Results 31 to 40 of about 32,558 (245)
The International Journal of Biological Markers, 2007 Purpose Nuclear factor of activated T cells (NFAT) has been reported to be involved in the development of various types of cancer including adenocarcinoma of the breast.
K. Zhang +15 more
doaj +1 more source
NFATc1 regulation of TRAIL expression in human intestinal cells. [PDF]
PLoS ONE, 2011 TNF-related apoptosis-inducing ligand (TRAIL; Apo2) has been shown to promote intestinal cell differentiation. Nuclear factor of activated T cells (NFAT) participates in the regulation of a variety of cellular processes, including differentiation.
Qingding Wang +4 more
doaj +1 more source
Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT.
, 2005 International audienceThe phosphoinositide 3-kinase (PI 3-K) signaling axis is intimately associated with deregulated cancer cell growth, primarily by promoting increased survival through Akt/PKB (protein kinase B).
Yoeli-Lerner, Merav +5 more
core +1 more source
PLoS ONE, 2021 T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy with few available targeted therapies. We previously reported that the phosphatase calcineurin (Cn) is required for LIC (leukemia Initiating Capacity) potential of T-ALL pointing to ...
Claire Catherinet +7 more
doaj +1 more source
Testosterone activates NFAT in cardiac myocytes.
, 2016 NFAT activity was determined in cardiac myocytes transfected with a NFAT luciferase-reporter plasmid (NFAT-Luc) and normalized relative to Renilla luciferase activity in each sample.
Daniel Lagos (3559814) +9 more
core +1 more source
SH3BP2 is an activator of NFAT activity and osteoclastogenesis [PDF]
Biochemical and Biophysical Research Communications, 2008 Heterozygous activating mutations in exon 9 of SH3BP2 have been found in most patients with cherubism, an unusual genetic syndrome characterized by excessive remodeling of the mandible and maxilla due to spontaneous and excessive osteoclastic bone resorption.
Steven A, Lietman +2 more
openaire +2 more sources
SIRT1 suppresses NFAT transcriptional activity.
, 2014 (A) HEK293 cells were transfected with 0.1 µg NFAT luciferase reporter (NFAT-luc), 30 ng pRL-TK, and 0.3 µg SIRT1 expression vector or control (pcDNA3.1) for 24 h and treated with PMA (10 ng/ml) and Io (0.25 µM) or vehicle for another 3 h.
Yan-Zhen Wan (568221) +13 more
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice. [PDF]
PLoS ONE, 2014 OBJECTIVE OF THE STUDY: Diabetic patients have a much more widespread and aggressive form of atherosclerosis and therefore, higher risk for myocardial infarction, peripheral vascular disease and stroke, but the molecular mechanisms leading to accelerated
Anna V Zetterqvist +11 more
doaj +1 more source
Mathematics of the NFAT Signaling Pathway
SIAM Journal on Applied Dynamical Systems, 2012 This paper is a mathematical study of some aspects of the signalling pathway leading to the activation of the transcription factor NFAT (nuclear factor of activated T cells). Activation takes place by dephosphorylation at multiple sites. This has been modelled by Salazar and Höfer using a large system of ordinary differential equations depending on ...
openaire +4 more sources