Results 1 to 10 of about 32,558 (245)
HIV-1 Vpr induces an NFAT-controlled transcriptional program in primary CD4+ T cells [PDF]
mBioHIV-1 Vpr has a major impact on the cellular transcriptome and proteome. Although Vpr is known to stimulate the nuclear factor of activated T cells (NFAT), it remained unclear to what extent transcriptional changes induced by Vpr are governed by NFAT. We,
Johanna Leyens +7 more
doaj +2 more sources
Role of NFAT in the Progression of Diabetic Atherosclerosis [PDF]
Frontiers in Cardiovascular Medicine, 2021 Nuclear factor of activated T cells (NFAT) is a transcription factor with a multidirectional regulatory function, that is widely expressed in immune cells, including cells in the cardiovascular system, and non-immune cells. A large number of studies have
Yaoyao Cai +6 more
doaj +3 more sources
Revisiting the Concept of Targeting NFAT to Control T Cell Immunity and Autoimmune Diseases
Frontiers in Immunology, 2018 The nuclear factor of activated T cells (NFAT) family of transcription factors, which includes NFAT1, NFAT2, and NFAT4, are well-known to play important roles in T cell activation.
Jae-Ung Lee, Je-Min Choi
exaly +3 more sources
Endocrine and metabolic determinants of cardiometabolic risk in mild autonomous cortisol secretionResearch in context [PDF]
EBioMedicineSummary: Background: Benign adrenal tumours, found in 1–7% of adults, can be non-functioning (NFAT) or show mild autonomous cortisol secretion (MACS), i.e., biochemical cortisol excess without manifestations of Cushing's syndrome (CS). MACS occurs in 20–
Alessandro Prete +50 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Calcineurin (CN) controls the immune response by regulating nuclear factor of activated T cells (NFAT). Inhibition of CN function is an effective treatment for immune diseases.
Ping Wang +9 more
doaj +1 more source
The Journal of Cell Biology, 2002 The nuclear factor of activated T cells (NFAT) proteins are a family of transcription factors whose activation is controlled by calcineurin, a Ca2+-dependent phosphatase. Originally identified in T cells as inducers of cytokine gene expression, NFAT proteins play varied roles in cells outside of the immune system.
Valerie Horsley, Grace K. Pavlath
openaire +1 more source
NGF activates NFAT via the MEK1/2 pathway in PC12 cells
All Life, 2022 Nerve growth factor (NGF) plays a key role in controlling growth, maintenance and survival of neurons as well as nociceptor development. Many of its critical actions are believed to be mediated by activation of corresponding transcription factors. Here I
Man Su Kim
doaj +1 more source
Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection [PDF]
Open Biology, 2016 The majority of T cells encountered by HIV-1 are non-activated and do not readily allow productive infection. HIV-1 Vpr is highly abundant in progeny virions, and induces signalling and HIV-1 LTR transcription.
Kristin Höhne +9 more
doaj +1 more source
Molecular Metabolism, 2022 Objective: Diabetes occurs because of insufficient insulin secretion due to β-cell dysfunction within the islet of Langerhans. Elevated glucose levels trigger β-cell membrane depolarization, action potential generation, and slow sustained free-Ca2+ ([Ca2+
Jose G. Miranda +5 more
doaj +1 more source
The involvement of NFAT transcriptional activity suppression in SIRT1-mediated inhibition of COX-2 expression induced by PMA/Ionomycin. [PDF]
PLoS ONE, 2014 SIRT1, a class III histone deacetylase, acts as a negative regulator for many transcription factors, and plays protective roles in inflammation and atherosclerosis. Transcription factor nuclear factor of activated T cells (NFAT) has been previously shown
Yu-Yan Jia +13 more
doaj +1 more source