Results 31 to 40 of about 41,205 (276)
Nuclear factor of activated T-cells (NFAT) regulation of IL-1β-induced retinal vascular inflammation
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2021 Chronic low-grade retinal inflammation is an essential contributor to the pathogenesis of diabetic retinopathy (DR). It is characterized by increased retinal cell expression and secretion of a variety of inflammatory cytokines; among these, IL-1β has the
Meredith J Giblin +8 more
semanticscholar +1 more source
The Journal of Cell Biology, 2002 The nuclear factor of activated T cells (NFAT) proteins are a family of transcription factors whose activation is controlled by calcineurin, a Ca2+-dependent phosphatase. Originally identified in T cells as inducers of cytokine gene expression, NFAT proteins play varied roles in cells outside of the immune system.
Horsley, Valerie, Pavlath, Grace K.
openaire +2 more sources
The involvement of NFAT transcriptional activity suppression in SIRT1-mediated inhibition of COX-2 expression induced by PMA/Ionomycin. [PDF]
PLoS ONE, 2014 SIRT1, a class III histone deacetylase, acts as a negative regulator for many transcription factors, and plays protective roles in inflammation and atherosclerosis. Transcription factor nuclear factor of activated T cells (NFAT) has been previously shown
Yu-Yan Jia +13 more
doaj +1 more source
eLife, 2020 Mechanical forces are fundamental regulators of cell behaviors. However, molecular regulation of mechanotransduction remain poorly understood. Here, we identified the mechanosensitive channels Piezo1 and Piezo2 as key force sensors required for bone ...
Tai-Feng Zhou +15 more
semanticscholar +1 more source
The Role of Calcium–Calcineurin–NFAT Signaling Pathway in Health and Autoimmune Diseases
Frontiers in Immunology, 2020 Calcium (Ca2+) is an essential signaling molecule that controls a wide range of biological functions. In the immune system, calcium signals play a central role in a variety of cellular functions such as proliferation, differentiation, apoptosis, and ...
Yune-Jung Park +3 more
semanticscholar +1 more source
Journal of Clinical Investigation, 2021 Inhibitors of calcineurin phosphatase activity (CNIs) such as cyclosporin A (CsA) are widely used to treat tissue transplant rejection and acute graft-versus-host disease (aGVHD), for which inhibition of NFAT-dependent gene expression is the mechanistic ...
S. Otsuka +5 more
semanticscholar +1 more source
Lysine Acetylation Reshapes the Downstream Signaling Landscape of Vav1 in Lymphocytes
Cells, 2020 Vav1 works both as a catalytic Rho GTPase activator and an adaptor molecule. These functions, which are critical for T cell development and antigenic responses, are tyrosine phosphorylation-dependent.
Sonia Rodríguez-Fdez +3 more
doaj +1 more source
Herpesviral G protein-coupled receptors activate NFAT to induce tumor formation via inhibiting the SERCA calcium ATPase. [PDF]
PLoS Pathogens, 2015 G protein-coupled receptors (GPCRs) constitute the largest family of proteins that transmit signal to regulate an array of fundamental biological processes.
Junjie Zhang +6 more
doaj +1 more source
Immunity, 2021 SUMMARY During gram-negative septicemia, interactions between platelets and neutrophils initiate a detrimental feedback loop that sustains neutrophil extracellular trap (NET) induction, disseminated intravascular coagulation, and inflammation ...
Valentina Poli +6 more
semanticscholar +1 more source
A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis. [PDF]
PLoS ONE, 2012 Nuclear factor of activated T cells (NFAT) plays a critical role in the development and function of immune and non-immune cells. Although NFAT is a central transcriptional regulator of T cell cytokines, its role in macrophage specific gene expression is ...
Houda Z Elloumi +8 more
doaj +1 more source