Results 31 to 40 of about 78,892 (304)
Frontiers in Molecular Neuroscience, 2017 In the present study, we generated and characterized a splice site-specific monoclonal antibody that selectively detects the calcineurin-binding dynamin1 splice variant dynamin1xb.
Marie-Lisa Eich +5 more
doaj +1 more source
Pathogens, 2015 Studies on fungal pathogens belonging to the ascomycota phylum are critical given the ubiquity and frequency with which these fungi cause infections in humans.
Praveen R Juvvadi, William J Steinbach
doaj +1 more source
Selective Targeting of Calcineurin Isoforms by Calcineurin Inhibitors
The FASEB Journal, 2021 Background Calcineurin inhibitors (CNIs) have increased one‐year and five‐year post‐transplantation survival rates to ~90% and ~75%, respectively. While CNIs have dramatically improved the quality of patient care, their side effects are also noteworthy: long‐term CNI therapy is nephrotoxic and is a growing ...
Adaku Ume, Clintoria Williams
openaire +1 more source
Oral voclosporin: novel calcineurin inhibitor for treatment of noninfectious uveitis
, 2011 Martin Roesel1, Christoph Tappeiner2, Arnd Heiligenhaus1,3, Carsten Heinz1,31Department of Ophthalmology, St Franziskus-Hospital, Muenster, Germany; 2Department of Ophthalmology, Inselspital, University of Bern, Switzerland; 3University Duisburg-Essen ...
Heiligenhaus A +3 more
core +2 more sources
eLifeCalcineurin is a highly conserved calcium/calmodulin-dependent serine/threonine protein phosphatase with diverse functions. Inhibition of calcineurin is known to enhance the lifespan of Caenorhabditis elegans through multiple signaling pathways.
Priyanka Das +2 more
doaj +1 more source
Calcineurin in development and disease
Genes & Diseases, 2022 Calcineurin (CaN) is a unique calcium (Ca2+) and calmodulin (CaM)-dependent serine/threonine phosphatase that becomes activated in the presence of increased intracellular Ca2+ level. CaN then functions to dephosphorylate target substrates including various transcription factors, receptors, and channels.
Lei Chen, Min Song, Chunyan Yao
openaire +3 more sources
Calcineurin in cancer signaling networks [PDF]
Calcium/calcineurin/nuclear factor of activated T-cell signaling is a vital regulator of the development and function of immune, nervous, cardiovascular, and musculoskeletal systems.
Tsubota, Shomas +2 more
core +1 more source
Calcineurin inhibitors and calcineurin-NFAT system
Japanese Journal of Clinical Immunology, 2010 Cyclosporin A and tacrolimus have been used as immunosuppressive agents initially in organ transplantation after their discovery, and are also used for treatment of the autoimmune disease, providing an excellent therapeutic effect. These agents act targeting on intracellular phosphatase calcineurin (CN), and subsequently inhibit activation of nuclear ...
openaire +3 more sources
Calcineurin inhibitorok hatása humán podocyták életképességére
, 2021 A podocyták rendkívül fontos szerepet töltenek be a filtrációs barrier fenntartásában és a fehérjék vizeletből való visszatartásában, mely feladatukat különleges morfológiájuk és sejtkapcsoló struktúráik segítségével látják el.
Racskó, Márk
core
eLife, 2017 Postnatal development of skeletal muscle is a highly dynamic period of tissue remodeling. Here, we used RNA-seq to identify transcriptome changes from late embryonic to adult mouse muscle and demonstrate that alternative splicing developmental ...
Amy E Brinegar +5 more
doaj +1 more source