Results 31 to 40 of about 82,791 (297)
Cell Calcium, 2021 The protein phosphatase calcineurin has long been familiar to the calcium community, but the definition of its physiological substrates has been far from complete. A new study rectifies this deficiency and sets the stage for new insights into the role of calcineurin in diverse cellular processes.
Huiming Li, Patrick G. Hogan
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Frontiers in Molecular Neuroscience, 2017 In the present study, we generated and characterized a splice site-specific monoclonal antibody that selectively detects the calcineurin-binding dynamin1 splice variant dynamin1xb.
Marie-Lisa Eich +5 more
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A novel calcineurin splice variant that modifies calcineurin activity [PDF]
European Journal of Biochemistry, 2001 Calcineurin is a Ca2+/calmodulin dependent phosphoprotein phosphatase implicated in a wide range of disorders. Here, we report the cloning of a novel calcineurin Aα splice variant that lacks both the catalytic and calcineurin B binding domains. Biochemical analysis revealed a stimulating effect on calcineurin activity at low calcium concentrations as ...
A, Reuter +4 more
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eLifeCalcineurin is a highly conserved calcium/calmodulin-dependent serine/threonine protein phosphatase with diverse functions. Inhibition of calcineurin is known to enhance the lifespan of Caenorhabditis elegans through multiple signaling pathways.
Priyanka Das +2 more
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Calcineurin in development and disease
Genes & Diseases, 2022 Calcineurin (CaN) is a unique calcium (Ca2+) and calmodulin (CaM)-dependent serine/threonine phosphatase that becomes activated in the presence of increased intracellular Ca2+ level. CaN then functions to dephosphorylate target substrates including various transcription factors, receptors, and channels.
Lei Chen, Min Song, Chunyan Yao
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Calcineurin in cancer signaling networks [PDF]
Calcium/calcineurin/nuclear factor of activated T-cell signaling is a vital regulator of the development and function of immune, nervous, cardiovascular, and musculoskeletal systems.
Tsubota, Shomas +2 more
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Pathogens, 2015 Studies on fungal pathogens belonging to the ascomycota phylum are critical given the ubiquity and frequency with which these fungi cause infections in humans.
Praveen R Juvvadi, William J Steinbach
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Calcineurin inhibitors and calcineurin-NFAT system
Japanese Journal of Clinical Immunology, 2010 Cyclosporin A and tacrolimus have been used as immunosuppressive agents initially in organ transplantation after their discovery, and are also used for treatment of the autoimmune disease, providing an excellent therapeutic effect. These agents act targeting on intracellular phosphatase calcineurin (CN), and subsequently inhibit activation of nuclear ...
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Selective Targeting of Calcineurin Isoforms by Calcineurin Inhibitors
The FASEB Journal, 2021 Background Calcineurin inhibitors (CNIs) have increased one‐year and five‐year post‐transplantation survival rates to ~90% and ~75%, respectively. While CNIs have dramatically improved the quality of patient care, their side effects are also noteworthy: long‐term CNI therapy is nephrotoxic and is a growing ...
Adaku Ume, Clintoria Williams
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Calcineurin inhibitorok hatása humán podocyták életképességére
, 2021 A podocyták rendkívül fontos szerepet töltenek be a filtrációs barrier fenntartásában és a fehérjék vizeletből való visszatartásában, mely feladatukat különleges morfológiájuk és sejtkapcsoló struktúráik segítségével látják el.
Racskó, Márk
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