NFAT1 C-terminal domains are necessary but not sufficient for inducing cell death. [PDF]
PLoS ONE, 2012 The proteins belonging to the nuclear factor of activated T cells (NFAT) family of transcription factors are expressed in several cell types and regulate genes involved in differentiation, cell cycle and apoptosis.
Douglas V Faget +3 more
doaj +1 more source
Role of NFAT in Chronic Lymphocytic Leukemia and Other B-Cell Malignancies
Frontiers in Oncology, 2021 In recent years significant progress has been made in the clinical management of chronic lymphocytic leukemia (CLL) as well as other B-cell malignancies; targeting proximal B-cell receptor signaling molecules such as Bruton Tyrosine Kinase (BTK) and ...
Ilenia Sana +4 more
doaj +1 more source
Delivery of the VIVIT Peptide to Human Glioma Cells to Interfere with Calcineurin-NFAT Signaling
Molecules, 2021 The activation of NFAT (nuclear factor of activated T cells) transcription factors by calcium-dependent phosphatase calcineurin is a key step in controlling T cell activation and plays a vital role during carcinogenesis.
Aleksandra Ellert-Miklaszewska +3 more
doaj +1 more source
T-Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease. [PDF]
Adv Sci (Weinh)This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Li Q +11 more
europepmc +2 more sources
Safety and efficacy of Tet-regulated IL-12 expression in cancer-specific T cells
OncoImmunology, 2019 We explored whether engineering of T cell specificity and effector function improves immunotherapy of solid tumors. Although IL-12 can enhance cancer immunity, a strategy of safe IL-12 delivery without toxicity is currently lacking. We engineered T cells
Ahdab Alsaieedi +4 more
doaj +1 more source
Calcineurin inhibitors: status quo and perspectives
Biomolecular Concepts, 2011 Despite the fact that cyclosporin A (CsA) and tacrolimus (FK506) are very potent drugs in the treatment of serious autoimmune diseases and in the prevention of graft vs.
Erdmann Frank, Weiwad Matthias
doaj +1 more source
FOXP3 and NFAT: Partners in Tolerance [PDF]
Cell, 2006 Regulatory T cells suppress autoimmune responses to self-antigens. Recent studies, including one in this issue of Cell (Wu et al., 2006), suggest that the ability of T cells to choose between launching a productive immune response, functional inactivation, or developing into regulatory T cells depends upon the interplay of the key transcriptional ...
Rudensky, Alexander Y. +2 more
openaire +2 more sources
Sonogenetics Nanomedicine Activates the cGAS-STING Pathway for Immunotherapy of Triple-Negative Breast Cancer. [PDF]
Adv Sci (Weinh)A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Song J +6 more
europepmc +2 more sources
Selective Inhibition of NFAT Activation by a Peptide Spanning the Calcineurin Targeting Site of NFAT [PDF]
Molecular Cell, 1998 NFAT transcription factors play a key role in the immune response. The activation of NFAT proteins is controlled by calcineurin, the calmodulin-dependent phosphatase that is inhibited by the immunosuppressive drugs cyclosporin A and FK506. Here we identify a short conserved sequence in NFAT proteins that targets calcineurin to NFAT.
Aramburu, José +5 more
openaire +2 more sources
Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis
bioRxiv, 2020 The inflammatory response plays an important role in cholestatic liver injury where bile acid (BA) induction of proinflammatory cytokines in hepatocytes is an initial pathophysiologic event.
Shi-Ying Cai +4 more
semanticscholar +1 more source