activation Mediated by SIRT1-Induced Changes in Cellular Levels of cAMP and Ca²⁺

Cells, 2021
Mitochondrial autophagy (or mitophagy) is essential for mitochondrial quality control, which is critical for cellular and organismal health by attenuating reactive oxygen species generation and maintaining bioenergy homeostasis.
Seon Beom Song, Jin Sung Park, So Young Jang, Eun Seong Hwang   +3 more
doaj   +1 more source

Targeting CaN/NFAT in Alzheimer’s brain degeneration

Frontiers in Immunology, 2023
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a progressive loss of cognitive functions. While the exact causes of this debilitating disorder remain elusive, numerous investigations have characterized its two core pathologies:
Joanna Mackiewicz, Malwina Lisek, Tomasz Boczek   +2 more
doaj   +1 more source

Calmodulin-Dependent Regulation of Overexpressed but Not Endogenous TMEM16A Expressed in Airway Epithelial Cells

Membranes, 2021
Regulation of the Ca2+-activated Cl− channel TMEM16A by Ca2+/calmodulin (CAM) is discussed controversially. In the present study, we compared regulation of TMEM16A by Ca2+/calmodulin (holo-CAM), CAM-dependent kinase (CAMKII), and CAM-dependent ...
Khaoula Talbi, Jiraporn Ousingsawat, Raquel Centeio, Rainer Schreiber, Karl Kunzelmann   +4 more
doaj   +1 more source