Results 11 to 20 of about 41,205 (276)
NFAT control of innate immunity [PDF]
Blood, 2012 AbstractThe calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway mediates multiple adaptive T-cell functions, but recent studies have shown that calcineurin/NFAT signaling also contributes to innate immunity and regulates the homeostasis of innate cells.
Fric, Jan +5 more
openaire +4 more sources
NFAT Regulation in Smooth Muscle
Trends in Cardiovascular Medicine, 2003 First identified in activated T cells, the calcium (Ca2+)-dependent transcription factor, nuclear factor of activated T cells (NFAT), has since been shown to play a role in nonimmune cells, including cells of the cardiovascular system. In arterial smooth muscle, the diverse array of calcium-signaling modalities, the functional interplay between smooth ...
Nelson, Mark; id_orcid 0000-0002-6608-8784 +4 more
core +5 more sources
Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia [PDF]
Hemato, 2021 Acute myeloid leukaemia (AML) is a haematological cancer with poor outcomes due to a lack of efficacious targeted therapies. The Nuclear Factor of Activated T Cells (NFAT) family of transcription factors is well characterised as a regulator of the cell ...
Shaun D. Patterson +3 more
doaj +2 more sources
Isoform-Selective NFAT Inhibitor: Potential Usefulness and Development
International Journal of Molecular Sciences, 2021 Nuclear factor of activated T cells (NFAT), which is the pharmacological target of immunosuppressants cyclosporine and tacrolimus, has been shown to play an important role not only in T cells (immune system), from which their name is derived, but also in
N. Kitamura, O. Kaminuma
semanticscholar +2 more sources
Transcriptional Regulation of TMP21 by NFAT [PDF]
Molecular Neurodegeneration, 2011 Background: TMP21 is a member of the p24 cargo protein family, which is involved in protein transport between the Golgi apparatus and ER. Alzheimer's Disease (AD) is the most common neurodegenerative disorder leading to dementia and deposition of amyloid β protein (Aβ) is the pathological feature of AD pathogenesis.
Liu, Shengchun +7 more
core +7 more sources
Micro-RNA Feedback Loops Modulating the Calcineurin/NFAT Signaling Pathway [PDF]
Non-Coding RNA, 2016 Nuclear factor of activated T cells (NFAT) is a family of transcription factors important for innate and adaptive immune responses. NFAT activation is tightly regulated through the calcineurin/NFAT signaling pathway.
Shichina Kannambath
doaj +2 more sources
FOXP3 controls regulatory T cell function through cooperation with NFAT. [PDF]
Cell, 2006 Antigen stimulation of immune cells activates the transcription factor NFAT, a key regulator of T cell activation and anergy. NFAT forms cooperative complexes with the AP-1 family of transcription factors and regulates T cell activation-associated genes.
Yongqing Wu +13 more
semanticscholar +2 more sources
GSK-3β/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy. [PDF]
PLoS ONE, 2016 Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted crosstalk between cytosolic and nuclear signaling pathways.
Javier Duran +9 more
doaj +3 more sources
Cell Reports, 2019 Summary: Long-term information storage in the brain requires continual modification of the neuronal transcriptome. Synaptic inputs located hundreds of micrometers from the nucleus can regulate gene transcription, requiring high-fidelity, long-range ...
Angela R. Wild +5 more
doaj +2 more sources
Science Signaling, 2011 Loss of the kinase LRRK2 promotes the activity of the transcription factor NFAT, leading to enhanced inflammatory bowel disease.
John F. Foley
openaire +2 more sources