Results 51 to 60 of about 41,205 (276)
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
The International Journal of Biological Markers, 2007 Purpose Nuclear factor of activated T cells (NFAT) has been reported to be involved in the development of various types of cancer including adenocarcinoma of the breast.
K. Zhang +15 more
doaj +1 more source
Targeting the Calcineurin-NFAT Interaction by Solution NMR Spectroscopy
, 2015 The serine/threonine phosphatase calcineurin (Cn) targets the nuclear factors of activated T cells (NFATs) that activate cytokine genes. Calcium influx activates Cn to dephosphorylate multiple serine residues within the ~200 residue NFAT regulatory ...
Li, Shuai
core +6 more sources
NFATc1 regulation of TRAIL expression in human intestinal cells. [PDF]
PLoS ONE, 2011 TNF-related apoptosis-inducing ligand (TRAIL; Apo2) has been shown to promote intestinal cell differentiation. Nuclear factor of activated T cells (NFAT) participates in the regulation of a variety of cellular processes, including differentiation.
Qingding Wang +4 more
doaj +1 more source
A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
Nature Communications, 2019 ORAI1 constitutes the store-operated Ca2+ release-activated Ca2+ (CRAC) channel crucial for life. Whereas ORAI1 activation by Ca2+-sensing STIM proteins is known, still obscure is how ORAI1 is turned off through Ca2+-dependent inactivation (CDI ...
Xue-Xin Zhang +13 more
semanticscholar +1 more source
Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT.
, 2005 International audienceThe phosphoinositide 3-kinase (PI 3-K) signaling axis is intimately associated with deregulated cancer cell growth, primarily by promoting increased survival through Akt/PKB (protein kinase B).
Yoeli-Lerner, Merav +5 more
core +1 more source
PLoS ONE, 2021 T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy with few available targeted therapies. We previously reported that the phosphatase calcineurin (Cn) is required for LIC (leukemia Initiating Capacity) potential of T-ALL pointing to ...
Claire Catherinet +7 more
doaj +1 more source
The transcription factor NFAT promotes exhaustion of activated CD8+ T cells
Immunity, 2015 SUMMARY During persistent antigen stimulation, CD8+ T cells show a gradual decrease in effector function, referred to as exhaustion, which impairs responses in the setting of tumors and infections.
G. Martinez +15 more
semanticscholar +1 more source
Testosterone activates NFAT in cardiac myocytes.
, 2016 NFAT activity was determined in cardiac myocytes transfected with a NFAT luciferase-reporter plasmid (NFAT-Luc) and normalized relative to Renilla luciferase activity in each sample.
Daniel Lagos (3559814) +9 more
core +1 more source
Scientific Reports, 2020 Ca2+/nuclear factor of activated T-cells (Ca2+/NFAT) signaling pathway may play a crucial role in the pathogenesis of Kawasaki disease (KD). We investigated the poorly understood Ca2+/NFAT regulation of coronary artery endothelial cells and consequent ...
Ying Wang +11 more
semanticscholar +1 more source