Results 1 to 10 of about 35,937 (157)
NFAT signaling dysregulation in cancer: Emerging roles in cancer stem cells
Biomedicine and Pharmacotherapy, 2023 The nuclear factor of activated T cells (NFAT) was first identified as a transcriptional regulator of activated T cells. The NFAT family is involved in the development of tumors.
Sheng Han, Lin Yibin
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Molecular Metabolism, 2022 Objective: Diabetes occurs because of insufficient insulin secretion due to β-cell dysfunction within the islet of Langerhans. Elevated glucose levels trigger β-cell membrane depolarization, action potential generation, and slow sustained free-Ca2+ ([Ca2+
Jose G. Miranda +5 more
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Targeting CaN/NFAT in Alzheimer’s brain degeneration
Frontiers in Immunology, 2023 Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a progressive loss of cognitive functions. While the exact causes of this debilitating disorder remain elusive, numerous investigations have characterized its two core pathologies:
Joanna Mackiewicz +2 more
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Role of NFAT in the Progression of Diabetic Atherosclerosis
Frontiers in Cardiovascular Medicine, 2021 Nuclear factor of activated T cells (NFAT) is a transcription factor with a multidirectional regulatory function, that is widely expressed in immune cells, including cells in the cardiovascular system, and non-immune cells. A large number of studies have
Yaoyao Cai +6 more
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Revisiting the Concept of Targeting NFAT to Control T Cell Immunity and Autoimmune Diseases
Frontiers in Immunology, 2018 The nuclear factor of activated T cells (NFAT) family of transcription factors, which includes NFAT1, NFAT2, and NFAT4, are well-known to play important roles in T cell activation.
Jae-Ung Lee +5 more
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Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy [PDF]
Animal Models and Experimental MedicineThe Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors. Numerous biological processes including angiogenesis, invasion, migration, proliferation, and cell survival are regulated by the NFAT family. NFATs are
Hira Khan +6 more
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Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance NFAT:AP-1 cooperation is pivotal for the productive immune response, but when this response is exacerbated, it is implicated in autoimmune and inflammatory diseases.
Roberto Spreafico +2 more
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Calcium–NFAT transcriptional signalling in T cell activation and T cell exhaustion
Cell Calcium, 2017 A cornerstone of the adaptive immune response is the T cell receptor (TcR)–calcium–calcineurin signalling pathway leading to T cell activation. The ‘nuclear factor of activated T cells’ proteins NFAT1, NFAT2, and NFAT4 are transcription factors that ...
Patrick Hogan
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Calcineurin/NFAT signaling in the temporal integration of Ca²⁺ stress in neurodegeneration [PDF]
Cell Death DiscoveryThe calcineurin (CaN)/nuclear factor of activated T cells (NFAT) signalling axis is a Ca²⁺-responsive pathway that translates intracellular Ca²⁺ signals into long-term transcriptional programmes. Chronic disruption of intracellular Ca²⁺ homoeostasis is a
Bruna Da Silva Oliveira +2 more
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F1000Research, 2018 Nuclear factor of activated T cells (NFAT) was first described almost three decades ago as a Ca2+/calcineurin-regulated transcription factor in T cells. Since then, a large body of research uncovered the regulation and physiological function of different
Martin Vaeth, Stefan Feske
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