Results 41 to 50 of about 78,892 (304)

A novel αB-crystallin R123W variant drives hypertrophic cardiomyopathy by promoting maladaptive calcium-dependent signal transduction

Frontiers in Cardiovascular Medicine, 2023
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder affecting 1 in 500 people in the general population. Characterized by asymmetric left ventricular hypertrophy, cardiomyocyte disarray and cardiac fibrosis, HCM is a ...
Chun Chou, Gregory L. Martin, Gayani Perera, Junya Awata, Amy Larson, Robert Blanton, Robert Blanton, Michael T. Chin, Michael T. Chin   +8 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Mechanisms of calcineurin inhibitor nephrotoxicity in chronic allograft injury

, 2012
The first successful transplantation of a human kidney was performed more than 50 years ago by Murray and colleagues in 1954 between identical twins. The success of this transplantation was due to the fact that no significant rejection occurs between ...
Ryan, Michael P., Johnston, Olwyn, Hilary Cassidy, Michael P. Ryan, Slattery, Craig, Tara McMorrow, Cassidy, Hilary, Craig Slattery, Olwyn Johnston, Michael P., McMorrow, Tara   +10 more
core   +2 more sources

Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation [PDF]

, 2009
CsA (cyclosporin A) is a hydrophobic undecapeptide that inhibits CyPs (cyclophilins), a family of PPIases (peptidylprolyl cis–trans isomerases). In some experimental models, CsA offers partial protection against lethal cell injury brought about by ...
Crompton, M., Henry Dube, Malouitre, S., Sylvanie Malouitre, Selwood, D., Martin Crompton, Dube, H., David Selwood   +7 more
core   +1 more source

Glial Ca2+signaling links endocytosis to K+ buffering around neuronal somas to regulate excitability

eLife, 2019
Glial-neuronal signaling at synapses is widely studied, but how glia interact with neuronal somas to regulate their activity is unclear. Drosophila cortex glia are restricted to brain regions devoid of synapses, providing an opportunity to characterize ...
Shirley Weiss, Jan E Melom, Kiel G Ormerod, Yao V Zhang, J Troy Littleton   +4 more
doaj   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial Membrane Potential and Myocardial Reperfusion Injury

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
Background The transient receptor potential vanilloid 1 (TRPV1) mediates cellular responses to pain, heat, or noxious stimuli by calcium influx; however, the cellular localization and function of TRPV1 in the cardiomyocyte is largely unknown.
Carl M. Hurt, Yao Lu, Creed M. Stary, Honit Piplani, Bryce A. Small, Travis J. Urban, Nir Qvit, Garrett J. Gross, Daria Mochly‐Rosen, Eric R. Gross   +9 more
doaj   +1 more source

Single‐Incision Laparoscopy‐First Strategy in Crohn's Disease: Risk Factors for Conversion and Surgical Outcomes

Annals of Gastroenterological Surgery, EarlyView.
In this retrospective study of 289 patients with Crohn's disease undergoing a single‐incision laparoscopy‐first (SILS‐first) strategy, conversion to open surgery was required in only 11.8% of cases. Fistula formation, colon resection, and smoking history were identified as independent risk factors for conversion, while postoperative complications and ...
Yuki Horio, Motoi Uchino, Yusuke Tomoo, Kentaro Nagano, Kurando Kusunoki, Ryuichi Kuwahara, Kei Kimura, Kozo Kataoka, Masataka Ikeda, Hiroki Ikeuchi   +9 more
wiley   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Additional file 1: of TRPV2-induced Ca2+-calcineurin-NFAT signaling regulates differentiation of osteoclast in multiple myeloma

, 2018
Figure S1. Schematic model illustrating how TRPV2 regulates calcineurin/NFATc3 signaling pathway and osteoclastic differentiation in high [Ca2+]o conditions.
Juejin Wang (5863832), Lijuan Chen (150349), Xiupan Lu (5863829), Qing Yan (72879), Hua Bai (145775), Jianyong Li (133044), Huayuan Zhu (5863823), Xuxing Shen (5863826)   +7 more
core   +1 more source