Results 21 to 30 of about 32,558 (245)
FOXP3 and NFAT: Partners in Tolerance [PDF]
Cell, 2006 Regulatory T cells suppress autoimmune responses to self-antigens. Recent studies, including one in this issue of Cell (Wu et al., 2006), suggest that the ability of T cells to choose between launching a productive immune response, functional inactivation, or developing into regulatory T cells depends upon the interplay of the key transcriptional ...
Rudensky, Alexander Y. +2 more
openaire +2 more sources
NFAT1 C-terminal domains are necessary but not sufficient for inducing cell death. [PDF]
PLoS ONE, 2012 The proteins belonging to the nuclear factor of activated T cells (NFAT) family of transcription factors are expressed in several cell types and regulate genes involved in differentiation, cell cycle and apoptosis.
Douglas V Faget +3 more
doaj +1 more source
Delivery of the VIVIT Peptide to Human Glioma Cells to Interfere with Calcineurin-NFAT Signaling
Molecules, 2021 The activation of NFAT (nuclear factor of activated T cells) transcription factors by calcium-dependent phosphatase calcineurin is a key step in controlling T cell activation and plays a vital role during carcinogenesis.
Aleksandra Ellert-Miklaszewska +3 more
doaj +1 more source
Selective Inhibition of NFAT Activation by a Peptide Spanning the Calcineurin Targeting Site of NFAT [PDF]
Molecular Cell, 1998 NFAT transcription factors play a key role in the immune response. The activation of NFAT proteins is controlled by calcineurin, the calmodulin-dependent phosphatase that is inhibited by the immunosuppressive drugs cyclosporin A and FK506. Here we identify a short conserved sequence in NFAT proteins that targets calcineurin to NFAT.
Aramburu, José +5 more
openaire +2 more sources
Do microRNAs play a role in the activity of plant-based vaccines?
Expert Review of Vaccines, 2017 Introduction: An important trend in vaccinology is the development of oral vaccines based on genetically modified plants. Areas covered: Several studies have suggested that dietary microRNAs from plants and other organisms are bioavailable upon oral ...
Sergio Rosales-Mendoza +1 more
doaj +1 more source
Safety and efficacy of Tet-regulated IL-12 expression in cancer-specific T cells
OncoImmunology, 2019 We explored whether engineering of T cell specificity and effector function improves immunotherapy of solid tumors. Although IL-12 can enhance cancer immunity, a strategy of safe IL-12 delivery without toxicity is currently lacking. We engineered T cells
Ahdab Alsaieedi +4 more
doaj +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Calcineurin inhibitors: status quo and perspectives
Biomolecular Concepts, 2011 Despite the fact that cyclosporin A (CsA) and tacrolimus (FK506) are very potent drugs in the treatment of serious autoimmune diseases and in the prevention of graft vs.
Erdmann Frank, Weiwad Matthias
doaj +1 more source
Isoform-Selective NFAT Inhibitor: Potential Usefulness and Development
, 2021 Nuclear factor of activated T cells (NFAT), which is the pharmacological target of immunosuppressants cyclosporine and tacrolimus, has been shown to play an important role not only in T cells (immune system), from which their name is derived, but also in
Osamu Kaminuma, Noriko Kitamura
core +1 more source
Targeting CaN/NFAT in Alzheimer’s brain degeneration
Frontiers in Immunology, 2023 Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a progressive loss of cognitive functions. While the exact causes of this debilitating disorder remain elusive, numerous investigations have characterized its two core pathologies:
Joanna Mackiewicz +2 more
doaj +1 more source