NFAT control of innate immunity [PDF]
Blood, 2012 AbstractThe calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway mediates multiple adaptive T-cell functions, but recent studies have shown that calcineurin/NFAT signaling also contributes to innate immunity and regulates the homeostasis of innate cells.
Fric, Jan +5 more
openaire +4 more sources
Transcriptional Regulation of TMP21 by NFAT [PDF]
Molecular Neurodegeneration, 2011 Background: TMP21 is a member of the p24 cargo protein family, which is involved in protein transport between the Golgi apparatus and ER. Alzheimer's Disease (AD) is the most common neurodegenerative disorder leading to dementia and deposition of amyloid β protein (Aβ) is the pathological feature of AD pathogenesis.
Liu, Shengchun +7 more
core +7 more sources
Transcriptional Regulation by the NFAT Family in Acute Myeloid Leukaemia [PDF]
Hemato, 2021 Acute myeloid leukaemia (AML) is a haematological cancer with poor outcomes due to a lack of efficacious targeted therapies. The Nuclear Factor of Activated T Cells (NFAT) family of transcription factors is well characterised as a regulator of the cell ...
Shaun D. Patterson +3 more
doaj +2 more sources
Micro-RNA Feedback Loops Modulating the Calcineurin/NFAT Signaling Pathway
Non-Coding RNA, 2016 Nuclear factor of activated T cells (NFAT) is a family of transcription factors important for innate and adaptive immune responses. NFAT activation is tightly regulated through the calcineurin/NFAT signaling pathway.
Shichina Kannambath
doaj +2 more sources
GSK-3β/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy. [PDF]
PLoS ONE, 2016 Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted crosstalk between cytosolic and nuclear signaling pathways.
Javier Duran +9 more
doaj +3 more sources
Duvelisib is a novel NFAT inhibitor that mitigates adalimumab-induced immunogenicity [PDF]
Frontiers in PharmacologyIntroductionTNFα inhibitor (TNFi) immunogenicity in rheumatoid arthritis (RA) is a major obstacle to its therapeutic effectiveness. Although methotrexate (MTX) can mitigate TNFi immunogenicity, its adverse effects necessitate alternative strategies ...
Aboli Bhingarkar +12 more
doaj +2 more sources
Lysine Acetylation Reshapes the Downstream Signaling Landscape of Vav1 in Lymphocytes
Cells, 2020 Vav1 works both as a catalytic Rho GTPase activator and an adaptor molecule. These functions, which are critical for T cell development and antigenic responses, are tyrosine phosphorylation-dependent.
Sonia Rodríguez-Fdez +3 more
doaj +1 more source
Herpesviral G protein-coupled receptors activate NFAT to induce tumor formation via inhibiting the SERCA calcium ATPase. [PDF]
PLoS Pathogens, 2015 G protein-coupled receptors (GPCRs) constitute the largest family of proteins that transmit signal to regulate an array of fundamental biological processes.
Junjie Zhang +6 more
doaj +1 more source
Role of NFAT in Chronic Lymphocytic Leukemia and Other B-Cell Malignancies
Frontiers in Oncology, 2021 In recent years significant progress has been made in the clinical management of chronic lymphocytic leukemia (CLL) as well as other B-cell malignancies; targeting proximal B-cell receptor signaling molecules such as Bruton Tyrosine Kinase (BTK) and ...
Ilenia Sana +4 more
doaj +1 more source
A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis. [PDF]
PLoS ONE, 2012 Nuclear factor of activated T cells (NFAT) plays a critical role in the development and function of immune and non-immune cells. Although NFAT is a central transcriptional regulator of T cell cytokines, its role in macrophage specific gene expression is ...
Houda Z Elloumi +8 more
doaj +1 more source