Results 21 to 30 of about 41,205 (276)

Transcriptional regulation by calcium, calcineurin, and NFAT. [PDF]

Genes & Development, 2003
The NFAT family of transcription factors encompasses five proteins evolutionarily related to the Rel/NF B family (Chytil and Verdine 1996; Graef et al. 2001b).
P. Hogan, Lin Chen, Julie Nardone, A. Rao   +3 more
semanticscholar   +3 more sources

Enhancement of a nuclear factor of activated T cells (NFAT) reporter for the study of G protein-coupled receptors [PDF]

Communications Biology
Cell-based assays are fundamental to G protein-coupled receptor (GPCRs) drug discovery. As the field strives to increase the use of physiological cell types with endogenous receptor expression, enhancing the sensitivity of simple-to-use assays unlocks ...
Edward Wills, Anjana Saji, Jonathan Sumner, Aman Khan, Claudia M. Sisk, Mona Shehata, Benjamin Taylor, Graham Ladds   +7 more
doaj   +2 more sources

HIV-1 Vpr induces an NFAT-controlled transcriptional program in primary CD4+ T cells [PDF]

mBio
HIV-1 Vpr has a major impact on the cellular transcriptome and proteome. Although Vpr is known to stimulate the nuclear factor of activated T cells (NFAT), it remained unclear to what extent transcriptional changes induced by Vpr are governed by NFAT. We,
Johanna Leyens, Carlos Alberto Vanegas-Torres, Anthea Darius, Rabea Seizer, Brigitta Maurer, Daniel Sauter, Rishikesh Lotke, Michael Schindler   +7 more
doaj   +2 more sources

NFAT signaling: choreographing the social lives of cells. [PDF]

Cell, 2002
G. Crabtree, E. Olson
semanticscholar   +2 more sources

A polypeptide inhibitor of calcineurin blocks the calcineurin-NFAT signalling pathway in vivo and in vitro

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Calcineurin (CN) controls the immune response by regulating nuclear factor of activated T cells (NFAT). Inhibition of CN function is an effective treatment for immune diseases.
Ping Wang, Wenying Li, Yumeng Yang, Na Cheng, Yuchen Zhang, Nan Zhang, Yanxia Yin, Li Tong, Zhimei Li, Jing Luo   +9 more
doaj   +1 more source

NFAT and NF-κB dynamically co-regulate TCR and CAR signaling responses in human T cells.

Cell Reports, 2023
While it has been established that the responses of T cells to antigens are combinatorially regulated by multiple signaling pathways, it remains elusive what mechanisms cells utilize to quantitatively modulate T cell responses during pathway integration.
Wen Huang, Wei Lin, Baoqiang Chen, Jianhan Zhang, Peifen Gao, Yingying Fan, Yihan Lin, Ping Wei   +7 more
semanticscholar   +1 more source

NGF activates NFAT via the MEK1/2 pathway in PC12 cells

All Life, 2022
Nerve growth factor (NGF) plays a key role in controlling growth, maintenance and survival of neurons as well as nociceptor development. Many of its critical actions are believed to be mediated by activation of corresponding transcription factors. Here I
Man Su Kim
doaj   +1 more source

The role of Ca2+/Calcineurin/NFAT signalling pathway in osteoblastogenesis

Cell Proliferation, 2021
The bone remodelling process is closely related to bone health. Osteoblasts and osteoclasts participate in the bone remodelling process under the regulation of various factors inside and outside. Excessive activation of osteoclasts or lack of function of
Ran-Yue Ren, Jia-Chao Guo, Yangmengfan Chen, Ya-Yun Zhang, Liang Chen, W. Xiong   +5 more
semanticscholar   +1 more source

Cooperative Binding of ETS2 and NFAT Links Erk1/2 and Calcineurin Signaling in the Pathogenesis of Cardiac Hypertrophy

Circulation, 2021
Supplemental Digital Content is available in the text. Background: Cardiac hypertrophy is an independent risk factor for heart failure, a leading cause of morbidity and mortality globally.
Yuxuan Luo, Nan Jiang, Herman I. May, Xiang Luo, A. Ferdous, G. Schiattarella, Guihao Chen, Qin-Feng Li, Chao Li, B. Rothermel, D. Jiang, S. Lavandero, T. Gillette, Joseph A. Hill   +13 more
semanticscholar   +1 more source

Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection [PDF]

Open Biology, 2016
The majority of T cells encountered by HIV-1 are non-activated and do not readily allow productive infection. HIV-1 Vpr is highly abundant in progeny virions, and induces signalling and HIV-1 LTR transcription.
Kristin Höhne, Ramona Businger, Anouk van Nuffel, Sebastian Bolduan, Herwig Koppensteiner, Ann Baeyens, Jolien Vermeire, Eva Malatinkova, Bruno Verhasselt, Michael Schindler   +9 more
doaj   +1 more source