Results 41 to 50 of about 32,558 (245)

Partners in transcription: NFAT and AP-1 [PDF]

Oncogene, 2001
Combinatorial regulation is a powerful mechanism that enables tight control of gene expression, via integration of multiple signaling pathways that induce different transcription factors required for enhanceosome assembly. The four calcium-regulated transcription factors of the NFAT family act synergistically with AP-1 (Fos/Jun) proteins on composite ...
F, Macián, C, López-Rodríguez, A, Rao
openaire   +2 more sources

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

NFAT Gene Expression.

, 2016
NFAT Gene Expression.
Latoya E. Campbell (2939922), Lawrence J. Mandarino (201367), Dawn K. Coletta (251343), Bruce Kaplan (2939919), Jean Finlayson (2939916), Jennifer Weil (2939913), Marie Clarkson (2939910), Harini A. Chakkera (823892)   +7 more
core   +1 more source

Extracellular ATP activates NFAT-dependent gene expression in neuronal PC12 cells via P2X receptors

BMC Neuroscience, 2011
Background Treatment of neuronal PC12 cells with ATP induces depolarisation and increases intracellular calcium levels via purinergic receptors. In many cell types, sustained elevation of intracellular calcium levels cause changes in gene expression via ...
Becker Walter, Stefos Georgios C, Prasai Prabin   +2 more
doaj   +1 more source

Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway. [PDF]

PLoS ONE, 2011
Sustained pressure overload leads to compensatory myocardial hypertrophy and subsequent heart failure, a leading cause of morbidity and mortality.
Alexandra V Finsen, Ida G Lunde, Ivar Sjaastad, Even K Østli, Marianne Lyngra, Hilde O Jarstadmarken, Almira Hasic, Ståle Nygård, Sarah A Wilcox-Adelman, Paul F Goetinck, Torstein Lyberg, Biljana Skrbic, Geir Florholmen, Theis Tønnessen, William E Louch, Srdjan Djurovic, Cathrine R Carlson, Geir Christensen   +17 more
doaj   +1 more source

Cardiovascular risk factors in mild adrenal autonomous cortisol secretion in a Caucasian population

Endocrine Connections, 2022
Cardiovascular risk factors could be present in mild adrenal au tonomous cortisol secretion (MACS). However, the most frequent cardiovascular risk factors in MACS have not been established.
Agnieszka Adamska, Vitalii Ulychnyi, Katarzyna Siewko, Anna Popławska-Kita, Małgorzata Szelachowska, Marcin Adamski, Angelika Buczyńska, Adam Jacek Krętowski   +7 more
doaj   +1 more source

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

Advanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu, Yaru Sun, Qi Lu, Yi Zhang, Jieruo Li, Huige Hou, Huajun Wang, Hui Tang, Yunsong Zhang, Xiaofei Zheng, Qingsong Mei   +10 more
wiley   +1 more source

The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis

Molecular Medicine, 2023
Background Soluble oligomeric forms of alpha-synuclein (aSyn-O) are believed to be one of the main toxic species in Parkinson’s disease (PD) leading to degeneration.
Ricardo Sant’Anna, Bruno K. Robbs, Júlia Araújo de Freitas, Patrícia Pires dos Santos, Annekatrin König, Tiago Fleming Outeiro, Debora Foguel   +6 more
doaj   +1 more source

NFAT in Pancreatic Carcinogenesis [PDF]

Journal of Carcinogenesis & Mutagenesis, 2014
Pancreatic Ductal Adenocarcinoma (PDAC) belongs to the most aggressive malignancies among solid tumors. The increasing incidence of PDAC and its dismal prognosis with a five-years overall survival rate of less than five percent characterize PDAC as one of the most clinically challenging diseases among all malignancies.
openaire   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source